Increased intestinal absorption by segmental reversal of the small bowel in adult patients with short-bowel syndrome: a case-control study

Layec, S.; Beyer, Laura; Corcos, Olivier; Alvès, Arnaud; Dray, Xavier; Amiot, Aurélien; Stéfanescu, Carmen; Coffin, Benoït; Brétagnol, F.; Bouhnik, Yoram; Messing, Bernard; Panís, Yves; Kapel, Nathalie; Joly, Francisca

doi:10.3945/ajcn.112.042606

Cited by 44 publications

(19 citation statements)

References 36 publications

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“…IEC LEPR‐B‐WT and ‐KO mice were fed an ND or HFD for 3 wk, and indirect calorimetric measurements of whole energy expenditure, oxygen consumption and carbon dioxide production, respiratory exchange rate, food intake, and locomotor activity were performed using calorimetric cages with food and water (Labmaster; TSE Systems, Bad Homburg, Germany), as described previously (26). The stools were collected for determination of excreted fats and total energy by the method of Van de Kamer and bomb calorimetry (PARR 1351 bomb calorimeter; Parr Instrument Co., Moline, IL, USA) as described previously (27, 28).…”

Section: Methodsmentioning

confidence: 99%

Intestinal deletion of leptin signaling alters activity of nutrient transporters and delayed the onset of obesity in mice

et al. 2014

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The importance of B-isoform of leptin receptor (LEPR-B) signaling in the hypothalamus, pancreas, or liver has been well characterized, but in the intestine, a unique site of entry for dietary nutrition into the body, it has been relatively ignored. To address this question, we characterized a mouse model deficient for LEPR-B specifically in intestinal epithelial cells (IECs).IEC LEPR-B-knockout (KO) and wild-type (WT) mice were generated by Cre-Lox strategy and fed a normal or high-fat diet (HFD). The analyses of the animals involved histology and immunohistochemistry of intestinal mucosa, indirect calorimetric measurements, whole-body composition, and expression and activities of nutrient transporters. IEC LEPR-B-KO mice exhibited a 2-fold increase in length of jejunal villi and have normal growth on a normal diet but were less susceptible (P<0.01) to HFD-induced obesity. No differences occurred in energy intake and expenditure between IEC LEPR-B-WT and -KO mice, but IEC LEPR-B-KO mice fed an HFD showed increased excreted fats (P<0.05). Activities of the Na ؉ /glucose cotransporter SGLT-1 and GLUT2 were unaffected in LEPR-B-KO jejunum, while GLUT5-mediated fructose transport and PepT1-mediated peptide transport were substantially reduced (P<0.01). These data demonstrate that intestinal LEPR-B signaling is important for the onset of diet-induced obesity.They suggest that intestinal LEPR-B could be a potential per os target for prevention against obesity.-

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Section: Methodsmentioning

confidence: 99%

Intestinal deletion of leptin signaling alters activity of nutrient transporters and delayed the onset of obesity in mice

et al. 2014

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“…A recent case-control study of 17 adult SBS patients who had undergone the reversed intestinal segment procedure found that the surgery resulted in a gain in macronutrient absorption and was associated with a lower parenteral nutrition dependence [22]. The same group also recently reported that in 38 adult SBS patients with a reversed jejunal segment of 10-12 cm, 45% of patients had been weaned from parenteral nutrition after 5 years of follow-up, whereas the remainder had reduced their parenteral nutrition requirements from 7 to 4 days/ week [23].…”

Section: Autologous Gastrointestinal Reconstructionmentioning

confidence: 98%

Short bowel syndrome and small bowel transplantation

DiBaise

2014

Current Opinion in Gastroenterology

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Recently available trophic factors hold promise as aids in restoring freedom from parenteral nutrition support; however, their long-term benefits, preferred timing of administration in relation to the onset of SBS, optimal patient selection for use, duration of treatment and cost effectiveness require further study. Despite recent evidence of improved early survival after SBT, more dedicated research is needed to design more effective strategies to better tolerize small bowel grafts, prevent rejection and, ultimately, improve long-term outcomes. Reserved for well selected patients, autologous gastrointestinal reconstruction should be considered complementary and not antagonistic to SBT.

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“…Ancak, 2012 ve 2013 yılında bir grup erişkin kısa bağırsak hastasında bu operasyonların etkinliği geniş bir şekilde çalışmış ve ortaya koymuştur (39,40) .…”

Section: B Anizoperistaltik Ince Bağırsak/izoperistaltik Jejunal Veyunclassified

Intestinal Failure/Nontransplant surgical interventions for short bowel syndrome

Çelik¹

2017

tcdd

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Öz GirişBağırsak sisteminin bireyin besin alımı ve sıvı dengesini sağlamada yetersiz kaldığı durumlara bağırsak yetmezliği adı verilmektedir. Bağırsak uzunluğunun azaldığı, ileoçekal valvin olmadığı, kolonun kaybedildiği gibi uzunluk kayıpları veya mukozal yetmezlik, dismotilite veya aktif enterit gibi besin emiliminin mümkün olmadığı durumlarda birey kalıcı veya uzun süreli total parenteral beslenmeye mecbur kalabilmektedir (1) . "Büyüme için gerekli sıvı ve besinlerin sindirimi ve emilimi için yeterli miktarda fonksiyonel bağırsak kalmaması" pediatrik bağırsak yetmezliğinin modern tanımlamasıdır. Bir başka tanımda ise, büyüme, hidrasyon ve elektrolit homeostazının bozulmasına neden olan bağırsak hastalığı olarak genellenebilmektedir.

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Increased intestinal absorption by segmental reversal of the small bowel in adult patients with short-bowel syndrome: a case-control study

Abstract: SRSB allows a gain in macronutrient absorption, which is associated with a lower HPN dependence. To our view, SRSB should be integrated in intestinal rehabilitative adult programs.

Cited by 44 publications

References 36 publications

Intestinal deletion of leptin signaling alters activity of nutrient transporters and delayed the onset of obesity in mice

Intestinal deletion of leptin signaling alters activity of nutrient transporters and delayed the onset of obesity in mice

Short bowel syndrome and small bowel transplantation

Intestinal Failure/Nontransplant surgical interventions for short bowel syndrome

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