Increased Hypoxemia in Neonates Secondary to the Use of Continuous Positive Airway Pressure

Nelson, Ryan; Egan, Edmund A.; Eitzman, Donald V.

doi:10.1097/00132586-197808000-00039

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Cpap Level1

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1979

1991

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“…These results suggest that in some infants recovering from RDS, prolonged use of constant distending pressure can cause slight Po2 decrease and CO2 retention. This observation has previously been reported by Nelson et al (1977). Therefore abrupt withdrawal could have been completed earlier in the course of recovery.…”

Section: Discussionsupporting

confidence: 84%

Discontinuation of continuous positive airways pressure in infants with respiratory distress syndrome.

Hegyi¹,

Hiatt²

1979

Archives of Disease in Childhood

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Section: Discussionsupporting

confidence: 84%

Discontinuation of continuous positive airways pressure in infants with respiratory distress syndrome.

Hegyi¹,

Hiatt²

1979

Archives of Disease in Childhood

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“…An elevation of arterial PCO2 during CPAP may indicate respiratory insufficiency despite optimal CPAP. It may also indicate that overdistention of the lung and the airway has affected the pulmonary capillary blood flow (47), that a change in pulmonary perfusion and in the ventilation:perfusion ratio of some alveolar units has occurred (61), and/or that the central venous pressure is elevated (50). Proposed methods of optimizing CPAP include increasing of CPAP in 2-cm increments and measuring arterial or transcutaneous blood gases (6;26), esophageal pressure (10), or compliance (6).…”

Section: Cpap Levelmentioning

confidence: 99%

CPAP and Mechanical Ventilation

Sedin

1991

Int J Technol Assess Health Care

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Respiratory insufficiency has previously been a frequent cause of neonatal death, especially in preterm infants. As late as in 1967, Silverman and associates (66) found that in infants with hyaline membrane disease (HMD), mechanical ventilation with a body-enclosing negative pressure respirator did not improve survival. Before 1970, the mortality among infants who required respiratory therapy was high (20;46;70). At the end of the 1960s and the beginning of the 1970s, several new methods were introduced to improve ventilation of newborn infants. Kirby and coworkers (41) introduced intermittent mandatory ventilation as a way of weaning from mechanical ventilation. In a series of studies, Reynolds and coworkers evaluated the effects of different peak airway pressures, respiratory frequencies, and inspiratory:expiratory ratios on arterial blood gases and right to left shunts (32;58;59;60).

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Increased Hypoxemia in Neonates Secondary to the Use of Continuous Positive Airway Pressure

Cited by 2 publications

References 0 publications

Discontinuation of continuous positive airways pressure in infants with respiratory distress syndrome.

Discontinuation of continuous positive airways pressure in infants with respiratory distress syndrome.

CPAP and Mechanical Ventilation

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