Increased incidence of post-term delivery and Cesarean section after frozen-thawed embryo transfer during a hormone replacement cycle

Saito, Kazuki; Miyado, Kenji; Yamatoya, Kenji; Kuwahara, Akira; Inoue, Eisuke; Miyado, Mami; Fukami, Maki; Ishikawa, Takaaki; Saito, Toki; Kubota, Toshiro; Saito, Hidekazu

doi:10.1007/s10815-017-0869-7

Cited by 30 publications

(35 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, compared with fresh ET, FET is thought to be associated with several adverse perinatal outcomes, such as increased incidences of pregnancy-induced hypertension [11][12][13], abnormal placenta formation [12,14], post-term birth [15], and macrosomia [2,16,17]. The underlying mechanism is not yet clear.…”

Section: Introductionmentioning

confidence: 99%

Increased pregnancy complications following frozen-thawed embryo transfer during an artificial cycle

Jing

Zhang

et al. 2019

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose This study aimed to clarify the risks of adverse pregnancy outcomes in patients and their offspring after frozen embryo transfer (FET) during an artificial cycle (AC). Methods We conducted a retrospective cohort study that included all FET cycles and subsequent deliveries in a single centre between August 2013 and March 2016. Pregnancy, obstetric and neonatal outcomes were compared among patients treated during an AC or a natural cycle with luteal phase support (NC-LPS). Multivariate logistic regression was performed to evaluate the relationship between endometrial preparation schemes and pregnancy, obstetric and neonatal outcomes. Results AC-FET was not a significant risk factor for clinical pregnancy rate, multiple birth rate or miscarriage rate after adjusting for potential confounders. However, AC-FET was a significant risk factor for ectopic pregnancy rate (adjusted odds ratio (AOR), 1.738; 95% confidence interval (CI), 1.086-2.781) and live birth rate (AOR, 0.709; 95% CI, 0.626-0.802). Regarding obstetric outcomes, AC-FET was found to be associated with an increased risk for hypertension disorder (

show abstract

Section: Introductionmentioning

confidence: 99%

Increased pregnancy complications following frozen-thawed embryo transfer during an artificial cycle

Jing

Zhang

et al. 2019

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…The average birth weight from HRT was significantly greater compared with NC ( 36 ). A higher risk of post-term delivery and Cesarean section were noted in patients who conceived singletons after HRT cycle compared with those who conceived after NC-FET ( 21 , 36 ). FET singletons had an increased risk of being born LGA ( 8 ), but the frequencies of macrosomia were comparable between patients after NC-FET and HRT-FET ( 21 ).…”

Section: Discussionmentioning

confidence: 89%

“…A higher risk of post-term delivery and Cesarean section were noted in patients who conceived singletons after HRT cycle compared with those who conceived after NC-FET ( 21 , 36 ). FET singletons had an increased risk of being born LGA ( 8 ), but the frequencies of macrosomia were comparable between patients after NC-FET and HRT-FET ( 21 ). Artificial hormone circumstances in frozen embryo transfer during the HRT cycle may change the placental basal plate and be causatively associated with the amount of bleeding in deliveries ( 16 ).…”

Section: Discussionmentioning

confidence: 89%

“…Moreover, FET was associated with a statistically significant higher rate of placenta accreta and PIH. Compared to natural frozen cycles, higher rates of hypertensive disorders and preeclampsia in pregnancy were detected in HRT cycles ( 14 , 15 , 21 ). Recent studies focused on the number of corpus luteum (CL) ( 14 , 35 ), which can impact obstetric outcomes.…”

Section: Discussionmentioning

confidence: 92%

“…HRT cycle is also called hormone replacement cycle (HRC), programmed cycle (PC) or artificial cycle (AC) in different literatures ( 10 , 19 – 21 ). For anovulatory women, exogenous hormone preparation is often preferred.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Maternal and Neonatal Complications After Natural vs. Hormone Replacement Therapy Cycle Regimen for Frozen Single Blastocyst Transfer

