Increased familiarity of intellectual deficits in early-onset schizophrenia spectrum disorders

Goldberg, Ximena; Fatjó‐Vilas, Mar; Mj, Muñoz; Campanera, S.; Miret, Salvador; Mj, Miñano; Aguilera, Mari; Ml, Miralles; Me, Navarro; Lázaro, Luisa; Guitart, Marc; Barrantes‐Vidal, Neus; Fañanás, Lourdes

doi:10.3109/15622975.2011.585661

Cited by 8 publications

(6 citation statements)

References 46 publications

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“…Deficits in general intellectual ability (as measured with the intellectual quotient or IQ) and in the executive component of working memory have consistently been revealed in patients with schizophrenia [Gur et al, 2007; Toulopoulou et al, 2010] and are detectable even years before the onset of symptoms [Cannon et al, 2002; Barnett et al, 2012]. Furthermore, these domains have been proposed to be specifically altered in unaffected family members of the patients suggesting that these cognitive deficits in healthy relatives could be caused by common variants of risk for the disease [Toulopoulou et al, 2007; Owens et al, 2010; Owens et al, 2011; Goldberg et al, 2012].…”

Section: Introductionmentioning

confidence: 99%

Substantial genetic link between iq and working memory: Implications for molecular genetic studies on schizophrenia. the european twin study of schizophrenia (EUTwinsS)

Goldberg¹,

Alemany²,

Rosa³

et al. 2013

American J of Med Genetics Pt B

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While evidence is accumulating to support specific neurocognitive deficits as putative endophenotypes for schizophrenia, the heritability of these deficits in healthy subjects and whether they share common genetic influences, is not well established. In the present study, 529 healthy adult twins from two centers within the European Twin Study Network on Schizophrenia (EUTwinsS) were assessed on two domains that are consistently found to be particularly compromised in schizophrenia. Specifically, Intellectual Quotient Score (IQ) and the Letter-Number Sequencing Test (LNS), a measure of working memory, were measured in all twins. Latent variable components were explored through structural equation modeling, and common genetic underpinnings were examined using bivariate analyses. Results showed that the phenotypic correlation between IQ and working memory was almost entirely attributed to shared genetic variance (95.5%). We discuss the potential use of a combined measure of IQ and working memory to improve the power of molecular studies in detecting the genetic mechanisms underlying schizophrenia.

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Section: Introductionmentioning

confidence: 99%

Substantial genetic link between iq and working memory: Implications for molecular genetic studies on schizophrenia. the european twin study of schizophrenia (EUTwinsS)

Goldberg¹,

Alemany²,

Rosa³

et al. 2013

American J of Med Genetics Pt B

Self Cite

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“…Further, interactions between genes involved in neurovascular function or regulated by hypoxia that interacted with obstetric complications might increase the risk for schizophrenia (Nicodemus et al, 2008). On the contrary, nurturing environments providing stable affective contexts may temper early stressful experiences, which could potentially negatively influence cognitive processes in psychiatric disorders (Goldberg et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Familial liability to schizophrenia and mood disorders and cognitive impairment in psychosis

Cuesta

Zarzuela

Sánchez‐Torres

et al. 2015

Psychiatry Research

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“…This inconsistency may be brought about by the small sample sizes in some previous research, different measures of cognitive functioning, different stages of disease progression (e.g., first-episode versus chronic), different disease durations, and different treatment statuses (e.g., unmedicated versus medicated). In addition, different genetic backgrounds may play a vital role in the manifestation of the disease in EO patients and non-EO patients [39]. It can be assumed that EO may be the result of a monogenic disorder, whereas the manifestation of non-EO patients may be polygenic in nature, and may have different genetic causes for their phenotypic manifestations in different populations of subjects, resulting in different degrees of cognitive symptoms.…”

Section: Discussionmentioning

confidence: 99%

Age of Onset Moderates the Association Between Total Antioxi-Dant Capacity and Cognitive Deficits in Patients With Drug-Naïve Schizophrenia

Li¹,

Li²,

Guo³

et al. 2023

Preprint

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Schizophrenia patients with an earlier age of onset have been found to have more serious negative symptoms and cognitive deficits. Oxidative stress is thought to be implicated in cognitive impair-ment in schizophrenia. Total antioxidant capacity (TAOC) is an essential indicator of oxidative stress. However, the association between age of onset, TAOC, and cognitive performance in schizophrenia is still unexplored. In this study, 201 patients (age: 26.5±9.6 years, male: 53.2%) with drug naïve schizophrenia were recruited. Clinical symptoms were evaluated using the Positive and Negative Syndrome Scale (PANSS). Cognitive functioning was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Plasma TAOC levels were an-alyzed using established procedures. Results showed that early-onset (EO) patients had higher TAOC levels, more severe negative symptoms and performed worse on Visuospatial/Constructional, Language and RBANS total score compared with non-EO patients. After Bonferroni correction, only non-EO patients showed a significant inverse relationship between TAOC levels and RBANS language, attention, and total scores. Our findings suggest that early /late age of onset may be correlated with psychopathological symptoms, cognitive impairment and oxidative responses in schizophrenia. Furthermore, the age of onset may moderate the relationship between TAOC and cognitive function in patients with schizophrenia. These findings suggest that improving oxidative stress status in non-EO schizophrenia patients may enhance their cognitive function.

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Increased familiarity of intellectual deficits in early-onset schizophrenia spectrum disorders

Cited by 8 publications

References 46 publications

Substantial genetic link between iq and working memory: Implications for molecular genetic studies on schizophrenia. the european twin study of schizophrenia (EUTwinsS)

Substantial genetic link between iq and working memory: Implications for molecular genetic studies on schizophrenia. the european twin study of schizophrenia (EUTwinsS)

Familial liability to schizophrenia and mood disorders and cognitive impairment in psychosis

Age of Onset Moderates the Association Between Total Antioxi-Dant Capacity and Cognitive Deficits in Patients With Drug-Naïve Schizophrenia

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