“…[1][2][3] Fragments of cfDNA are released from dead cells and are present at low concentrations in body fluids, including plasma, serum, cerebrospinal fluid, and urine. 4,5 Circulating cfDNA is detectable in the plasma and serum of healthy individuals, but its levels increase after acute physical exercise, 6 during pregnancy, 7,8 and under pathologic conditions associated with increased cell death, such as inflammation, 9 myocardial infarction, 10,11 burns, 12 and transplantation rejection. 13,14 Circulating cfDNA levels are also drastically increased in patients with various cancers.…”