Increased fetal heart rate variability with acute hypoxia in chronically instrumented sheep

Parer, Julian T.; Dijkstra, Hildebrand; Vredebregt, P.P.M.; Harris, Joseph L.; Krueger, Terry R.; Reuss, Mary Lynne

doi:10.1016/0028-2243(80)90025-8

Cited by 38 publications

(30 citation statements)

References 8 publications

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“…I). Similar results were obtained by several groups both from the chronically instrumented lamb fetus and from primates [4,14,25]. Our finding of a close correlation between the change of oxygen content and the change of DI further substantiates the quantitative relation between hypoxemia and FHRV.…”

Section: Discussionsupporting

confidence: 91%

Heart rate variability and electrocardiogram changes in the fetal lamb during hypoxia and beta-adrenoceptor stimulation

Lilja¹,

Karlsson²,

Kjellmer³

et al. 1984

Journal of Perinatal Medicine

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Section: Discussionsupporting

confidence: 91%

Heart rate variability and electrocardiogram changes in the fetal lamb during hypoxia and beta-adrenoceptor stimulation

Lilja¹,

Karlsson²,

Kjellmer³

et al. 1984

Journal of Perinatal Medicine

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“…The HRV increase during moderate hyp oxia was also found in fetal lambs [10,11] and rhesus monkeys 13]. Although Stange et al [10] used a different model of hypoxia in their experimetns, the negative correla tion between PO: and HRV obtained by them is similar to the one found during the present experiment of umbilical cord clamp ing.…”

Section: Discussionsupporting

confidence: 76%

“…The decrease of HRV is often considered to be connected with fetal distress, particularly with possible hypoxia. It is thus attributed to the hypoxic depression of nervous centers regulating heart rate [7], Several experimental studies are con cerned with the mechanism of fetal and neo natal HRV [8,9] and the effect of hypoxia on it [10][11][12][13]. It is shown that the blockade of parasympathetic and/or beta-adrenergic re ceptors in the fetal [9] and the newborn [8] lamb leads to a decrease in variability.…”

mentioning

confidence: 99%

Effect of Autonomic Nervous System Blockade and Acute Asphyxia on Heart Rate Variability in the Fetal Rat

Syutkina¹

1988

Gynecol Obstet Invest

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The effect of parasympathetic (with atropine) and beta-adrenergic (with pro-pranolol) blockade on fetal heart rate variability (HRV) was studied in 162 term fetal Wistar rats. Administration of 1.3 mg of atropine into the jugular vein of the female rat led to an identical decrease of the RR interval in adult rats and in fetuses (about 10%). Administration of 2 mg of propranolol caused a rise in the RR interval by 19 % in rats and by 7–9 % in fetuses. Overall HRV indices (RMSM, CV) decrease was more pronounced in adult rats than in fetuses. Upon simultaneous administration of both blocking agents the RR interval in adult rats did not differ from the control values; in fetuses it was reduced by 6%. In adult rats HRV indices decreased considerably (by 70%) and their values were within the limits of the estimation error; in fetuses, HRV indices were no higher than upon the administration of any of the blocking agents. Umbilical cord clamping caused a decrease of PO₂ in brain tissue from 24.7 ± 1.7 to 4.7 ± 0.8 mm Hg within 15 min and led to an immediate increase of the RR interval and the HRV indices if blocking agents were not used. The administration of one or both blocking agents abolished the initial (during the first 7 min of asphyxia) increase of RMSM and CV. Thus, HRV in fetal rats depends to a great extent on the activity of the autonomic nervous system, though it is not fully determined by it. Acute asphyxia causes stimulation of the autonomic nervous system leading to fetal distress.

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“…In the heart, perinatal hypoxia was reported to induce permanent changes in the structure and function of the left ventricle (19,20). Moreover, significant changes in left ventricular gene expression were reported in newborns, with physiologic implications for the adult myocardium (21).…”

Section: Discussionmentioning

confidence: 99%

Hypoxia/reoxygenation-induced myocardial lesions in newborn piglets are related to interindividual variability and not to oxygen concentration

Faa

Iacovidou

Xanthos

et al. 2012

Clinics

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OBJECTIVE:Evaluation of myocardial histological changes in an experimental animal model of neonatal hypoxia-reoxygenation.METHODS:Normocapnic hypoxia was induced in 40 male Landrace/Large White piglets. Reoxygenation was initiated when the animals developed bradycardia (HR <60 beats/min) or severe hypotension (MAP <15 mmHg). The animals were divided into four groups based on the oxygen (O2) concentration used for reoxygenation; groups 1, 2, 3, and 4 received 18%, 21%, 40%, and 100% O2, respectively. The animals were further classified into five groups based on the time required for reoxygenation: A: fast recovery (<15 min); B: medium recovery (15-45 min); C: slow recovery (45-90 min); D: very slow recovery (>90 min), and E: nine deceased piglets.RESULTS:Histology revealed changes in all heart specimens. Interstitial edema, a wavy arrangement, hypereosinophilia and coagulative necrosis of cardiomyocytes were observed frequently. No differences in the incidence of changes were observed among groups 1-4, whereas marked differences regarding the frequency and the degree of changes were found among groups A-E. Coagulative necrosis was correlated with increased recovery time: this condition was detected post-asphyxia in 14%, 57%, and 100% of piglets with fast, medium, and slow or very slow recovery rates, respectively.CONCLUSIONS:The significant myocardial histological changes observed suggest that this experimental model might be a reliable model for investigating human neonatal cardiac hypoxia-related injury. No correlation was observed between the severity of histological changes and the fiO2 used during reoxygenation. Severe myocardial changes correlated strictly with recovery time, suggesting an unreported individual susceptibility of myocardiocytes to hypoxia, possibly leading to death after the typical time-sequence of events.

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Increased fetal heart rate variability with acute hypoxia in chronically instrumented sheep

Cited by 38 publications

References 8 publications

Heart rate variability and electrocardiogram changes in the fetal lamb during hypoxia and beta-adrenoceptor stimulation

Heart rate variability and electrocardiogram changes in the fetal lamb during hypoxia and beta-adrenoceptor stimulation

Effect of Autonomic Nervous System Blockade and Acute Asphyxia on Heart Rate Variability in the Fetal Rat

Hypoxia/reoxygenation-induced myocardial lesions in newborn piglets are related to interindividual variability and not to oxygen concentration

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