Increased Hydrogen Peroxide in the Expired Breath of Patients with Acute Hypoxemic Respiratory Failure

Sznajder, J. I.; Fraiman, A.; Hall, Jesse B.; Sanders, William E.; Crawford, Gregory P.; Nahum, Avi; Wood, L. D. H.

doi:10.1378/chest.96.3.606

Cited by 214 publications

(132 citation statements)

References 23 publications

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“…Another study has reported depressed levels of alveolar fluid glutathione levels in patients with ARDS (38), which suggests that antioxidant deficiency may contribute to lung damage in sepsis. This is consistent with prior experimental studies showing that administration of oxidant generating systems into the rabbit lungs in vitro or in vivo will result in an experimental form of ARDS resembling that seen in human patients (39,40), and with recent reports that expiratory gas condensates of patients with ARDS contains measurable levels of H2O2 (41,42). The potential interaction of reactive oxygen species and NO to damage the lung, and the ability of systemic or inhaled antioxidants (such as N-acetyl cysteine) to prevent the oxidant mediated damage in ARDS, especially if NO inhalation therapy is likely to be employed, should be thoroughly studied.…”

Section: Rots and Nitrogen Oxide Radicals In Septic Shock And Shock Lungsupporting

confidence: 91%

Antioxidants in Infection

Keusch

1993

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryEndogenous oxidation reactions are essential for the normal biochemistry of life and are especially critical for leukocyte microbial killing mechanisms in host defense to infectious diseases. However, reactive oxidative intermediates can damage normal tissues unless kept under antioxidant control. Three selected examples of oxidant-antioxidant systems involved in infectious diseases are discus sed, regulation of molecular iron catalyzed oxidations, superoxide scavengers and inhibitors of nitric oxide synthase in septic shock, and the use of glutathione replacement therapy in HIV infection and AIDS. The data suggest that antioxidants, and therapy based on increasing antioxidant potential, have a major impact on clinical infectious diseases.

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Section: Rots and Nitrogen Oxide Radicals In Septic Shock And Shock Lungsupporting

confidence: 91%

Antioxidants in Infection

Keusch

1993

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…With the present system we obtain a detection limit for hydrogen peroxide of 8 ppb in the absence of water, and of 130 ppb in the presence of nearly 3 % of water, both in 1 s. Considering the three orders of magnitude shorter acquisition time, this sensitivity is far better than that of any other technique currently used for detection of H 2 O 2 in breath, and allows detection of H 2 O 2 at levels sufficient for detection of acute respiratory distress syndrome [67,68]. Highly sensitive detection of H 2 O 2 is also of interest in atmospheric chemistry applications [86,87], where the molecule has a significant role as a stratospheric reservoir for HO x [88,89], and is associated with biomass burning [90,91].…”

Section: Discussionmentioning

confidence: 85%

“…One example is the hydrogen peroxide (H 2 O 2 ) molecule, whose increased presence in human breath could indicate oxidative stress in the lungs [61,62]. Detection of elevated levels of H 2 O 2 can be used for early diagnosis and monitoring of such diseases as asthma [63][64][65], chronic obstructive pulmonary disease [66], or acute respiratory distress syndrome [67,68], a severe inflammatory condition with up to 50 % mortality [69]. The detection of H 2 O 2 in human breath is most commonly performed by the creation of breath condensate and the use of spectrophotometric or spectrofluorometric methods, which achieve detection limits in the range of a few ppb to a few hundred ppb [62].…”

Section: Introductionmentioning

confidence: 99%

Cavity-enhanced optical frequency comb spectroscopy in the mid-infrared application to trace detection of hydrogen peroxide

et al. 2012

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Cavity-enhanced optical frequency comb spectroscopy in the mid-infrared application to trace detection of hydrogen peroxide. Abstract We demonstrate the first cavity-enhanced optical frequency comb spectroscopy in the mid-infrared wavelength region and report the sensitive real-time trace detection of hydrogen peroxide in the presence of a large amount of water. The experimental apparatus is based on a midinfrared optical parametric oscillator synchronously pumped by a high-power Yb:fiber laser, a high-finesse broadband cavity, and a fast-scanning Fourier transform spectrometer with autobalancing detection. The comb spectrum with a bandwidth of 200 nm centered around 3.76 µm is simultaneously coupled to the cavity and both degrees of freedom of the comb, i.e. the repetition rate and carrier envelope offset frequency, are locked to the cavity to ensure stable transmission. The autobalancing detection scheme reduces the intensity noise by a factor of 300, and a sensitivity of 5.4 × 10 −9 cm −1 Hz −1/2 with a resolution of 800 MHz is achieved (corresponding to 6.9 × 10 −11 cm −1 Hz −1/2 per spectral element for 6000 resolved elements). This yields a noise equivalent detection limit for hydrogen peroxide of 8 parts-per-billion (ppb); in the presence of 2.8 % of water the detection limit is 130 ppb. Spectra of acetylene, methane, and nitrous oxide at atmospheric pressure are also presented, A. Foltynowicz ( ) · Applied physics. B, Lasers and optics (Print),

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“…[6][7][8][9][10] This noninvasive technique has been advocated as a simple method for documenting airway inflammation. Therefore, the present study was designed to evaluate H 2 O 2 -E in healthy cigarette smokers, and to determine the acute effects of the consumption of one cigarette on H 2 O 2 -E levels.…”

Section: Discussionmentioning

confidence: 99%

“…17 Since then high H 2 O 2 -E levels have been detected under a number of different conditions such as ARDS, asthma and COPD. [6][7][8][9][10] Although such results strongly suggest a role for expired hydrogen peroxide as a marker for respiratory tract inflammation, the number of investigations and publications in the area remains small.…”

Section: Discussionmentioning

confidence: 99%