Increased frequency of the HLA‐DR15 (B1*15011) allele in German patients with self‐limited hepatitis C virus infection

Lechmann, Martin; Em, Schneider; Giers, G.; Kaiser, Rolf; Dumoulin, Franz Ludwig; Sauerbruch, Tilman; Spengler, Ulrich

doi:10.1046/j.1365-2362.1999.00464.x

Cited by 44 publications

(26 citation statements)

References 32 publications

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“…In addition, the study by McKiernan et al 32 also identified DRB1*0401 and DRB1*15 as protective alleles, a finding that is also supported by two British and German studies. 98,99 Strikingly, DRB1*1101 was not found to be protective in the Irish cohort by either of the studies. This marked difference between different ethnicities, the protective role of DRB1*11 in continental Europeans but not in Irish subjects, and the protective role of DRB1*01 in Irish but not continental European subjects, is further underlined by the finding that DRB1*0101 is protective in white North Americans but not Afro-American, whereas DQB1*0301 (which is in linkage disequilibrium with DRB1*1101) is protective in Afro-Americans, but not white North Americans.…”

Section: Role Of Class II Alleles In Hcv Infectionmentioning

confidence: 66%

Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infection

Thimme

2007

Genes Immun

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The immunobiology of hepatitis C virus (HCV) is significantly influenced by the host immune response to the virus, especially by virus-specific T-cell responses. Virus-specific T cells are restricted by human leucocyte antigen class I and II molecules. Of note, associations between these polymorphic loci and outcome and course of HCV infection have been reported in large and well-documented cohorts. This review will briefly summarize these studies and focus especially on the immunological and virological basis for the reported associations. The outcome and course of HCV infection is most likely determined by a complex interplay of genetic, immunological and virological factors. A better understanding of these host-virus interactions is essential not only to gain better insights into the mechanisms of viral clearance and persistence but also for the development of new antiviral vaccine strategies.

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Section: Role Of Class II Alleles In Hcv Infectionmentioning

confidence: 66%

Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infection

Thimme

2007

Genes Immun

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“…Other factors such as younger age [3,20] , female gender [21,22] , presence of hepatitis B surface antigen (HBsAg) [3,23] , certain HLA alleles [6,[24][25][26][27][28][29] , and low viral quasispecies diversity [30] have been linked to increased HCV RNA clearance. While African American ethnicity [3,25] , HCV genotype 1 [31][32][33] and co-infections with human immunodeficiency virus-1 (HIV-1) [3] , Human T-Lymphotropic Virus-1 [34] and Schistosoma mansoni [35] have been associated with lower HCV RNA clearance and higher HCV RNA levels.…”

Section: Introductionmentioning

confidence: 99%

Factors influencing a low rate of hepatitis C viral RNA clearance in heroin users from Southern China

Garten¹,

Lai²,

Zhang³

et al. 2008

WJG

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INTRODUCTIONThe hepatitis C virus (HCV) epidemic now affects over 200 million people worldwide. HCV is a single-stranded RNA flavivirus that is responsible for the majority of non-A-non-B hepatitis infections [1,2] . Natural history studies have found that 15%-59% of people who are infected with HCV will undergo spontaneous viral clearance with no further liver disease due to HCV [3][4][5][6][7][8][9][10][11] . The remaining will develop chronic HCV infection that can lead to cirrhosis, hepatocellular carcinoma and the need for a liver transplant.The exact mechanism of HCV RNA clearance is not well understood although recent studies have shown that clearance is associated with strong, broad cellular immune responses [12][13][14][15][16][17][18][19] . Other factors such as younger age [3,20] , female gender [21,22] , presence of hepatitis B surface antigen (HBsAg) [3,23] , certain HLA alleles [6,[24][25][26][27][28][29] , and low viral quasispecies diversity [30] have been linked to increased HCV RNA clearance. While African American ethnicity [3,25] , HCV genotype 1 [31][32][33] and co-infections with human immunodeficiency virus-1 (HIV-1) [3] , Human T-Lymphotropic Virus-1 [34] and Schistosoma mansoni [35] have been associated with lower HCV RNA clearance and higher HCV RNA levels. Understanding why and how individuals clear HCV is the key to developing new drugs and an effective vaccine [21] .Studies of heroin users from Guangxi Zhuang Autonomous Region in southern China have attributed the appearance and spread of HIV, HCV and other infectious agents to the change in heroin using patterns from smoking to injection [36] . Abstract AIM: To s t u d y t h e v i r o l o g i c a l a n d h o s t fa c t o r s influencing hepatitis C infection outcomes in heroin users in southern China. METHODS:HCV RNA and associated factors were analyzed among 347 heroin users from Guangxi Zhuang Autonomous Region, southern China who were hepatitis C virus (HCV) EIA positive for two or more consecutive visits. RESULTS:Using the COBAS AMPLICOR HCV TEST, a remarkably low HCV RNA negative rate of 8.6% was detected. After multivariate logistic regression analysis, HCV RNA clearance was significantly associated with the presence of HBsAg (OR = 8.436, P < 0.0001), the lack of HIV-1 infection (OR = 0.256, P = 0.038) and age younger than 25 (OR = 0.400, P = 0.029). CONCLUSION:Our study suggests HCV infection among Chinese heroin users results in high levels of viral persistence even amidst factors previously found to enhance viral clearance. Prospective studies of a possible genetic component within the Chinese population and the pathogenicity of non-genotype 1 HCV infections are needed. heroin trafficking routes into the province [37,38] . It is not clear how widespread the HCV epidemic is in China. Little seroprevalence data exists, mostly from the major cities of Beijing, Shanghai and Hong Kong and to our knowledge; no studies on HCV RNA clearance in China have been done. Studies in Yunnan Province, which borders Guangxi Zhuang Autonomous...

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“…En pacientes alemanes con infección por virus de hepatitis C, se ha encontrado que el alelo HLA-DRB1*15, específicamente el subtipo molecular DRB1* 15011, presenta una frecuencia mayor en aquellos pacientes que hicieron un cuadro autolimitado de la infección 52 , sin evolucionar a la cronicidad.…”

Section: Discussionunclassified

Susceptibilidad genética a hantavirus Andes: Asociación entre la expresión clínica de la infección y alelos del sistema HLA en pacientes chilenos

Ferrer

et al. 2007

Rev. chil. infectol.

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Increased frequency of the HLA‐DR15 (B1*15011) allele in German patients with self‐limited hepatitis C virus infection

Abstract: Our data suggest that HLA-DR15 (B1*15011) might constitute an important genetic factor for the elimination of the hepatitis C virus in Germany.

Cited by 44 publications

References 32 publications

Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infection

Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infection

Factors influencing a low rate of hepatitis C viral RNA clearance in heroin users from Southern China

Susceptibilidad genética a hantavirus Andes: Asociación entre la expresión clínica de la infección y alelos del sistema HLA en pacientes chilenos

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