1980
DOI: 10.1016/0002-9343(80)90003-0
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Increased immunoglobulin-secreting cells in the blood of patients with active systemic lupus erythematosus

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Cited by 160 publications
(44 citation statements)
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“…Of the 46 patients examined, 16 had active disease (as determined by a previously described visual analog scale [3,251), while 30 had inactive lupus. Seventy-eight percent of the patients were female, and their mean age was 36.…”
Section: Methodsmentioning
confidence: 99%
“…Of the 46 patients examined, 16 had active disease (as determined by a previously described visual analog scale [3,251), while 30 had inactive lupus. Seventy-eight percent of the patients were female, and their mean age was 36.…”
Section: Methodsmentioning
confidence: 99%
“…One of the main features of immunologic abnormalities is B cell hyperactivity leading to the production of large amounts of Ig and various kinds of autoantibodies (Blaese et al 1980;Smith and Steinberg 1983). Recently, evidence has been accumulated to show that the growth of B cells and their differentiation into antibody producing cells require several soluble factors.…”
mentioning
confidence: 99%
“…The hypergammaglobulinemia, autoantibody formation, and elevated antibody titers to exogenous antigens that characterize this disorder are accompanied by increased numbers of circulating B cells endogenously activated to secrete immunoglobulin (1)(2)(3)(4)(5) or specific antibodies (6)(7)(8). Most investigators have found T cell function to be impaired with respect to mitogen, antigen, or allogeneic lymphocyte responsiveness (9-12); generation of T suppressor cell activity (13-16); and autologous mixed lymphocyte reactivity (17).…”
mentioning
confidence: 99%