Increased Intracranial Pressure After Diphtheria, Tetanus, and Pertussis Immunization

Jack, Jacob

doi:10.1001/archpedi.1979.02130020109023

Cited by 5 publications

(4 citation statements)

References 4 publications

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“…[2][3][4][5][6] The largest previous series 7 preceded acellular pertussis vaccines' use and other recent changes in routine immunization schedules. Including 3 previously published cases, bulging fontanelles developed in 9 infants, shortly after receiving vaccinations 7 ; all resolved within 2 days.…”

mentioning

confidence: 99%

Transient Bulging Fontanelle after Vaccination: Case Report and Review of the Vaccine Adverse Event Reporting System

Freedman

Reed²,

Burwen³

et al. 2005

The Journal of Pediatrics

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mentioning

confidence: 99%

Transient Bulging Fontanelle after Vaccination: Case Report and Review of the Vaccine Adverse Event Reporting System

Freedman

Reed²,

Burwen³

et al. 2005

The Journal of Pediatrics

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“…O abaulamento de fontanela como uma das implicações neurológicas do oferecimento da vitamina A junto com vacina é registrado por West et al (1992), DiFrancisco et al (1993) e Agoestina et al (1994), embora Stabell et al (1995) não o identificassem em crianças de seis a nove meses de idade que receberam, respectivamente, 100.000 e 200.000 UI de vitamina A associada à vacina anti-sarampo. É conhecido, já há algumas décadas, que tanto o excesso de vitamina A quanto o componente pertussis da DPT são responsáveis por complicações neurológicas em crianças (Ström, 1967;Jacob, 1979).…”

Section: Discussionunclassified

Tolerância à aplicação de megadoses de vitamina A associada à vacinação em crianças no Nordeste do Brasil

et al. 2000

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A follow-up study was carried out in two localities in the semi-arid region of the State of Bahia, Northeast Brazil, with the aim of identifying the occurrence and nature of possible acute side effects subsequent to vitamin A megadose supplement given together with mass immunization in children 6-59 months old. The sample consisted of 852 children, 416 from the county of Teofilandia who received vitamin A together with vaccines and 436 from Santa Barbara, who received only vaccine. In the 24 hours before immunization, children from both groups had similar incidences of diarrhea, fever, and vomiting. Anorexia was more prevalent in Teofilandia and remained so throughout the study period. The results suggest that acute side effects like diarrhea, vomiting, fever, or anorexia were not associated with the vitamin A dosage given with mass OPV, DPT, and measles immunization.

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“…Our hypothesis is that vaccination-associated adverse effects in young children are due to liver damage and vitamin A intoxication. For instance, vomiting and bulging fontanelles due to increased intracranial pressure are symptoms of hypervitaminosis A [ 91 ] and are often reported following vaccination [ 92 , 93 , 94 ]. Features of autism spectrum disorder (ASD) also resemble those of acute and chronic hypervitaminosis A.…”

Section: Vitamin a And Immune Functionmentioning

confidence: 99%

Multiple Vaccinations and the Enigma of Vaccine Injury

Mawson

Croft

2020

Vaccines

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A growing number of vaccines are administered at the same time or in close succession, increasing the complexity of assessing vaccine safety. Individual vaccines are assumed to have no other effect than protection against the targeted pathogen, but vaccines also have nonspecific and interactive effects, the outcomes of which can be beneficial or harmful. To date, no controlled trials and very few observational studies have determined the impact of vaccination schedules on overall health. The balance of the risks and benefits from mass vaccination therefore remains uncertain. Recent studies worryingly suggest links between multiple vaccinations and increased risks of diverse multisystem health problems, including allergies, infections, and neuropsychiatric or neurodevelopmental disorders. Here, we propose that, in susceptible persons, multiple vaccinations activate the retinoid cascade and trigger apoptotic hepatitis, leading to cholestatic liver dysfunction, in which stored vitamin A compounds (retinyl esters and retinoic acid) enter the circulation in toxic concentrations; this induces endogenous forms of hypervitaminosis A, with the severity of adverse outcomes being directly proportional to the concentration of circulating retinoids. In very low concentrations, vitamin A and its major metabolite retinoic acid contribute to immune function and to the process of immunization, whereas excess vitamin A increases the risk of adverse events, including common “side-effects” as well as chronic adverse outcomes. The increasing rates of allergy, ear infections, and neurodevelopmental disorders (NDDs) in countries with high rates of vaccination could be related to mass vaccination and to its impact on liver function and vitamin A metabolism, collectively representing endogenous manifestations of hypervitaminosis A. Further studies of health outcomes in vaccinated and unvaccinated groups are urgently needed, to increase understanding of the pathophysiology and treatment of vaccine injury, to identify the risk factors and screen for vaccine injury, to inform public health policy on potential hazards related to vaccination schedules, and to optimize the safety and benefits of vaccines.

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Increased Intracranial Pressure After Diphtheria, Tetanus, and Pertussis Immunization

Cited by 5 publications

References 4 publications

Transient Bulging Fontanelle after Vaccination: Case Report and Review of the Vaccine Adverse Event Reporting System

Transient Bulging Fontanelle after Vaccination: Case Report and Review of the Vaccine Adverse Event Reporting System

Tolerância à aplicação de megadoses de vitamina A associada à vacinação em crianças no Nordeste do Brasil

Multiple Vaccinations and the Enigma of Vaccine Injury

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