Increased Frequency of Migraine in Narcoleptic Patients: A Confirmatory Study

Abstract

Previously we have reported an increased prevalence of migraine in narcoleptic patients. Because of the theoretical and clinical implications of this finding we recruited an independent new study sample of 100 patients with proven narcolepsy and conducted a structured 26-item interview based on the international diagnostic criteria for headache disorders, the Kiel Headache Questionnaire. Narcolepsy symptoms were measured by means of the Stanford Centre for Narcolepsy Sleep Inventory. Migraine prevalence was twofold to fourfold increased in the narcoleptic patients and amounted to 44.4% in women and 28.3% in men. The onset of narcolepsy symptoms was 12.3 +/- 11.4 years before the onset of migraine symptoms. The results might be regarded as indicative of a common pathophysiological pathway relevant to both of the two disorders.

Diretrizes brasileiras para o diagnóstico de narcolepsia

“…The prevalence of migraines is greater in the narcoleptic subpopulation with more intense symptoms. 43,44 8) Narcolepsy and multiple sclerosis Narcolepsy and multiple sclerosis (MS) are both commonly associated with mutations of the HLA 0602 allele, and both are considered autoimmune disorders. Multiple sclerosis is a risk factor for narcolepsy, but the opposite is not true.…”

The Effect of Bariatric Surgery on Migraine Headache in Morbid Obese Patients

“…Serotonin moreover through various neuropeptides influences on eating behavior, such as orexin-A which is a regulating hormone for appetite and feeding, orexin-A also is related to arousal, reward center, induction of spontaneous exercise (59) so that, in obese women lower serum concentration of orexin-A was seen in comparison with control group (60), interestingly, other correlations between obesity and migraine may be through sleep dis-regulation. In narcolepsy patients which is a sleep disorder determined with orexin-A insufficiency, Both problems are prevalent conditions in narcolepsy patients (61,62).…”

Association between migraine and HLA–DRB1 gene polymorphisms

“…Epidemiological studies have shown the presence of a significant comorbidity between migraine and some diseases related to the HLA system, like asthma and narcolepsy [5,6]. This comorbidity suggests the presence, within the HLA region, of genetic factors involved in the disease pathogenesis.…”

“…Mutations in the CACNA1A and ATP1A2 genes are associated with familial hemiplegic migraine, a rare subtype of migraine with aura [3,4]. The genes involved in the more common form of migraine, like migraine with and without aura, are still unknown.Epidemiological studies have shown the presence of a significant comorbidity between migraine and some diseases related to the HLA system, like asthma and narcolepsy [5,6]. This comorbidity suggests the presence, within the HLA region, of genetic factors involved in the disease pathogenesis.…”