Increased Inner Ear Susceptibility to Noise Injury in Mice With Streptozotocin-Induced Diabetes

Fujita, Takeshi; Yamashita, Daisuke; Katsunuma, Sayaka; Hasegawa, Shingo; Tanimoto, Hidenori; Nibu, Ken‐ichi

doi:10.2337/db11-1845

Cited by 33 publications

(25 citation statements)

References 38 publications

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“…SGC density was determined as the number of cell nuclei per 10000 μm2 of Rosenthal’s canal. We calculated SGC density as described previously [ 16 ] in three mid-modiolar sections at 30 μm apart from each cochlea, with the average value used for each mouse.…”

Section: Methodsmentioning

confidence: 99%

A High-Fat Diet Delays Age-Related Hearing Loss Progression in C57BL/6J Mice

et al. 2015

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ObjectiveAge-related hearing loss (AHL), or presbycusis, is the most common sensory disorder among the elderly. We used C57BL/6J mice as an AHL model to determine a possible association between AHL and a high-fat diet (HFD).MethodsForty C57BL/6J mice were randomly assigned to a control or HFD group. Each group was divided into the following subgroups: 1-, 3-, 5- and 12-month groups (HFD, n = 5/subgroup; control, n = 5/subgroup). Nine CBA/N-slc mice were also used as a 12-month control (n = 5) or 12-month HFD (n = 4) group. The mice were fed a HFD or normal (control) diet throughout this study. Hearing function was evaluated at 1, 3, 5 and 12 months using auditory evoked brainstem responses (ABRs). Spiral ganglion cells (SGCs) were also counted.ResultsThe elevation of ABR thresholds (at 4 and 32 kHz) at 3 and 5 months was significantly suppressed in the HFD group compared with the control groups for C57BL/6J mice. After 12 months, the elevation of ABR thresholds was significantly suppressed in the HFD group at all frequencies for C57BL/6J mice. In contrast, CBA/N-slc mice displayed opposite outcomes, as ABR thresholds at all frequencies at 12 months were significantly elevated in the HFD group compared with the control group. For the C57BL/6J mice at 12 months, SGC numbers significantly decreased in all parts of the cochleae in the control group compared with the HFD groups. In contrast, for the CBA/N-slc mice, SGC numbers significantly decreased, particularly in the upper parts of the cochleae in the HFD group compared with the control groups.ConclusionsThe elevation in ABR thresholds and SGC loss associated with aging in the HFD-fed C57BL/6J mice were significantly suppressed compared with those in the normal diet-fed mice. These results suggest that HFD delays AHL progression in the C57B/6J mice.

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Section: Methodsmentioning

confidence: 99%

A High-Fat Diet Delays Age-Related Hearing Loss Progression in C57BL/6J Mice

et al. 2015

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“…Myers and his group had previously described morphological changes in the utricle and saccule as well. 30,31 Summary of Animal Studies Evidence for increased risk of noise and agerelated neuropathology also has been demon-strated in DM animal models 9,17,25 and is consistent with the prolonged latency and decreased amplitude of the ABR in humans with DM. 32 Possible mechanisms proposed included microangiopathy, abnormal accumulation of metabolic by-products due to mitochondrial dysfunction (e.g., oxidative stress), glutathione dysregulation, glycation, and protein synthesis dysfunction.…”

Section: Vestibular Impairment and Diabetes Mellitusmentioning

confidence: 64%

“…Wu et al 9 found that rats (STZ injected) with DM demonstrated impaired recovery from a noise-induced temporary threshold shift (TTS); this recovery was improved to control levels with insulin treatment. Fujita et al 25 showed significant changes to spiral ganglion despite preservation of hair cells following a TTS-inducing noise exposure in DM rats compared with controls.…”

Section: Noise and Diabetes Mellitus Interactionmentioning

confidence: 98%

Diabetes and Auditory-Vestibular Pathology

Elangovan

Spankovich

2019

Semin Hear

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The relationship between diabetes mellitus (DM) and the auditory/vestibular system has been investigated for more than a century. Most population-based investigations of hearing loss in persons with diabetes (PWD) have revealed a slow progressive, bilateral, high-frequency sensorineural hearing loss. Despite the growing research literature on the pathophysiology of DM-related hearing loss using various animal models and other human studies, knowledge of specific mechanism of the degenerative changes of the inner ear and/or auditory nerve is far from full elucidation. Recent investigations of the mechanisms underlying the association between hearing loss and DM suggest complex combined contributions of hyperglycemia, oxidative stress resulting in cochlear microangiopathy, and auditory neuropathy. An even lesser understood complication of DM is the effect on the vestibular system. Here we provide an overview of animal and human evidence of pathophysiological changes created by DM and its effects on auditory-vestibular anatomy and function.

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“…Diabetes mellitus–related microvascular diseases of the cochlea may lead to hearing impairment. In streptozotocin‐induced diabetic animals, thickened basement membranes in the capillaries of the stria vascularis and thickened vessel walls in the modiolus have been observed . Anatomic pathological studies of human temporal bones have demonstrated that diabetes mellitus results in microangiopathic changes of the cochlea, including atrophy of the stria vascularis and vascular involvement in the basilar membrane, although epidemiological evidence suggesting any causal link between diabetes mellitus and hearing impairment is sparse.…”

Section: Discussionmentioning

confidence: 99%