Increased intima thickness of the radial artery in patients with coronary heart disease

Myredal, Anna; Osika, Walter; Gan, Li; Friberg, Peter; Johansson, Mats

doi:10.1177/1358863x09106619

Cited by 17 publications

(9 citation statements)

References 24 publications

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“…Notably, we identified a trend manifested as obvious intimal hyperplasia combined with mature plaque involving the RA in patients presenting with overt coronary disease. However, no differences in the media layer were demonstrated among our three groups, a similar observation to that made using ultrabiomicroscopy in a comparison between patients with and without CAD [ 4 ]. Xu and associates reported that RA intimal thickness measured by ultrasound biomicroscopy could detect CAD independently similarly to that of carotid intima-media thickness [ 3 ].…”

Section: Discussionsupporting

confidence: 87%

Assessment of radial artery atherosclerosis in acute coronary syndrome patients: an in vivo study using optical coherence tomography

Tang

Wang

et al. 2022

BMC Cardiovasc Disord

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Background Radial artery (RA) atherosclerosis in acute coronary syndrome (ACS) patients has not been systematically observed in vivo. The study aims to characterize plaque morphology and intimal hyperplasia of the RA in patients with ACS, using optical coherence tomography (OCT). Methods In this retrospective study involving 239 ACS patients underwent RA OCT without guidewire shadow, 3 groups were divided according to the following criteria: radial artery plaque (RAP) group included patients with fibrous, lipid or calcified plaque; patients without RAP were further classified into radial intimal hyperplasia (RIH) group (intima media thickness ratio [IMR] ≥ 1) or normal group (IMR < 1). The presence and characteristics of RAP and its related risk factors were identified. Results The RAP, RIH and normal groups included 76 (31.8%), 69 (28.9%) and 94 (39.3%) patients, respectively. Patients in RAP group were the oldest, compared with those in the RIH and normal groups (p < 0.001), and more frequently had triple vessel disease (p = 0.004). The percentage of plaque rupture (72.4% vs. 56.4%, p = 0.018) and calcification (42.1% vs. 27.6%, p = 0.026) at culprit lesion were significantly higher in patients with RAP than those without RAP. A total of 148 RAP were revealed by OCT, including fibrous (72, 48.6%), lipid (50, 33.8%) and calcified plaques (26, 17.6%). The microvessels were also frequently observed in the RAP group than that in RIH and normal groups (59.2% vs. 8.7% vs. 9.6%, p < 0.001). Multivariate logistic regression analysis showed that age, diabetes, and smoking history (all p < 0.05) were independent risk factors for RAP. Conclusions In terms of insights gained from OCT, RA atherosclerosis is not uncommon in ACS patients by OCT, sharing several morphological characters with early coronary atherosclerosis. Aging, diabetes, and smoking are risk factors for RAP.

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Section: Discussionsupporting

confidence: 87%

Assessment of radial artery atherosclerosis in acute coronary syndrome patients: an in vivo study using optical coherence tomography

Tang

Wang

et al. 2022

BMC Cardiovasc Disord

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“…A recent study of radial arteries in apparently health individuals observed that the intimal thickness was <10 μm in 90% of those studied 14 . The median vascular intimal thickness in our CKD patients was 12.5 (IQR, 6.1-26.5) μm for the arteries and 6.4 (IQR, 4.4-12.2) μm for the veins (Figure 2).…”

Section: Resultsmentioning

confidence: 92%

Correlation of Pre-existing Vascular Pathology With Arteriovenous Graft Outcomes in Hemodialysis Patients

