Increased intracellular reactive oxygen species in patients with end-stage renal failure: Effect of hemodialysis

Tepel, Martín; Echelmeyer, Martin; Orie, Nelson N.; Zidek, Walter

doi:10.1046/j.1523-1755.2000.00236.x

Cited by 84 publications

(47 citation statements)

References 30 publications

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“…16,17 In fact, oxidative stress has been found even in the early stages of CKD, as reflected by plasma 8-isoprostane levels. Furthermore, oxidative stress seems to increase as CKD progresses and correlates significantly and inversely with the level of glomerular filtration rate.…”

Section: Oxidative Stress: What Is It?mentioning

confidence: 99%

Oxidative stress in renal dysfunction: mechanisms, clinical sequelae and therapeutic options

et al. 2009

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Oxidative stress has been increasingly linked to the high incidence of cardiovascular events in patients with chronic kidney disease (CKD), especially as traditional cardiovascular risk factors seem to not be able to account for the huge cardiovascular morbidity and mortality in this population group. Oxidative stress is increased in patients with renal impairment as a result of increased oxidant activity and reduced antioxidant capacity, and this is increased in a graded manner with increasing renal dysfunction. Inflammation, which is also present in CKD, further amplifies the oxidant generation process. The two clinical sequelae of oxidative stress are endothelial dysfunction and left ventricular hypertrophy, which have adverse cardiovascular consequences. With our new understanding of oxidative stress, it is now important to assess treatment options that reduce it in the hope that they reverse endothelial dysfunction and left ventricular hypertrophy and the clinical sequelae of these abnormalities.

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Section: Oxidative Stress: What Is It?mentioning

confidence: 99%

Oxidative stress in renal dysfunction: mechanisms, clinical sequelae and therapeutic options

et al. 2009

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“…CRF patients exhibit oxidative stress, 20) and reactive oxygen species have been implicated in the progressive loss of renal function. 21) However, the relationship between reactive oxygen species and the interaction of various uremic retention products has not been precisely clarified.…”

mentioning

confidence: 99%

Generation of Superoxide Anions during the Reaction of Guanidino Compounds with Methylglyoxal.

Nohara

Usui

Kinoshita

et al. 2002

CHEMICAL & PHARMACEUTICAL BULLETIN

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Uremic toxins are accumulated in the blood of patients with chronic renal failure (CRF), although alteration of the toxicity by the interaction of various uremic retention products has not been precisely clarified. In this study, we found that cytochrome c added to incubation mixtures containing guanidino compounds and methylglyoxal in phosphate buffer solution (pH 7.4) resulted in reduction of cytochrome c. Superoxide anions were generated from incubation mixtures of each guanidino compound with methylglyoxal, because the reduction was inhibited by the addition of superoxide dismutase. The incubation mixture containing each guanidino compound and methylglyoxal had different rates of generation of the superoxide anion from other mixtures. A relatively higher superoxide anion formation rate was observed in the incubation mixture containing Arg and methylglyoxal (7.9؎0.5 nmol · m ؊1 · min ؊1 ), or in the incubation mixture containing methylguanidine and methylglyoxal (6.3؎0.6 nmol · ml ؊1 · min ؊1). These findings suggest that interactions of various uremic retention products which accumulate in the blood of uremic patients may generate reactive oxygen species and may be involved in the oxidative stress observed in CRF patients. The addition of aminoguanidine, which is known to inhibit the formation of advanced glycation end products, to a mixture of guanidino compounds and methylglyoxal inhibited reactions between guanidino compounds and methylglyoxal.

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“…16,17 The association between the low level of antioxidant agents and atherogenesis and CVD mortality has been reported before. 18 Contrary to the effect of dyslipidemia and oxidative stress, there is a high-density lipoprotein (HDL)-associated phosphodiesterase, which has been shown to be inversely correlated with the risk of atherosclerosis.…”

Section: Introductionmentioning

confidence: 73%

Paraoxonase Enzyme Activity Is Enhanced by Zinc Supplementation in Hemodialysis Patients

et al. 2012

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Background and Aims: Patients on maintenance hemodialysis (HD) face an increased risk of atherosclerosis, a crucial problem and the leading cause of cardiovascular morbidity and mortality. This study was designed to evaluate the effects of zinc supplementation on paraoxonase (PON) enzyme activity in patients on HD. Methods: This double-blind randomized controlled trial was conducted from June 2005 to June 2007. Sixty HD patients were enrolled and divided into two groups: treatment (case) and control. The treatment and control groups were treated with 100 mg/day zinc or placebo, respectively, for 2 months. Serum zinc concentration was measured by atomic absorption spectrophotometry. PON activity was evaluated by spectrophotometric method. Lipid profile was determined using commercial kits, and apolipoprotein AI (Apo-AI) and B (Apo-B) levels were measured by commercial immunoturbidimetric kits. Results: In the case group, there was no significant change in the serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and Apo-B levels, while the serum levels of high-density lipoprotein (HDL), Apo-AI, and PON activity were significantly increased (p ¼ 0.02). In the control group, although significant increases were observed in the serum levels of TC, TG, and Apo-B (p ¼ 0.009, 0.019, and 0.001, respectively), the serum PON activity was significantly decreased (p ¼ 0.025) and the serum levels of HDL, LDL, and Apo-AI were not changed. At the end of intervention period, the serum level of Apo-AI and PON activity were significantly higher in the case group. Conclusions: Zinc supplementation increased both the activity of PON and the serum level of Apo-AI in the HD patients.

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Increased intracellular reactive oxygen species in patients with end-stage renal failure: Effect of hemodialysis

Abstract: Regular hemodialysis sessions using biocompatible membranes have no effect on the elevated intracellular ROS in patients with end-stage renal failure.

Cited by 84 publications

References 30 publications

Oxidative stress in renal dysfunction: mechanisms, clinical sequelae and therapeutic options

Oxidative stress in renal dysfunction: mechanisms, clinical sequelae and therapeutic options

Generation of Superoxide Anions during the Reaction of Guanidino Compounds with Methylglyoxal.

Paraoxonase Enzyme Activity Is Enhanced by Zinc Supplementation in Hemodialysis Patients

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