Increased healthspan and resistance to Parkinson's disease in Drosophila by boiled and freeze-dried mature silk worm larval powder

Nguyen, Phuong; Kim, Kee‐Young; Kim, A‐Young; Kim, Namsuk; Kweon, HaeYong; Ji, Sang-Deok; Koh, Young Ho

doi:10.1016/j.aspen.2016.05.003

Cited by 28 publications

(20 citation statements)

References 39 publications

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“…We also reported that SMSP has several health improvements effects such as extended healthspan and increased resistances to Parkinson's disease (Nguyen et al, 2016). Those differences in health improvements effects between FDSP and SMSP might be caused by different nutrient compositions.…”

Section: Discussionmentioning

confidence: 93%

“…The most well-known health improvement effects of Bombyx mori silkworms was controlling blood glucose levels in humans and animal models when freezedried 3 rd day of 5 th instar larval powders (FDSP) were regularly taking (Ryu et al, 2013). Recently, we also reported that steamed and freeze-dried mature silkworm larval powder (SMSP) had another health improvement effects such as extended healthspan and increase resistance to Parkinson's disease (PD) in Drosophila models (Nguyen et al, 2016). In addition, we also found that amino acid compositions and mineral contents of FDSP and SMSP were different, since FDSP and SMSP were generated from different developmental stages of silk worm larvae .…”

Section: Introductionmentioning

confidence: 99%

“…In addition to producing silk threads, Bombyx mori the mulberry silkworms have been used as producing functional foods with various health improvement effects (Ji et al, 2012;Kim et al, 2005;Nguyen et al, 2016;Oh et al, 2012;Ryu et al, 2002;Ryu et al, 2013). The most well-known health improvement effects of Bombyx mori silkworms was controlling blood glucose levels in humans and animal models when freezedried 3 rd day of 5 th instar larval powders (FDSP) were regularly taking (Ryu et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Nutrition composition differences among steamed and freeze-dried mature silkworm larval powders made from 3 Bombyx mori varieties weaving different colored cocoons

Ji¹,

Kim²,

Kweon³

et al. 2016

International Journal of Industrial Entomology

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The mulberry silkworm, Bombyx mori has been one of the most important domestic animals which have provided with silk fibers for weaving fabrics and a food for a protein and lipid source. In addition, various health improvement effects of diverse silkworm larval powders were reported. Recently we found that steamed and freeze-dried mature silkworm larval powder (SMSP) generated using white-jade (also known as Backokjam) silkworm variety extended healthspan and increased resistance to Parkinson's disease in animal models. Because the colors of cocoons in silkworm varieties were caused by altered signal transduction pathways transporting phytochemicals from intestinal lumens to silk glands, we performed the proximate, amino acid, mineral, carbohydrates, fatty acid, and cholesterol composition analyses of SMSPs of 3 silkworm varieties which were weaving light yellow, golden, and red cocoons. Although most of nutrient compositions among 3 SMSPs were similar, there were significant differences in certain amino acids, minerals, and fatty acid compositions. Red silk silkworm (RS)-SMSP had higher contents of crude proteins and total amino acids than other SMSPs. In addition, the ratio of n-3/ n-6 unsaturated fatty acids were higher than the other SMSPs. In contrast Golden silk silkworm (GS)-SMSP had higher ratio of potassium/sodium than the other SMSPs. These nutrient analysis results suggested that 3 SMSPs might have common and unique health improvement effects. Thus, further studies in the functionalities of the 3 SMSPs will reveal unknown their health improvements effects. Vol. 33, No. (1), pp. 6-14 (2016) threads were known to be caused by the accumulation of specific phytochemicals in silk glands, suggesting that silk glands in mature silkworm larvae with 3 different colors might have different nutrition components. Thus, we performed proximate, amino acid composition, mineral, carbohydrate, and fatty acid analysis to examine any difference among 3 silkworm varieties. Materials and MethodsSilkworm varieties, rearing methods, and steamed and freeze-dried mature larval powder (SMSP) processing protocols Three silkworm varieties were used in this study. Golden silk (GK) (Kang et al., 2007), Yeonnokjam (YNK) (Kang et al., 2007), and Red silk (RS) silkworms were reared with mulberry leaves at the NIAS campus in Wanju-gun, Jeollabuk-do, Korea.Mature silkworm larval powders were generated as previously published (Ji et al., 2015). Briefly, after steamed at 100°C for 130 min using an electric pressure-free cooking machine (Kum Seong Ltd., Boocheon, Korea), mature silkworm larvae were freeze-dried with a freeze-drier (FDT-8612, Operon Ltd. Kimpo, Korea) at -50°C for 24 h. The freeze-dried silkworm larvae were pulverized twice using a hammer mill (HM001, Korean Pulverizing Machinery Co. LTD., Incheon, Korea) and a disk mill (Disk Mill01, Korean Pulverizing Machinery Co. LTD) sequentially (Ji et al., 2015). Proximate analysis of SMSP generated from 3 silkworm varietiesThe amount of H2O in SMSPs generated from 3 different c...