et al. 2020

View full text Add to dashboard Cite

Objective: To evaluate the maternal and neonatal complications after frozen-thawed blastocyst transfer cycles utilizing different endometrial preparation regimens. Design: This is a retrospective cohort study and a secondary analysis of a multicenter, randomized, controlled trial comparing live birth rate after fresh vs. frozen single blastocyst transfer (Frefro-blastocyst). Setting: Reproductive medicine centers. Patient(s): A total of 800 women with regular menstrual cycles undergoing their first cycle of in-vitro fertilization after frozen-thawed single blastocyst transfer. Intervention(s): Endometrium preparation was performed with a natural cycle regimen or hormone replacement therapy (HRT) cycle regimen, at the discretion of local investigators. All pregnancies were followed up until delivery. Main Outcome Measure(s): Maternal and neonatal complications. Result(s): 513 infertile patients who underwent natural cycles regimen and 287 who underwent HRT cycles regimen were analyzed. The incidences of maternal and neonatal complications were comparable between the natural cycle and HRT cycle regimen. Regarding the risk of gestational diabetes, gestational hypertension, pre-eclampsia, preterm delivery, small for gestational age and large for gestational age, the HRT cycle was still not a significant risk factor after adjusting for potential confounders. The natural cycle regimen yielded an insignificant higher total live birth rate [59.45 vs. 50.17%, P = 0.001, adjusted odds ratio (AOR) 1.366, 95% confidence interval (CI) 0.975–1.913], clinical pregnancy rate (68.23 vs. 58.89%, P = 0.008, AOR 1.406, 95% CI 0.992–1.991) and ongoing pregnancy rate (62.18 vs. 52.61%, P = 0.008, AOR 1.387, 95% CI 0.988–1.948) than did the HRT cycle regimen. However, compared to natural cycles, HRT cycles were associated with a significantly higher risk of biochemical miscarriage (6.86 vs. 18.18%, P < 0.001, AOR 0.328, 95% CI, 0.176–0.611). Conclusion(s): The incidence of maternal and neonatal complications in natural cycle and HRT cycle regimens after frozen single blastocyst transfer were comparable. Frozen-thawed single blastocyst transfer in a natural cycle was associated with lower biomedical miscarriage than the use of the HRT cycle. Clinical Trial Registration Number: Frefro-blastocyst was registered at Chinese Clinical Trial Registry, ChiCTR-IOR-14005405.

show abstract

Risk assessment of hypertensive disorders of pregnancy and other adverse pregnancy outcomes after frozen embryo transfers following an artificial cycle: A retrospective cohort study

Pohjonen,

Huhtala,

Erkinaro

et al. 2024

Intl J Gynecology & Obste

View full text Add to dashboard Cite

ObjectivesThe primary aim was to investigate if frozen embryo transfer (FET) without a corpus luteum increases the risk of hypertensive disorders of pregnancy (HDP). The secondary aim was to investigate other adverse maternal and perinatal outcomes.MethodsThis was a retrospective cohort study of 1168 singleton pregnancies and live births following a FET with either an artificial cycle (AC‐FET) (n = 631) or a natural/modified natural/stimulated cycle (CL‐FET) (n = 537) between 2012 and 2020. The data were collected from patient records. The primary outcome was HDP. Secondary outcomes included cesarean sections, placental retention problems, postpartum hemorrhage (PPH), the duration of pregnancy, birth weight, low birth weight, macrosomia, length of gestation, preterm birth, small for gestational age, and large for gestational age.ResultsIn the AC‐FET group, there was an increased incidence of pre‐eclampsia, gestational hypertension, cesarean sections, PPH over 500 and 1000 mL, and retained placental tissue, compared with the CL‐FET group. These associations remained significant in logistic regression analyses with clinically relevant adjustments.ConclusionThe risk of HDP and several other maternal complications seems to be increased after AC‐FET compared with CL‐FET. Our findings support most earlier studies regarding HDP and add to the knowledge on other maternal and perinatal risks involved in AC‐FET, including an increased risk of milder forms of placental retention. More studies are needed to confirm these findings.

show abstract

Increased incidence of post-term delivery and Cesarean section after frozen-thawed embryo transfer during a hormone replacement cycle

Cited by 30 publications

References 18 publications

Increased pregnancy complications following frozen-thawed embryo transfer during an artificial cycle

Increased pregnancy complications following frozen-thawed embryo transfer during an artificial cycle

Maternal and Neonatal Complications After Natural vs. Hormone Replacement Therapy Cycle Regimen for Frozen Single Blastocyst Transfer

Risk assessment of hypertensive disorders of pregnancy and other adverse pregnancy outcomes after frozen embryo transfers following an artificial cycle: A retrospective cohort study

Contact Info

Product

Resources

About