Increased incidence of cardiovascular events in patients with antineutrophil cytoplasmic antibody–associated vasculitides: A matched‐pair cohort study

Abstract

Objective. To explore the risk of cardiovascular disease in patients with antineutrophil cytoplasmic antibody-associated vasculitides (AAVs) and to assess contributing risk factors.Methods. In a retrospective matched-pair cohort study, 113 of 131 patients with AAVs from a vasculitis clinic registry were matched 1:1 for renal function, age at diagnosis, sex, smoking status, and previous history of a cardiovascular disease to patients with noninflammatory chronic kidney disease (CKD). Cardiovascular events were defined as acute coronary syndrome, newonset angina, symptomatic peripheral vascular disease, stroke, and transient ischemic attack.Results Conclusion. In this retrospective study, patients with AAVs appear at greater risk of cardiovascular disease, with increased risk in those with a previous history of cardiovascular disease, dialysis dependency, poor renal function at remission, or a history of smoking. Measures to reduce the risk of cardiovascular disease should be integral to the management of systemic vasculitis.

Predictors of Treatment Outcomes in ANCA-Associated Vasculitis with Severe Kidney Failure

“…After 12 months, the major cause of death was cardiovascular disease, presumably related to ESRD. Early cardiovascular events have been previously reported in association with ANCA vasculitis and are postulated to be related to active inflammation as well as underlying atherosclerosis (21)(22)(23).…”

“…The renal biopsy specimens of 153 patients were reviewed. The median number of glomeruli examined per biopsy specimen was 16 (IQR, [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. The pattern of glomerular injury according to the EUVAS schema was categorized as sclerotic in 32% of cases, focal in 6%, crescentic in 43%, and mixed class in 6%.…”

Different clinical outcomes for cardiovascular events and mortality in chronic kidney disease according to underlying renal disease: the Gonryo study

“…As the prevalence of chronic glomerulonephritis, such as immunoglobulin (Ig)A nephritis, is known to vary by ethnic background and geographical area, clarification of this issue is crucially important with respect to risk stratification of CVD and death in patients before dialysis. However, only a limited number of reports examined this issue [20,21]. The study presented here, therefore, aimed to address this issue in a cohort of nephrology clinics.…”

Thrombotic and Thromboembolic Complications in Systemic Vasculitis

“…Данные мировой литературы указывают на увеличение частоты артериальных тромбозов при АНЦА-васкулитах. По данным некоторых авто-ров, распространенность артериальных тромбозов у данной группы пациентов варьирует от 3,1 до 18,7 % [11,12]. В ходе одного из ретроспективных исследова-ний у больных с АНЦА-васкулитами было продемон-стрировано значительное увеличение риска развития таких сердечно-сосудистых осложнений, как острый коронарный синдром, стенокардия, инсульт, транзи-торная ишемическая атака, облитерирующий атеро-склероз нижних конечностей.…”