Increased gray matter following mindfulness-based stress reduction in breast cancer survivors with chronic neuropathic pain: preliminary evidence using voxel-based morphometry

Hatchard, Taylor; Penta, Stephanie; Mioduzsewski, Ola; Correia, Stacey; Tissera, Talia; Brown, Olivier; Haefner, Sasha A.; Poulin, Patricia A.; Smith, Andra

doi:10.1007/s13760-022-01877-5

Cited by 10 publications

(4 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study results showed that compared with standard or (38,39). Breast cancer patients have different levels of depression, and for the loss of female characteristics after breast cancer surgery especially, the psychological response can be even higher than for the cancer (40,41).…”

Section: Discussionmentioning

confidence: 64%

“…Our study results showed that compared with standard or usual care, MBSR can effectively relieve psychological stress [MD, −1.72; 95% CI: (−2.53, −0.92); P<0.0001] and anxiety [SMD, −1.36; 95% CI: (−2.13, −0.60); P=0.0005] of breast cancer patients. MBSR can help patients to consciously perceive the present, guide them to establish positive physical reactions and emotions, cultivate acceptance, patience, trust, and other attitudes, and thereby improving patients’ cognitive level ( 38 , 39 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The efficacy of mindfulness-based stress reduction vs. standard or usual care in patients with breast cancer: a systematic review and meta-analysis of randomized controlled trials

Wu¹,

Li²,

Zhang³

2022

Transl Cancer Res TCR

View full text Add to dashboard Cite

Background: Mindfulness-based stress reduction (MBSR) has become an alternative intervention for cancer patients, but its impact on depression and quality of life (QOL) of breast cancer patients remains controversial. The aim of this study was to evaluate the effects of MBSR vs. standard or usual care to relieve psychological stress in patients with breast cancer. Methods: According to the PICOS principles, databases [PubMed, Cochrane Database, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), China Scientific Journal Database (VIP), and Wanfang Database] were searched for randomized controlled trials (RCTs) on the evaluation of MBSR vs.standard or usual care for patients with breast cancer, the outcome variables included depression, stress, anxiety, fatigue, sleep and QOL. Review Manager 5.4 was used to evaluate the effects of the results among selected articles. Forest plots and funnel plots were also performed. The risk of bias was assessed using the Cochrane Risk of Bias Tool.Results: The final analysis included 14 studies with a total of 2,224 patients (1,138 in the MBSR group and 1,086 in the control group). The overall results of risk of bias assessment showed that the reporting bias among articles was high, and other bias was relatively moderate. Funnel plots and Egger's tests showed that there was no significant publication bias. Compared with standard or usual care, MBSR effectively relieved the psychological stress [mean difference (MD)

show abstract

Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

The efficacy of mindfulness-based stress reduction vs. standard or usual care in patients with breast cancer: a systematic review and meta-analysis of randomized controlled trials

Wu¹,

Li²,

Zhang³

2022

Transl Cancer Res TCR

View full text Add to dashboard Cite

show abstract

“…There is a growing evidence base for Mindfulness-Based Interventions (MBIs) across a wide variety of conditions, including depression, 1 neuropathic pain, 2 and headache, 3 and contexts such as sports performance 4 and job burnout. 5 Mindfulness has shown particular effectiveness in patients with chronic low back pain (cLBP), indicating reductions in both pain intensity and frequency.…”

Section: Introductionmentioning

confidence: 99%

A Brief Measure of Fidelity for Mindfulness Programs: Development and Evaluation of the Concise Fidelity for Mindfulness-Based Interventions Tool

Greco,

Dore,

Weinberg

et al. 2023

Global Advances in Integrative Medicine and Health

View full text Add to dashboard Cite

Background Mindfulness research and clinical programs are widespread, and it is important that mindfulness-based interventions are delivered with fidelity, or as intended, across settings. The MBI:TAC is a comprehensive system for assessing teacher competence, yet it can be complex to implement. A standardized, simple fidelity/engagement tool to address treatment delivery is needed. Objective We describe the development, evaluation, and outcomes of a brief, practical tool for assessing fidelity and engagement in online mindfulness-based programs. The tool contains questions about session elements such as meditation guidance and group discussion, and questions about participant engagement and technology-based barriers to engagement. Methods The fidelity rating tool was developed and tested in OPTIMUM, Optimizing Pain Treatment in Medical settings Using Mindfulness. The OPTIMUM study is a 3-site pragmatic randomized trial of group medical visits and adapted mindfulness-based stress reduction for primary care patients with chronic low back pain, delivered online. Two trained study personnel independently rated 26 recorded OPTIMUM sessions to determine inter-rater reliability of the Concise Fidelity for Mindfulness-Based Interventions (CoFi-MBI) tool. Trained raters also completed the CoFi-MBI for 105 sessions. Raters provided qualitative data via optional open text fields within the tool. Results Inter-rater agreement was 77-100% for presence of key session components, and 69-88% for Likert ratings of participant engagement and challenges related to technology, with discrepancies only occurring within 2 categories: ‘very much’ and ‘quite a bit’. Key session components occurred as intended in 94-100% of the 105 sessions, and participant engagement was rated as ‘very much’ or ‘quite a bit’ in 95% of the sessions. Qualitative analysis of rater comments revealed themes related to engagement challenges and technology failures. Conclusion The CoFi-MBI provides a practical way to assess basic adherence to online delivery of mindfulness session elements, participant engagement, and extent of technology obstacles. Optional text can guide strategies to improve engagement and reduce technology barriers.