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Nutrition composition differences among steamed and freeze-dried mature silkworm larval powders made from 3 Bombyx mori varieties weaving different colored cocoons

Ji¹,

Kim²,

Kweon³

et al. 2016

International Journal of Industrial Entomology

Self Cite

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“…Preventive effects of silkworm larval powder regarding hepatic steatosis and injury in ethanoltreated rats through elevating fatty acid β-oxidation, reducing de novo synthesis of fatty acids and inhibiting oxidative stress and inflammatory response (Hong et al, 2018) Gut microbiota effect Support of growth of the probiotic bacterium Bifidobacterium animalis and reduction in plasma TNF-α following consumption of whole cricket powder in humans, suggesting improved gut health and reduced systemic inflammation (Stull et al, 2018) Health-span and lifespan Increased health-span and lifespan of Drosophila fed mature silkworm larval powder (Nguyen et al, 2016) Lange et al…”

Section: Hypolipidemic Activitymentioning

confidence: 99%

Edible insects as a source of food bioactives and their potential health effects

Lange

Nakamura

2021

Journal of Food Bioactives

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Entomophagy (consumption of insects) is an issue of global nutritional and environmental interest. The nutritional value of insects appears to be high, since they are rich in protein and fat and provide a range of vitamins and minerals. Edible insects contain similar amounts of protein to conventional meat and higher levels of polyunsaturated fatty acids. Due to their high content of protein, micronutrients and fiber, insects could become a valuable alternative to food derived from other animals. The findings of various in vitro and in vivo animal studies suggest beneficial effects of entomophagy with respect to cardiovascular, gastrointestinal and non-communicable diseases as well as immune functions and carcinogenesis. Edible insects appear to be a promising and insufficiently explored source of macronutrients, micronutrients and food bioactives. In the course of time, some edible insects may meet the criteria of functional food ingredients. However, there is a significant lack of research investigating health outcomes in humans. The available evidence in humans, derived from randomized controlled trials, suggests a role of edible insects in the promotion of mineral status and the modulation of gut microbiota, with some prebiotic effects. High-quality clinical studies assessing efficacy, oral intake safety and allergy risk are needed.

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“…The anti-obesity effects of honey were previously reported in a rat model (75,76). The hypoglycemic effects of stingless bee honey and giant honey bee honey have been tested in rats (77)(78)(79). Royal jelly was found to ameliorate diet-induced obesity and glucose intolerance in mice (80).…”

Section: From Lab Mice To Fruit Fly Modelsmentioning

confidence: 99%

From entomophagy to entomotherapy

Chantawannakul¹

2020

Front Biosci

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Increased healthspan and resistance to Parkinson's disease in Drosophila by boiled and freeze-dried mature silk worm larval powder

Cited by 28 publications

References 39 publications

Nutrition composition differences among steamed and freeze-dried mature silkworm larval powders made from 3 Bombyx mori varieties weaving different colored cocoons

Nutrition composition differences among steamed and freeze-dried mature silkworm larval powders made from 3 Bombyx mori varieties weaving different colored cocoons

Edible insects as a source of food bioactives and their potential health effects

From entomophagy to entomotherapy

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