Increased Incidence of Anxiety and Depression During Bone Marrow Transplantation

Illescas-Rico, Renato; Amaya-Ayala, Fernando; Jiménez-López, José Luis; Caballero-Méndez, Martha E; González-Llaven, J

doi:10.1016/s0188-4409(01)00363-0

Cited by 13 publications

(6 citation statements)

References 18 publications

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“…12,13 A severe limitation of these studies of depression and anxiety is the fact that they are often based on small sample sizes of less than 30 patients 4,7,14 and short follow-up between 14 and 100 days post HSCT. 5,7,13 In prospective studies with long-term follow-up including a baseline measurement before transplantation, investigating between 61 15 and 319 HSCT patients 10 or a first measurement at 1 year after HSCT including 415 HSCT patients, 16 the level of depression and anxiety did not change significantly at 1-3, 4 or 5 years of follow-up. 12 Furthermore, prevalence rates of depression and anxiety in a cross-sectional assessment with the mean followup of 3-5 years after HSCT were similar to rates of an age-and gender-matched population sample (N = 52 000).…”

Section: Introductionmentioning

confidence: 99%

“…3 Across prospective studies of depression in HSCT patients, it has been shown that the highest risk of depression is just before transplantation procedures are carried out 4 or during hospitalization shortly after the transplantation. [5][6][7] Moreover, it has been indicated that depression and anxiety can become chronic years after the transplantation. 8,9 In a cross-sectional assessment of 662 HSCT patients (mean follow-up 7 years), a fourfold increased risk of depression was observed compared with an age-and gendermatched peer-nominated control sample.…”

Section: Introductionmentioning

confidence: 99%

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Depression and anxiety following hematopoietic stem cell transplantation: a prospective population-based study in Germany

Kuba

Esser

Mehnert

et al. 2017

Bone Marrow Transplant

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In this prospective multicenter study, we investigated the course of depression and anxiety during hematopoietic stem cell transplantation (HSCT) until 5 years after transplantation adjusting for medical information. Patients were consulted before HSCT (n=239), at 3 months (n=150), 12 months (n=102) and 5 years (n=45) after HSCT. Depression and anxiety were assessed with the Hospital Anxiety and Depression Scale (HADS). Detailed medical and demographic information was collected. Prevalence rates were compared with an age- and gender-matched control group drawn from a large representative sample (n=4110). The risk of depression before HSCT was lower for patients than for the control group (risk ratio (RR), 0.56; 95% confidence interval (CI), 0.39/0.81). Prevalence rates of depression increased from 12 to 30% until 5 years post HSCT. Anxiety rates were most frequently increased before HSCT (29%, RR, 1.31; 95% CI, 1.02/1.68) and then reached a stable level comparable to the background population (RR 0.83, 95% CI, 0.56/1.22). This study confirms the low levels of depression in the short term after HSCT and identifies depression as a long-term effect. Furthermore, it confirms previous results of heightened anxiety before HSCT. Surveillance of symptoms of anxiety during the short-term phase of HSCT and of depression during the following years is crucial.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Depression and anxiety following hematopoietic stem cell transplantation: a prospective population-based study in Germany

Kuba

Esser

Mehnert

et al. 2017

Bone Marrow Transplant

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“…There is growing evidence that SWD greatly diminishes quality of life (QOL) [4,11,12], psychological status [3], and functioning [1], and can lead patients to abandon cancer treatments [13]. Research suggests HSCT recipients with SWD experience fatigue [14], psychological distress [15,16] including fear of cancer recurrence (FCR; [17], depression, and anxiety [3,15]. SWD and FCR are leading concerns in cancer survivorship.…”

Section: Introductionmentioning

confidence: 99%

Sleep-wake Disturbance following Allogeneic Hematopoietic Stem Cell Transplantation: Trajectory and Correlates