show abstract

“…A more recent study investigated MBSR effects on GMV in selected breast cancer survivors with chronic neuropathic pain from a larger RCT and found that the MBSR group ( n = 13) had greater GMV in the angular gyrus and middle frontal gyrus post-training compared to controls ( n = 10). Additionally, the MBSR group had increased GMV in the right parahippocampal gyrus whereas the control group had decreased GMV in the left parahippocampal gyrus, precuneus, middle temporal gyrus, and right cuneus from pre- to post-training [ 25 ]. In addition, MBSR effects on resting-state brain activity in chronic pain samples are lacking, although there are preliminary findings immediately at post-treatment in pain-free participants.…”

Section: Introductionmentioning

confidence: 99%

Promising Subjective and Objective Benefits of Modified Mindfulness-Based Stress Reduction Training for Chinese Adults with Chronic Pain: A Pilot Randomized Control Study

Chen,

Gao,

Shi

et al. 2023

Pain Ther

View full text Add to dashboard Cite

Introduction Mindfulness-based stress reduction (MBSR) has demonstrated its effectiveness in reducing pain-related stress in adults with chronic pain. However, the implementation of MBSR needs modifications across cultures. This pilot study reports the findings of a randomized controlled trial that investigated the effects of a culturally adaptive MBSR program on self-report and neuroimaging outcomes for chronic pain adults in China. Methods Sixty-seven participants were randomly assigned to the treatment group ( n = 40) or the treatment-as-usual group ( n = 27) group at a ratio of 1.5:1. Participants completed self-report measures of pain severity, pain interference, depression, perceived stress, pain catastrophizing, mindfulness, and resilience at baseline assessment (T1), post-treatment (T2), and 3-month follow-up (T3) assessments. Functional magnetic resonance imaging (fMRI) scanning was also performed at T1 and T3 assessments. Results For the intention-to-treat sample, the results of the mixed-effect model indicated that Group × Time interaction was significant for pain catastrophizing only ( F (2, 130) = 3.51, p = 0.033). Compared with the control group, those in the MBSR group reported greater reductions in pain catastrophizing at T2 ( d = − 0.60), though this effect was not maintained at T3 ( d = − 0.05). Additionally, the results of completer analyses found significant Group × Time interactions for pain interference ( F (2, 88) = 4.40, p = 0.015) and perceived stress ( F (2, 88) = 3.13, p = 0.048), but not for other measures. Finally, both groups exhibited decreased regional homogeneity (ReHo) in the frontal lobe, while increased ReHo in the cerebellum anterior lobe was unique to the MBSR group. Conclusions The present findings suggest that the minor modified MBSR program improves certain pain-related outcomes for Chinese adults with chronic pain. Future studies with larger samples of Chinese chronic pain patients are needed to detect the small-to-moderate benefit of MBSR on fMRI and/or other objective methods. Supplementary Information The online version contains supplementary material available at 10.1007/s40122-023-00551-9.

show abstract

Increased gray matter following mindfulness-based stress reduction in breast cancer survivors with chronic neuropathic pain: preliminary evidence using voxel-based morphometry

Cited by 10 publications

References 73 publications

The efficacy of mindfulness-based stress reduction vs. standard or usual care in patients with breast cancer: a systematic review and meta-analysis of randomized controlled trials

The efficacy of mindfulness-based stress reduction vs. standard or usual care in patients with breast cancer: a systematic review and meta-analysis of randomized controlled trials

A Brief Measure of Fidelity for Mindfulness Programs: Development and Evaluation of the Concise Fidelity for Mindfulness-Based Interventions Tool

Promising Subjective and Objective Benefits of Modified Mindfulness-Based Stress Reduction Training for Chinese Adults with Chronic Pain: A Pilot Randomized Control Study

Contact Info

Product

Resources

About