2018
DOI: 10.1016/j.jceh.2017.05.209
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Increased Incidence of Post-transplant Lymphoproliferative Disorder in Autoimmune Liver Disease: An Irish National Experience

Abstract: PTLD has high mortality however early diagnosis and complete remission are achievable. Our study suggests that the incidence of PTLD is increased in AiLD and notably PSC patients.

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Cited by 8 publications
(9 citation statements)
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“…We also found a significant number of PTLD, which was the second cause of neoplasia and the first cause of cancer‐related deaths ( n = 4/9). An over‐representation of autoimmune liver diseases among PTLD following LT has already been observed 25 . In line, haematological cancers have been previously determined as more frequent in AIH patients than in general population, as non‐melanoma skin cancers 26 …”
Section: Discussionmentioning
confidence: 74%
See 1 more Smart Citation
“…We also found a significant number of PTLD, which was the second cause of neoplasia and the first cause of cancer‐related deaths ( n = 4/9). An over‐representation of autoimmune liver diseases among PTLD following LT has already been observed 25 . In line, haematological cancers have been previously determined as more frequent in AIH patients than in general population, as non‐melanoma skin cancers 26 …”
Section: Discussionmentioning
confidence: 74%
“…An overrepresentation of autoimmune liver diseases among PTLD following LT has already been observed. 25 In line, haematological cancers have been previously determined as more frequent in AIH patients than in general population, as non-melanoma skin cancers. 26 Sepsis, reported as the leading cause of mortality following LT for AIH in a previous study, 8 remained the second cause in our population even after excluding early deaths.…”
Section: Causes Of Deaths N Median Time Lt1-death (Months) (Iqr) Medi...mentioning
confidence: 89%
“…[ 2 ] PTLD occurred in approximately 1% of renal allograft recipients in the year 2000, [ 7 ] and developed in approximately 3% of patients following renal transplantation in the year 2017. [ 3 ] PTLD exhibits a “U-shaped” pattern of incidence in conjunction with transplantation time, so it is subdivided into early-onset and late-onset subtypes. [ 8 ] The 2 subtypes exhibit different biological characteristics.…”
Section: Discussionmentioning
confidence: 99%
“…[ 1 , 2 ] Prompt diagnosis of PTLD is critical to prognosis, to prevent the further development of malignant lymphoma. [ 3 ] A variety of imaging methods serve different purposes in the diagnosis of PTLD, including ultrasonography (US), contrast-enhanced US (CEUS), [ 4 ] computed tomography (CT), magnetic resonance imaging (MRI), contrast-enhanced MRI (CE-MRI), [ 5 ] and positron-emission tomography/CT (PET/CT). [ 6 ]…”
Section: Introductionmentioning
confidence: 99%
“…Post-transplant lymphoproliferative disease (PTLD) is characterized by abnormal lymphoid proliferation, from benign to malignant, caused by immunosuppression following solid organ or hematopoietic stem cell transplantation (HSCT). [ 1 ] Early diagnosis of PTLD is critical for improving patient prognosis and preventing further development of malignant lymphoma [ 2 ] PTLD can be diagnosed using different imaging methods including ultrasonography (US), computed tomography (CT), contrast-enhanced computed tomography (CE-CT), magnetic resonance imaging, and position emission tomography/computed tomography. However, position emission tomography/computed tomography is radioactive and therefore, inappropriate when multiple examinations are indicated.…”
Section: Introductionmentioning
confidence: 99%