Increased interleukin-7 levels in the sera of psoriatic patients: lack of correlations with interleukin-6 levels and disease intensity

Szepietowski, Jacek C.; Bielicka, E; Nockowski, Piotr; Noworolska, A; Wa̧sik, F

doi:10.1046/j.1365-2230.2000.00727.x

Cited by 37 publications

(24 citation statements)

References 26 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…IL-7 is known to be a powerful inducer of T and B lymphopoiesis, moreover many studies link IL-7 to inflammatory diseases [21], [24], [25] and bone loss in estrogen deficiency conditions [22], [26]. Our study focused on IL-7 involvement in the spontaneous osteoclastogenesis occurring in cancer patients with osteolytic metastasis.…”

Section: Discussionmentioning

confidence: 99%

IL-7 Up-Regulates TNF-α-Dependent Osteoclastogenesis in Patients Affected by Solid Tumor

et al. 2006

View full text Add to dashboard Cite

BackgroundInterleukin-7 (IL-7) is a potent regulator of lymphocyte development, which has also significant effects on bone; in fact it is a potent osteoclastogenic factor. Some human solid tumors produce high IL-7 levels, suggesting a potential IL-7 role on tumor development and progression.MethodologyWe studied 50 male patients affected by solid tumors, and their blood samples were collected at tumor diagnosis. PBMCs were isolated and cultured with/without IL-7 to study its influence on osteoclastogenesis. Serum and cell culture supernatant IL-7 levels were measured by ELISA. The quantitative analysis of IL-7 expression on T and B cells was performed by Real-Time PCR.Principal FindingsSerum IL-7 levels were highest in osteolytic cancer patients, followed by cancer patients without bone lesions, and then healthy controls. We showed the IL-7 production in PBMC cultures and particularly in monocyte and B cell co-cultures. A quantitative analysis of IL-7 expression in T and B cells confirmed that B cells had a high IL-7 expression. In all cell culture conditions, IL-7 significantly increased osteoclastogenesis and an anti-IL-7 antibody inhibited it. We demonstrated that IL-7 supports OC formation by inducing the TNF-α production and low RANKL levels, which synergize in promoting osteoclastogenesis.ConclusionsWe demonstrated the presence of high serum IL-7 levels in patients with bone metastasis, suggesting the use of serum IL-7 level as a clinical marker of disease progression and of bone involvement. Moreover, we showed the capability of IL-7 to stimulate spontaneous osteoclastogenesis of bone metastatic patients and to induce osteoclastogenesis in cancer patients without bone involvement. These findings add further details to the disclosure of the mechanisms controlling bone metastasis in solid tumors.

show abstract

Section: Discussionmentioning

confidence: 99%

IL-7 Up-Regulates TNF-α-Dependent Osteoclastogenesis in Patients Affected by Solid Tumor

et al. 2006

View full text Add to dashboard Cite

show abstract

“…It is characterised by keratinocyte hyperproliferation and neutrophil and lymphocytic infiltration of the skin and epidermis [Christophers, 1996;Griffiths and Voorhees, 1996]. Although numerous studies have been performed, the aetiopathogenesis of psoriasis is still not fully understood [Szepietowski et al, 2000;Szepietowski et al, 2001b]. Several internal and external factors could play a role, of which psychological factors are the most important [Fava et al, 1980;Fried et al, 1995;Ginsburg, 1995;Susskind and Mc Guire, 1959;Schmid-Ott, 2000;Zrniç et al, 2001].…”

Section: Dokumentation Und Evaluation Der Weiterbildung Original Artimentioning

confidence: 99%

Stressful Life Events and Depression in Patients Suffering from Psoriasis Vulgaris

Pacan¹,

Szepietowski²,

Kiejna³

2003

Dermatol Psychosom

View full text Add to dashboard Cite

Background: Psoriasis is a chronic inflammatory skin disease. Its pathogenesis is not completely clear; there are some suggestions that psychological factors may play an important pathogenic role. Objective: To evaluate the influence of stressful life events on exacerbation of psoriasis and comorbidity of depression. Patients and Methods: 77 psoriatic individuals, aged 18–78 years, were included in the study. Stress was assessed according to the Social Readjustment Rating Scale by Holmes and Rahe. All patients underwent psychiatric examination for depression (according to ICD-10). Intensity of depression was evaluated by Hamilton and Beck scales. Results: 61% of psoriatic patients reported having experienced stressful life events in the month before exacerbation of the disease. Severity of psoriasis (Psoriasis Area and Severity Index, PASI) in patients with stressful life events (22.8 ±9.3 points) was significantly higher (p < 0.0001) compared to those without stress (14.0 ±9.2 points). There was no correlation between intensity of stress and severity of psoriasis. Depression was diagnosed in 16.9% of the patients. Psoriatic individuals suffering from depression were significantly younger (p < 0.05). No significant relationship was found between intensity of depression and the PASI score, nor between intensity of stress and severity of depression. Conclusions: More than half of the psoriatic patients studied had experienced at least one stressful life event in the month before psoriasis exacerbation. Moreover, the severity of psoriasis is significantly increased in patients with preceding stressful life events. Depression could be diagnosed in less than 20% of psoriatic patients, the majority of them suffering from reactive disorders.

show abstract

“…We found IL-6 and TNF-α to be elevated in our patient's group than in control group. Elevated serum levels of these cytokines were reported by most of the investigators [14][15][16][17]. TNF-α is produced by Langerhans cells, macrophages, monocytes, T cells and keratinocytes [18].…”

Section: Resultsmentioning

confidence: 99%

Increased Serum Levels of TNF-Α and IL-6 are not Related to HLA-Cw6 in Psoriasis Patients Correlation of Cytokine with HLA Cw6

Singh¹,

Sonkar²

2016

Transcriptomics

View full text Add to dashboard Cite

Psoriasis is a T cell mediated inflammatory skin disease. Complex network of cytokine induces and maintain the psoriatic lesion. Study was performed to evaluate the correlation between the level of TNF-α and IL-6, in the psoriasis patients with HLA-Cw6. Cytokine levels were assayed by sandwich ELISA and HLA-Cw6 typing was done by microcytoxicity method. Serum TNF-α and IL-6 were significantly (p=<0.001 in both) expressed in psoriasis patients. TNF-α had significant positive correlation with IL-6 (p=0.56, p=<0.001). We can conclude that TNF-α and IL-6 are found elevated in serum in psoriasis patients, compared to the control group. Proinflammatory cytokine such as TNF-α and IL-6 may cause inflammatory changes in microenvironment of psoriasis lesion. Gender of patient and age on onset of disease does not influence the expression of these cytokine in psoriasis cases. Results suggest that HLA-Cw6 did not influence these cytokines secretion.

show abstract

Increased interleukin-7 levels in the sera of psoriatic patients: lack of correlations with interleukin-6 levels and disease intensity

Cited by 37 publications

References 26 publications

IL-7 Up-Regulates TNF-α-Dependent Osteoclastogenesis in Patients Affected by Solid Tumor

IL-7 Up-Regulates TNF-α-Dependent Osteoclastogenesis in Patients Affected by Solid Tumor

Stressful Life Events and Depression in Patients Suffering from Psoriasis Vulgaris

Increased Serum Levels of TNF-Α and IL-6 are not Related to HLA-Cw6 in Psoriasis Patients Correlation of Cytokine with HLA Cw6

Contact Info

Product

Resources

About