Increased Incidence of Early Onset Colorectal Cancer in Arizona: A Comprehensive 15-Year Analysis of the Arizona Cancer Registry

Abstract

Introduction The aim of this study was to investigate and analyze the incidence of early-onset colorectal cancer in Arizona, using the Arizona Cancer Registry. Methods We performed a retrospective analysis of patients with colorectal cancer reported in the Arizona Cancer Registry from 1995-2010. Outcome measure: incidence of CRC in patients younger than 50 years. Results 39,623 cases of colorectal cancer were reported to the Arizona Cancer Registry during a period of 15 years. Overall, there was a 17% decrease in the incidence of CRC. However, there was a 23% increase in incidence among patients in the age group 10-50. During the same time period, 15% and 41% increase in the incidence of colon and rectal cancer was observed, respectively. The most significant increase (102%) in overall CRC incidence was seen in the age group 10-29. The highest increase (110%) in incidence of colon cancer was observed in the same age group, while the most significant increase in incidence rates (225%) of rectal cancer was seen in the age group 30-34. Conclusion Although there is an overall decrease in incidence of colorectal cancer in Arizona, alarming increase in incidence of early-onset CRC was observed; mirroring the national trends.

Increasing Incidence of Colorectal Cancer in Adolescents and Young Adults Aged 15–39 Years in Western Australia 1982–2007: Examination of Colonoscopy History

“…However, our results are consistent with other Australian and international research (11–17) showing a rising incidence of CRC in the AYA population over recent years. To date, trends in CRC incidence among Australian AYAs have only been explored to 2010 (17), with very limited other research examining colonoscopy use and costs and benefits in the younger population.…”

“…Our findings show an increasing trend in CRC incidence in WA over 25 years; however, trends over the most recent decade could not be explored due to lack of post-2007 data as our analysis was based on an existing data source with end date of 2008. However, our results are consistent with other Australian and international research ( 11 – 17 ) showing a rising incidence of CRC in the AYA population over recent years. To date, trends in CRC incidence among Australian AYAs have only been explored to 2010 ( 17 ), with very limited other research examining colonoscopy use and costs and benefits in the younger population.…”

“…In direct contrast to trends in those over 50 years of age, an increasing incidence of CRC among adolescents and young adults (AYAs) has been reported internationally ( 11 – 15 ) as well as in Australia ( 16 , 17 ) over the past two decades. A recent report showed that from 1990 to 2010, CRC incidence increased by between 85 and 100% in Australians aged 20–29 years and by 35% in those aged 30–39 years ( 17 ).…”

Comprehensive analysis of expression profiles of long non‑coding RNAs with associated ceRNA�network involved in gastric cancer progression

“…Two upregulated lncRNAs (HOTAIR and UCA1) and two downregulated lncRNAs (LOH12CR2 and PART1) were common between the microarray, CRN and circlncRNAnet results. Several studies have previously reported that HOTAIR is an oncogene that plays a crucial role in the progression of various types of cancer (20), including gastric cancer (21,22), lung cancer (23), colorectal cancer (24), liver cancer (25), gallbladder cancer (26), breast cancer (27), cervical cancer (28), ovarian cancer (29), and prostate cancer (30). The oncogene UCA1 is known to be involved in various types of cancer, such as gastric cancer (31), breast cancer (32), bladder cancer (33) and colorectal cancer (34).…”

Prevalence of Misuse of Topical Corticosteroids Among Populations in Western Region of Saudi Arabia.

“…Topical corticosteroids (TCS) are perhaps the most widely used agents amongst the therapeutic armamentarium and have been rightly acknowledged as a wonder drug in dermatological therapy (7). They provide immediate subjective and objective relief in symptoms in almost all inflammatory dermatoses thus justifying its rampant use.…”