Increased Fragility Fracture Rates in Older Men With Osteomyelitis

Hsieh, Evelyn; Shiau, Stephanie; Nolan, Olivia; Gibert, Cynthia L.; Bedimo, Roger; Rodriguez‐Barradas, Maria C.; Justice, Amy C.; Womack, Julie A.; Yin, Michael T.

doi:10.1093/cid/ciz077

Cited by 10 publications

(2 citation statements)

References 12 publications

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“…Exogenous factors, such as seasonal variation, exercise, circadian rhythm, and diet, influence BTMs [ 58 , 59 ]. Also, other than primary osteoporosis, other pathological conditions are responsible for fragility fractures, such as endocrine disorders, collagen disorders, vitamin deficiencies, drugs, and hormonal therapies [ 60 , 61 , 62 , 63 , 64 , 65 ].…”

Section: Diagnostic Toolsmentioning

confidence: 99%

Fragility Fractures: Risk Factors and Management in the Elderly

et al. 2021

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Given the progressive ageing of Western populations, the fragility fractures market has a growing socioeconomic impact. Fragility fractures are common in the elderly, negatively impacting their quality of life, limiting autonomy, increasing disability, and decreasing life expectancy. Different causes contribute to the development of a fractures in frail individuals. Among all, targeting fragile patients before the development of a fracture may represent the greatest challenge, and current diagnostic tools suffer from limitations. This study summarizes the current evidence on the management of fragility fractures, discussing risk factors, prevention, diagnosis, and actual limitations of the clinical therapeutic options, putting forward new ideas for further scientific investigation.

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Section: Diagnostic Toolsmentioning

confidence: 99%

Fragility Fractures: Risk Factors and Management in the Elderly

et al. 2021

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“…Chronic inflammation has been reported to cause bone loss [ 1 , 2 ], while the underlying mechanism is not completely clear. Cellular senescence of osteogenesis cells was found to be an important cause of bone loss [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Heat-Killed Staphylococcus aureus Induces Bone Mass Loss through Telomere Erosion

Deng

Yang

et al. 2023

IJMS

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The mechanism of systemic osteoporosis caused by chronic infection is not completely clear, and there is a lack of reasonable interventions for this disease. In this study, heat-killed S. aureus (HKSA) was applied to simulate the inflammation caused by the typical clinical pathogen and to explore the mechanism of systemic bone loss caused by it. In this study, we found that the systemic application of HKSA caused bone loss in mice. Further exploration found that HKSA caused cellular senescence, telomere length shortening, and telomere dysfunction-induced foci (TIF) in limb bones. As a well-known telomerase activator, cycloastragenol (CAG) significantly alleviated HKSA-induced telomere erosion and bone loss. These results suggested that telomere erosion in bone marrow cells is a possible mechanism of HKSA-induced bone loss. CAG may protect against HKSA-induced bone loss by alleviating telomere erosion in bone marrow cells.

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Musculoskeletal Organs‐on‐Chips: An Emerging Platform for Studying the Nanotechnology–Biology Interface

Wang,

Yung,

et al. 2024

Advanced Materials

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Nanotechnology‐based approaches are promising for the treatment of musculoskeletal (MSK) disorders, which present significant clinical burdens and challenges, but their clinical translation requires a deep understanding of the complex interplay between nanotechnology and MSK biology. Organ‐on‐a‐chip (OoC) systems have emerged as an innovative and versatile microphysiological platform to replicate the dynamics of tissue microenvironment for studying nanotechnology‐biology interactions. This review covers first recent advances and applications of MSK OoCs and their ability to mimic the biophysical and biochemical stimuli encountered by MSK tissues. Next, by integrating nanotechnology into MSK OoCs, cellular responses and tissue behaviors may be investigated by precisely controlling and manipulating the nanoscale environment. Analysis of MSK disease mechanisms, particularly bone, joint, and muscle tissue degeneration, and drug screening and development of personalized medicine may be greatly facilitated using MSK OoCs. Finally, we outline future challenges and directions for the field, including advanced sensing technologies, integration of immune‐active components, and enhancement of biomimetic functionality. By highlighting the emerging applications of MSK OoCs, this review aims to advance our understanding of the intricate nanotechnology‐MSK biology interface and its significance in MSK disease management, and the development of innovative and personalized therapeutic and interventional strategies.This article is protected by copyright. All rights reserved

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Increased Fragility Fracture Rates in Older Men With Osteomyelitis

Cited by 10 publications

References 12 publications

Fragility Fractures: Risk Factors and Management in the Elderly

Fragility Fractures: Risk Factors and Management in the Elderly

Heat-Killed Staphylococcus aureus Induces Bone Mass Loss through Telomere Erosion

Musculoskeletal Organs‐on‐Chips: An Emerging Platform for Studying the Nanotechnology–Biology Interface

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