Increased intraplacental antifibrinolytic activity in toxemia: Relation to morphological and biochemical findings

Kanfer, A; Bruch, Joachim; Fondacci, Clarisse; He, Chaoqi; Nguyen, Geneviève; Delarue, F; Nessmann, C; Uzan, S.

doi:10.1016/s0143-4004(05)80535-1

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The fibrinoid tissue we observed with IHC is most probably of fibrin-type fibrinoid, derived from the coagulation cascade. Fibrin-type fibrinoid is more prevalent in PE placentas [347], and is associated with apoptosis in trophoblast cells in PE [348]. In cultured primary term trophoblasts fibrin protects against hypoxic injury [349].…”

Section: Fibrinoid Tissuementioning

confidence: 99%

Long-chain Polyunsaturated Fatty Acid Transport across Human Placental Choriocarcinoma (BeWo) Cells

et al. 2009

View full text Add to dashboard Cite

Section: Fibrinoid Tissuementioning

confidence: 99%

Long-chain Polyunsaturated Fatty Acid Transport across Human Placental Choriocarcinoma (BeWo) Cells

et al. 2009

View full text Add to dashboard Cite

“…A hypercoagulable state is developed during the third trimester of normal pregnancies to minimize bleeding at delivery and during postpartum, which is a significant cause of maternal mortality [7]. This protective hypercoagulable state is exaggerated in preeclampsia patients to become a prothrombotic state associated with intravascular coagulation, microvascular thrombosis, and the impairment of utero-placental circulation [8]. The underlying mechanism remains poorly understood regarding how the protective hypercoagulable state becomes the detrimental prothrombotic state or thrombosis in preeclampsia patients.…”

Section: Introductionmentioning

confidence: 99%

Prothrombotic state associated with preeclampsia

Han

Chen

Dong

2021

Current Opinion in Hematology

View full text Add to dashboard Cite

Purpose of review Preeclampsia is a common complication of pregnancy and contributes significantly to maternal and fetal morbidity and mortality. A protective hypercoagulable state is often developed during late pregnancy and can evolve into a prothrombotic state in patients with preeclampsia. The underlying mechanism of this prothrombotic transition remains poorly understood. We discuss recent progress in understanding the pathophysiology of preeclampsia and associated prothrombotic state. Recent findings The hypercoagulable state developed during pregnancy is initiated by placental factors and progresses into the prothrombotic state in preeclampsia when the placenta is subjected ischemic and oxidative injuries. The cause of the preeclampsia-induced prothrombotic state is multifactorial, involving not only placental factors but also maternal conditions, which include genetic predisposition, preexisting medical conditions, and conditions acquired during pregnancy. Endotheliopathy is the primary pathology of preeclampsia and contributes to the prothrombotic state by inducing the dysregulation of coagulation, platelets, and adhesive ligands. Summary Patients with preeclampsia often develop a severe prothrombotic state that predisposes them to life-threatening thrombosis and thromboembolism during and after pregnancy. Early recognition and treatment of this prothrombotic state can improve maternal and infant outcomes of preeclampsia patients.

show abstract

Increased intraplacental antifibrinolytic activity in toxemia: Relation to morphological and biochemical findings

Cited by 2 publications

References 0 publications

Long-chain Polyunsaturated Fatty Acid Transport across Human Placental Choriocarcinoma (BeWo) Cells

Long-chain Polyunsaturated Fatty Acid Transport across Human Placental Choriocarcinoma (BeWo) Cells

Prothrombotic state associated with preeclampsia

Contact Info

Product

Resources

About