Increased HPA axis response to psychosocial stress in remitted depression: the influence of coping style

Höhne, Nina; Poidinger, Maximilian; Merz, Franziska; Brückl, Tanja; Zimmermann, Petra; Uhr, Manfred; Holsboer, Florian; Ising, Marcus

doi:10.1016/j.biopsycho.2014.09.008

Cited by 52 publications

(25 citation statements)

References 44 publications

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“…These findings differ from previous studies showing abnormalities in the HPA axis exist even during periods of euthymia in MDD (Hohne et al, 2014; Holsen et al, 2013; Keating et al, 2013; Lok et al, 2012). It is possible that we were unable to detect this effect in our small sample powered only to detect large effect sizes.…”

Section: Discussioncontrasting

confidence: 99%

“…More detailed investigations of HPA axis function in individuals with depression across time have led to conflicting results, with some studies finding a return to normal functioning of the HPA axis after successful antidepressant treatment (Anacker, Zunszain, Carvalho, & Pariante, 2011; Pariante, 2009; Ruhe et al, 2015; Schule, 2007) or during periods of euthymia (Lange et al, 2013) and others reporting abnormalities of HPA axis function even during periods of remission from depression, including both hyper-reactivity (Hohne et al, 2014; Holsen et al, 2013; Keating, Dawood, Barton, Lambert, & Tilbrook, 2013; Lok et al, 2012) and hypo-reactivity (Ahrens et al, 2008; Bagley, Weaver, & Buchanan, 2011) of the HPA axis. Studies evaluating HPA axis reactivity in individuals with histories of early life stress have more consistently demonstrated persistent hyperreactivity of the HPA axis over time irrespective of current psychopathology/symptoms (Heim, Newport, Mletzko, Miller, & Nemeroff, 2008), leading to the hypothesis that the finding of HPA axis hyperreactivity in individuals with depression represents an underlying biological predisposition to depression shaped by early life events rather than a transient biomarker of depressive symptoms (Pariante & Lightman, 2008).…”

Section: Introductionmentioning

confidence: 99%

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HPA axis reactivity to pharmacologic and psychological stressors in euthymic women with histories of postpartum versus major depression

Ferguson¹,

Florio

Pearson

et al. 2017

Arch Womens Ment Health

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Purpose It is unclear whether women with a history of postpartum depression (PPD) have residual, abnormal hypothalamic-pituitary-adrenal (HPA) axis reactivity, as has been reported in major depression (MDD). Further unclear is whether the abnormalities in HPA axis reactivity associated with MDD represent a stable, underlying predisposition or a state-dependent phenomenon. This study sought the following: 1) to determine if euthymic postpartum women with a history of depression have an abnormal HPA axis reactivity to pharmacologic and psychological challenges and 2) to compare HPA reactivity in women with histories of PPD versus MDD. As a secondary objective, we wanted to determine the influence of trauma history on HPA axis function. Methods Forty-five parous (12–24 months postpartum), euthymic women with history of MDD (n=15), PPD (n=15) and controls (n=15) completed pharmacologic (dexamethasone/CRH test [DEX/CRH]) and psychological (Trier Social Stress Test [TSST]) challenges during the luteal phase. Outcome measures were cortisol and adrenocorticotropic hormone (ACTH) response after DEX/CRH, and blood pressure, heart rate, epinephrine, norepinephrine, and cortisol response during the TSST. Results All groups had robust cortisol and ACTH response to DEX/CRH and cortisol response to TSST. Groups did not differ significantly in cortisol or ACTH response to DEX/CRH or in blood pressure, heart rate, epinephrine, norepinephrine, or cortisol response to TSST. Cortisol/ACTH ratio did not differ significantly between groups. Trauma history was associated with decreased cortisol response to DEX/CRH in women with histories of MDD, which was not significant after correction (F8,125, p=0.02, Greenhouse-Geisser corrected p= 0.11). Conclusions Currently euthymic women with histories of MDD or PPD did not demonstrate residual abnormal stress responsivity following administration of either a pharmacologic or psychological stressor.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

HPA axis reactivity to pharmacologic and psychological stressors in euthymic women with histories of postpartum versus major depression

Ferguson¹,

Florio

Pearson

et al. 2017

Arch Womens Ment Health

View full text Add to dashboard Cite

show abstract

“…Rather, depression is often a chronic condition due to a high recurrence rate (15-year recurrence rate of 85% in mental health settings and 35% in the general population) (54) and frequent persistence of residual symptoms after remission of a depressive episode (55). Moreover, adults with a lifetime history of depression, but currently in remission, also exhibit altered and potentially atherogenic responses to stress (56). Consequently, adults with a lifetime depressive disorder, whether ongoing or in remission, may be particularly vulnerable to the cardiotoxic effects of stressful life events.…”

Section: Discussionmentioning

confidence: 99%

Number of recent stressful life events and incident cardiovascular disease: Moderation by lifetime depressive disorder

Berntson

Patel

Stewart

2017

Journal of Psychosomatic Research

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Objective We investigated whether number of recent stressful life events is associated with incident cardiovascular disease (CVD) and whether this relationship is stronger in adults with a history of clinical depression. Methods Prospective data from 28,583 U.S. adults (mean age = 45 years) initially free of CVD who participated in Waves 1 (2001–2002) and 2 (2004–2005) of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) were examined. Number of past-year stressful life events (Wave 1), lifetime depressive disorder (Wave 1), and incident CVD (Wave 2) were determined by structured interviews. Results There were 1,069 cases of incident CVD. Each additional stressful life event was associated with a 15% increased odds of incident CVD [Odds Ratio (OR) = 1.15, 95% Confidence Interval (CI): 1.11, 1.19]. As hypothesized, a stressful life events by lifetime depressive disorder interaction was detected (P = 0.003). Stratified analyses indicated that stressful life events had a stronger association with incident CVD among adults with (OR = 1.18, 95% CI: 1.10, 1.27, n = 4,908) versus without (OR = 1.10, 95% CI: 1.07, 1.14, n = 23,675) a lifetime depressive disorder. Conclusion Our findings suggest that a greater number of recent stressful life events elevates the risk of new-onset CVD and that this risk is potentiated in adults with a history of clinical depression.

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“…In support of these dynamic causal relationships, Glannon cites a research study (Höhne et al, 2014) that operationalizes “psychosocial stress” with an experimental paradigm known as The Trier Social Stress Test (TSST) . The TSST is “a public speaking task involving a mock job interview and mental arithmetic” (2014, p. 269).…”

mentioning

confidence: 99%

A Response to: Commentary: Stabilizing Constructs through Collaboration across Different Research Fields as a Way to Foster the Integrative Approach of the Research Domain Criteria (RDoC) Project

Sullivan

2016

Front. Hum. Neurosci.

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Increased HPA axis response to psychosocial stress in remitted depression: the influence of coping style

Cited by 52 publications

References 44 publications

HPA axis reactivity to pharmacologic and psychological stressors in euthymic women with histories of postpartum versus major depression

HPA axis reactivity to pharmacologic and psychological stressors in euthymic women with histories of postpartum versus major depression

Number of recent stressful life events and incident cardiovascular disease: Moderation by lifetime depressive disorder

A Response to: Commentary: Stabilizing Constructs through Collaboration across Different Research Fields as a Way to Foster the Integrative Approach of the Research Domain Criteria (RDoC) Project

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