Increased H1N1 Infection Rate in Asthmatic Children

Kloepfer, Kirsten M.; Olenec, Jaime; Lee, W.; Pappas, T.E.; Liu, G.; Vrtis, R.F.; Evans, Michael D.; Gangnon, R.; Gern, James E.

doi:10.1016/j.jaci.2010.12.582

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Participants were recruited through the RhinoGen study, a large prospective study of the genetic basis of childhood susceptibility to virus-induced respiratory illness, illness severity and clearance, and virus-induced asthma exacerbations [16]. A total of 383 children, aged 4-12 years, were recruited from the general population in Madison, Wisconsin, between 2007 and 2010.…”

Section: Rhinogen Study Subjectsmentioning

confidence: 99%

Genetic associations with viral respiratory illnesses and asthma control in children

Loisel

Ahluwalia

et al. 2015

Clin Experimental Allergy

View full text Add to dashboard Cite

Background Viral respiratory infections can cause acute wheezing illnesses in children and exacerbations of asthma. Objective We sought to identify variation in genes with known antiviral and pro-inflammatory functions to identify specific associations with more severe viral respiratory illnesses and the risk of virus-induced exacerbations during the peak fall season. Methods The associations between genetic variation at 326 SNPs in 63 candidate genes and 10 phenotypes related to viral respiratory infection and asthma control were examined in 226 children enrolled in the RhinoGen study. Replication of asthma control phenotypes was performed in 2,128 children in the Copenhagen Prospective Study on Asthma in Childhood (COPSAC). Significant associations in RhinoGen were further validated using virus-induced wheezing illness and asthma phenotypes in an independent sample of 122 children enrolled in the Childhood Origins of Asthma birth cohort study (COAST). Results A significant excess of P values smaller than 0.05 was observed in the analysis of the 10 RhinoGen phenotypes. Polymorphisms in 12 genes were significantly associated with variation in the four phenotypes showing a significant enrichment of small P values. Six of those genes (STAT4, JAK2, MX1, VDR, DDX58, and EIF2AK2) also showed significant associations with asthma exacerbations in the COPSAC study or with asthma or virus-induced wheezing phenotypes in the COAST study. Conclusions We identified genetic factors contributing to individual differences in childhood viral respiratory illnesses and virus-induced exacerbations of asthma. Defining mechanisms of these associations may provide insight into the pathogenesis of viral respiratory infections and virus-induced exacerbations of asthma.

show abstract

Section: Rhinogen Study Subjectsmentioning

confidence: 99%

Genetic associations with viral respiratory illnesses and asthma control in children

Loisel

Ahluwalia

et al. 2015

Clin Experimental Allergy

View full text Add to dashboard Cite

show abstract

“…During the H1N1 influenza pandemic, two independent studies conducted in the U.S. and Australia-New Zealand showed that the majority of individuals (73%) who developed severe H1N1 influenza (i.e., were admitted to the inpatient floor or intensive care unit) had underlying chronic conditions, with asthma being the most common comorbid condition (28% and 32.7% in the U.S. and Australia-New Zealand studies, respectively). 43 , 44 In addition, Kloepfer et al 45 recently reported that compared with non-asthmatics, asthmatics displayed an increased risk for H1N1 influenza infection. Therefore, asthma might have played an important role in the epidemiology of the H1N1 influenza infection.…”

Section: Impact Of Asthma On the Risk For Emerging Microbial Infectiomentioning

confidence: 99%

Influence of Asthma Epidemiology on the Risk for Other Diseases

Juhn

2012

Allergy Asthma Immunol Res

View full text Add to dashboard Cite

Asthma is a multifactorial chronic disease affecting a significant proportion of people in the United States and worldwide. Numerous laboratory and epidemiological studies have attempted to understand the etiology and underlying mechanisms of asthma and to identify effective therapies. However, the impact of asthma on the risk for other diseases has drawn little attention. This paper discusses the potential effects of asthma as a risk factor for other diseases, explores the potential mechanisms, and reviews the implications of the findings to clinical practice, public health, and research.

show abstract