Increased Hippocampus–Medial Prefrontal Cortex Resting-State Functional Connectivity and Memory Function after Tai Chi Chuan Practice in Elder Adults

Tao, Jing; Liu, Jiao; Egorova, Natalia; Chen, Xiangli; Sun, Sharon; Xue, Xiehua; Hua, Jia; Zheng, Guohua; Wang, Qin; Chen, Lidian; Kong, Jian

doi:10.3389/fnagi.2016.00025

Cited by 108 publications

(141 citation statements)

References 76 publications

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“…Investigators have also found decreased functional connectivity between the right hippocampus and superior mPFC in SCD (Hu et al, 2016). In a previous study, we found that mind-body intervention can significantly modulate hippocampus-mPFC rsFC and that this change is associated with memory function changes (Tao et al, 2016). Thus, our results align with previous findings.…”

Section: Discussionsupporting

confidence: 92%

Structural and Functional Hippocampal Changes in Subjective Cognitive Decline From the Community

Liang

Zhao

Wei

et al. 2020

Front. Aging Neurosci.

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Background: Recently, subjective cognitive decline (SCD) has been described as the earliest at-risk state of Alzheimer's disease (AD), and drawn attention of investigators. Studies suggested that SCD-community individuals may constitute a more vulnerable population than SCD-clinic patients, therefore, to investigate the early changes of the brain may provide guidance for treatment of the disease. We sought to investigate the changes of structure and functional connectivity alternation of the hippocampus in individuals with SCD recruited from the community using structural and resting-state functional MRI (fMRI).Methods: Thirty-five SCD patients and 32 healthy controls were recruited. Resting-state fMRI data and high-resolution T1-weighted images were collected. Whole-brain voxelbased morphometry was used to examine the brain structural changes. We also used the hippocampal tail and the whole hippocampus as seeds to investigate functional connectivity alternation in SCD.Results: Individuals with SCD showed significant gray matter volume decreases in the bilateral hippocampal tails and enlargement of the bilateral paracentral lobules. We also found that individuals with SCD showed decreased hippocampal tail resting-state functional connectivity (rsFC) with the right medial prefrontal cortex (mPFC) and the left temporoparietal junction (TPJ), and decreased whole hippocampus rsFC with the bilateral mPFC and TPJ. These brain region and FC showing significant differences also showed significantly correlation with Montreal Cognitive Assessment (MoCA) scores.Conclusion: Individuals with SCD recruited from the community is associated with structural and functional changes of the hippocampus, and these changes may serve as potential biomarkers of SCD.

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Section: Discussionsupporting

confidence: 92%

Structural and Functional Hippocampal Changes in Subjective Cognitive Decline From the Community

Liang

Zhao

Wei

et al. 2020

Front. Aging Neurosci.

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“…Niemannand colleagues found that increases in motor fitness and regular exercise increased hippocampal volume in older adults [75]. As a further support of our findings, we found that Tai Chi Chuan exercise significantly enhanced the resting state functional connectivity between the hippocampus and medial prefrontal cortex (mPFC) [76]. Li and colleagues also found that a multimodal intervention including cognitive training, Tai Chi Chuan exercise, and group counseling improved the resting-state connectivity between the mPFC and MTL[77].…”

Section: Discussionsupporting

confidence: 85%

“…It is designed to assess global memory function as measured by memory quotient (MQ), as well as memory function subscores (mental control, picture recognition, visual reproduction, associative learning, touch, comprehension memory, digit span) [63]. In this study, we focused on the subscores of the WMS-CR since the modulation effect of Tai Chi Chuan and Baduanjin on the MQ has been published in a previous study [64]. …”

Section: Methodsmentioning

confidence: 99%

Tai Chi Chuan and Baduanjin Increase Grey Matter Volume in Older Adults: A Brain Imaging Study

Tao

Liu

et al. 2017

JAD

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The aim of this study is to investigate and compare how 12-weeks of Tai Chi Chuan and Baduanjin exercise can modulate brain structure and memory function in older adults. Magnetic Resonance Imaging(MRI) and memory function measurements (Wechsler Memory Scale-Chinese revised, WMS-CR)were applied at both the beginning and end of the study. Results showed that both Tai Chi Chuan and Baduanjin could significantly increase grey matter volume (GMV) in the insula, medial temporal lobe (MTL), and putamen after 12-weeks of exercise. No significant differences were observed in grey matter volume (GMV) between the Tai Chi Chuan and Baduanjin groups. We also found that compared to healthy controls, Tai Chi Chuan and Baduanjin significantly improved visual reproduction subscores on the WMS-CR. Baduanjin also improved mental control, recognition, touch and comprehension memory subscores of the WMS-CR compared to the control group. Memory quotient (MQ)and visual reproduction subscores were both associated with GMV increases in the putamen and hippocampus. Our results demonstrate the potential of Tai Chi Chuan and Baduanjin exercise for the prevention of memory deficits in older adults.

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“…Furthermore, a recent clinical study demonstrated that extensive practice of Tai Chi, an activity that includes attention to upright posture, improved memory performance more than walking (Mortimer et al, 2012). Another study found that Baduanjin Qigong, a less strenuous movement form that also involves attention to posture, improved memory as much as Tai Chi (Tao et al, 2016). Together, these studies suggest that it is not (only) the cardiovascular aspect of exercise that leads to memory improvement.…”

Section: Discussionmentioning

confidence: 99%

“…Little research has been done on the cognitive correlates of stooped posture. However, a recent study found that practice of Qigong, a form of mindful movement that includes a focus on upright posture, led to improvement on a test of memory (Tao et al, 2016). Therefore, an association between upright posture and memory is plausible.…”

Section: Introductionmentioning

confidence: 99%

Mobility and Upright Posture Are Associated with Different Aspects of Cognition in Older Adults

Cohen

Vasavada

Wiest

et al. 2016

Front. Aging Neurosci.

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Objectives: Aging is associated with cognitive decline, including visuomotor and memory concerns, and with motor system changes, including gait slowing and stooped posture. We investigated the associations of visuomotor performance and episodic memory with motor system characteristics in healthy older adults.Methods: Neurologically healthy older adults (N = 160, aged 50–89) completed a battery of cognitive and motor tasks. Cognitive variables were grouped by principal components analysis (PCA) into two components: visuomotor performance and verbal episodic memory. Our primary predictor variables were two aspects of motor function: timed-up-and-go (TUG) speed and neck angle. Additional predictor variables included demographic factors (age, sex and education) and indicators of physical fitness (body mass index/BMI and grip strength). All seven predictor variables were entered stepwise into a multiple regression model for each cognitive component.Results: Poor visuomotor performance was best predicted by a combination of advanced age, high BMI and slow TUG, whereas poor verbal memory performance was best predicted by a combination of advanced age, male sex, low education and acute neck angle.Conclusions: Upright posture and mobility were associated with different cognitive processes, suggesting different underlying neural mechanisms. These results provide the first evidence for a link between postural alignment and cognitive functioning in healthy older adults. Possible causal relationships are discussed.

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Increased Hippocampus–Medial Prefrontal Cortex Resting-State Functional Connectivity and Memory Function after Tai Chi Chuan Practice in Elder Adults

Cited by 108 publications

References 76 publications

Structural and Functional Hippocampal Changes in Subjective Cognitive Decline From the Community

Structural and Functional Hippocampal Changes in Subjective Cognitive Decline From the Community

Tai Chi Chuan and Baduanjin Increase Grey Matter Volume in Older Adults: A Brain Imaging Study

Mobility and Upright Posture Are Associated with Different Aspects of Cognition in Older Adults

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