VEERAPUTHIRAN

Gernat

Nancharaiah³

et al. 2022

Preprint

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Adults undergoing allogeneic hematopoietic stem-cell transplant (HSCT) experience progressive physical and psychosocial distress in early stages post-HSCT, including sleep-wake disturbance (SWD), psychological distress, and fatigue. We conducted a longitudinal feasibility study to determine severity/trajectory of SWDs and investigated relationships among actigraphic sleep parameters, sleepiness, insomnia severity, fear of cancer recurrence (FCR), anxiety, depression, and fatigue at 100 (T1), 150 (T2), and 180 days (T3) post-HSCT. Eight adults enrolled. Median total sleep time (TST) at T1–T3 days was adequate (7.24, 7.17, and 7.09 hours), but sleep efficiency (SE) was suboptimal (78.9%, 78.5%, 83.67%). Median Epworth Sleepiness Scale (ESS) and Insomnia Severity Index (ISI) scores indicated minimal drowsiness and subclinical insomnia at T1–T3. Median FCR Inventory (FCRI) scores indicate diminishing FCR over time. Median scores across time for anxiety (48.05, 50.2, and 44.1) and depression (44.9, 41, and 41) suggest moderate–mild distress with slight fluctuations. Surprisingly, fatigue scores increased from T1–T3 (46, 50.9, and 52.1). Increases in ISI and FCRI scores were associated with modest increases in anxiety. Findings suggest the need to evaluate and address sleep, psychological distress, and fatigue in HSCT recipients. Larger studies to confirm prevalence of SWD and association with psychological factors are warranted.

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“…Kidney transplantation is the treatment of choice for patients suffering from end-stage renal disease (ESRD), with recipients experiencing increased longevity and improved quality of life relative to patients on dialysis [5]. It is expected that in successful transplantation, the recipient's QoL improves in all aspects [6], yet since the first organ transplantation in the 1950s, there have been reports that patients who underwent organ transplantation had a poor quality of life and prognosis if they were depressed and/or anxious prior to transplantation [7]. Psychiatric disorders such as depression and anxiety may be seen after a successful renal transplantation, and its frequency is quite higher in renal transplantation patients in comparison to others [8].…”

Section: Introductionmentioning

confidence: 99%

Quality of life in a sample of Egyptian renal transplant recipients

Rasheed

Khedr

Naguib

et al. 2020

Middle East Curr Psychiatry

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Background: Poor quality of life has been reported after renal transplantation. So, we aimed to identify the quality of life and its demographic and clinical correlates among Egyptian renal transplant recipients. A cross-sectional observational study of 230 post-renal transplantation recipients (PRTRs) who were recruited from Ain Shams University Specialized Hospital and Nasser Institute nephrology clinics. All cases were subjected to a designed questionnaire for PRTRs, the semi-structured questionnaire for renal transplant recipients and the Arabic version of the World Health Organization Quality of Life Questionnaire (WHOQOL-100). Results: All the PRTRs had unsatisfactory social quality of life (QoL) while 97.8% had unsatisfactory overall QoL; moreover, 92.6% were not satisfied as regards environmental and independence QoL. Psychological dissatisfaction was met in 75.7% of all subjects, whereas the least dissatisfaction rate was the spiritual QoL (15.2%). Younger age groups were the most who complained of unsatisfactory quality of life in all domains except the spiritual QoL. All domains of QoL were found not statistically associated with gender, marital status, or social class. Subjects who received higher education had better psychological and independence QoL. The overall QoL and physical QoL were found to be correlated only with age. The psychological and independence QoL were positively correlated with age, sex, educational level, and occupation while the environmental QL was found to be positively correlated with occupation. Conclusion: The prevalence of unsatisfactory quality of life is quite high among PRTRs. Our findings pointed to the need of recognizing quality of life among renal transplant recipients, and we suggest that mental health professionals should be included in the multidisciplinary team.

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Increased Incidence of Anxiety and Depression During Bone Marrow Transplantation

Cited by 13 publications

References 18 publications

Depression and anxiety following hematopoietic stem cell transplantation: a prospective population-based study in Germany

Depression and anxiety following hematopoietic stem cell transplantation: a prospective population-based study in Germany

Sleep-wake Disturbance following Allogeneic Hematopoietic Stem Cell Transplantation: Trajectory and Correlates

Quality of life in a sample of Egyptian renal transplant recipients

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