INCREASED IgA IN SCHIZOPHRENIC PATIENTS

Strahilevitz, Meir; Davis, StarkeyD.

doi:10.1016/s0140-6736(70)92909-0

Cited by 34 publications

(7 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Even though deviations in serum immunoglobulins have been found in other psychiatric patients as well (Solomon et al (1969)), it appears that the immunology of schizophrenia also has specific characteristics. Strahilevitz & Davis (1970) found that IgA was significantly higher in schizophrenic patients than in normal persons and controls with other psychiatric disorders. Solomon et al (1966) found that in chronic schizophrenics the severity of psychotic symptoms had a negative correlation to the total gammaglobulin concentration and a positive correlation to the 19-S macroglobulin concentration.…”

mentioning

confidence: 87%

Immunoglobulins, psychopathology and prognosis in schizophrenia

Pulkkinen

1977

Acta Psychiatr Scand

View full text Add to dashboard Cite

On admission, IgA, IgG and IgM concentrations were determined in 76 schizophrenics, and the correlations of these concentrations to the variables relating to psychopathology, background and prognosis were investigated in the present study, which is a part of a more extensive unpublished study. On the basis of factorization, the highest IgM concentrations were found in withdrawn schizophrenics and the lowest in paranoid schizophrenics. Of the background variables, the patient's present age had a positive correlation and his place of birth (rural-urban) a negative correlation to IgA concentrations, both being at a statistically significant level. IgA and IgM values higher than average at the beginning of treatment predicted a short hospital stay. Earlier, these patients had also needed little hospital care in relation to the duration of the disease. A hypothesis based on the results is presented, according to which a different way of reacting to stress may explain the differences in IgM concentrations in withdrawn and paranoid schizophrenics. The connection between prognosis and immunoglobulins was considered at least partially explainable on the grounds of age at the onset of the disease.

show abstract

mentioning

confidence: 87%

Immunoglobulins, psychopathology and prognosis in schizophrenia

Pulkkinen

1977

Acta Psychiatr Scand

View full text Add to dashboard Cite

show abstract

“…Abramsky and Litvin (1978) and again Knight (1982) postulated that antidopamine receptor antibodies might be the cause of schizophrenia. Several other studies reported changes in blood and CSF immunoglobulin levels of schizophrenic patients (Solomon et al, 1969;Strahilevitz et al, 1970Strahilevitz et al, , 1976Pulkkinen, 1977;de Lisi et al, 1981;Ahokas et al, 1985;Legros et al, 1985).…”

Section: Introductionmentioning

confidence: 95%

Failure to detect dopamine receptor IgG autoantibodies in sera of schizophrenic patients

Kirchbach

Fischer

Kornhuber

1987

J. Neural Transmission

View full text Add to dashboard Cite

show abstract

“…In addition, they showed that patients with IgG and IgA levels below the mean value were significantly more likely to show clinical improvement during hospitaliza tion irrespective of phenothiazine administra tion. Increased serum IgA levels but no signifi cant changes in IgG or IgM values were found in newly admitted schizophrenic individuals (Strahilevitz et al, 1970). Del Vecchio et al (1975) demonstrated that chronic schizophren ics with a family history of schizophrenia had a significantly higher serum IgA level than chronic schizophrenics without a familial clustering of the disease.…”

Section: Discussionmentioning

confidence: 99%

An Immunological Basis of Schizophrenia and Affective Disorders?

et al. 1980

View full text Add to dashboard Cite

In 48 patients with schizophrenia and 32 patients with affective disorders, different immune parameters were tested. Compared to blood-donors, IgG and IgM serum concentrations were increased in both the schizophrenic and affective disorders. However, these abnormalities did not differ from hospital control populations. The patients failed to show an association of antibodies considered to be characteristic of autoimmune diseases. In addition, no increased incidence of circulating immune complexes was detected. The only substantial serologic abnormality found was an elevation of C4 levels in patients with bipolar psychosis.

show abstract

INCREASED IgA IN SCHIZOPHRENIC PATIENTS

Cited by 34 publications

References 2 publications

Immunoglobulins, psychopathology and prognosis in schizophrenia

Immunoglobulins, psychopathology and prognosis in schizophrenia

Failure to detect dopamine receptor IgG autoantibodies in sera of schizophrenic patients

An Immunological Basis of Schizophrenia and Affective Disorders?

Contact Info

Product

Resources

About