Allon

Litovsky

Young

et al. 2013

American Journal of Kidney Diseases

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Background Arteriovenous grafts (AVGs) are prone to neointimal hyperplasia leading to AVG failure. We hypothesized that pre-existing pathologic abnormalities of the vessels used to create AVG (including venous intimal hyperplasia, arterial intimal hyperplasia, arterial medial fibrosis, and arterial calcification) are associated with inferior AVG survival. Study Design Prospective observational study. Setting & Participants Patients with chronic kidney disease undergoing placement of a new AVG at a large medical center who had vascular specimens obtained at the time of surgery (n=76) Predictor Maximal intimal thickness of the arterial and venous intima, arterial medial fibrosis, and arterial medial calcification. Outcome & Measurements Unassisted primary AVG survival (time to first intervention) and frequency of AVG interventions. Results 55 patients (72%) underwent interventions and 148 graft interventions occurred during 89.9 years of follow-up (1.65 interventions per graft-year). Unassisted primary AVG survival was not significantly associated with arterial intimal thickness (HR, 0.72; 95% CI, 0.40-1.27; p=0.3), venous intimal thickness (HR, 0.64; 95% CI, 0.37-1.10; p=0.1), severe arterial medial fibrosis (HR, 0.58; 95% CI, 0.32-1.06; p=0.6), or severe arterial calcification (HR, 0.68; 95% CI, 0.37-1.31; p=0.3). The frequency of AVG interventions per year was inversely associated with arterial intimal thickness (relative risk [RR], 1.99; 95% CI, 1.16-3.42; p<0.001 for thickness <10 vs >25 μm); venous intimal thickness (RR, 2.11; 95% CI, 1.39-3.20; p<0.001 for thickness <5 vs >10 μm); arterial medial fibrosis (RR, 3.17; 95% CI, 1.96-5.13; p<0.001 for fibrosis <70% vs ≥70%), and arterial calcification (RR, 2.12; 95% CI, 1.31-3.43; p=0.001 for <10% vs ≥10% calcification). Limitations Single center study. Study may be underpowered to demonstrate differences in unassisted primary AVG survival. Conclusions Pre-existing vascular pathologic abnormalities in CKD patients may not be significantly associated with unassisted primary AVG survival. However, vascular intimal hyperplasia, arterial medial fibrosis, and arterial calcification may be associated with a decreased frequency of AVG interventions.

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“…21 In this highly hydrated state, the collagen gel was too fragile to be handled. Puncturing the gel with the curved needle from a 10-0 suture invariably tore apart the entire gel.…”

Section: Native Collagen Gels Did Not Withstand Suturingmentioning

confidence: 99%

Generation, Endothelialization, and Microsurgical Suture Anastomosis of Strong 1-mm-Diameter Collagen Tubes

Nicolescu

et al. 2017

Tissue Engineering Part A

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Tissue-engineered vascular grafts that are based on reconstituted extracellular matrices have been plagued by weak mechanical strength that prevents handling or anastomosis to native vessels. In this study, we devise a method for making dense, suturable collagen tubular constructs of diameter £1 mm for potential microsurgical applications, by dehydrating tubes of native rat tail type I collagen and crosslinking them with 20 mM genipin. Crosslinked dense collagen tubes with 1 mm inner diameter yielded ultimate tensile strength of 342 -15 gF and burst pressure of 1313 -156 mm Hg, comparable to the strength of a rat femoral artery, and supported endothelial cell adhesion and growth. End-to-end anastomosis of 0.5-mm-diameter tubes to explanted arteries displayed anastomotic strength of 82 -21 gF, which is sufficient for surgical applications. In vivo implantation of cell-free tubes as interpositional grafts in the rat femoral circulation yielded stable anastomosis with blood flow for 20 min. Seeded dense collagen tubes represent a promising alternative to venous graft that can potentially be used to bridge between short artery stubs in replantation surgeries.

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Increased intima thickness of the radial artery in patients with coronary heart disease

Cited by 17 publications

References 24 publications

Assessment of radial artery atherosclerosis in acute coronary syndrome patients: an in vivo study using optical coherence tomography

Assessment of radial artery atherosclerosis in acute coronary syndrome patients: an in vivo study using optical coherence tomography

Correlation of Pre-existing Vascular Pathology With Arteriovenous Graft Outcomes in Hemodialysis Patients

Generation, Endothelialization, and Microsurgical Suture Anastomosis of Strong 1-mm-Diameter Collagen Tubes

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