Increased intrathecal TGF-β1, but not IL-12, IFN-γ and IL-10 levels in Alzheimer’s disease patients

Rota, Eugenia; Bellone, Graziella; Rocca, Paola; Bergamasco, B.; Emanuelli, G; Ferrero, P.

doi:10.1007/s10072-006-0562-6

Cited by 113 publications

(87 citation statements)

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“…These plaque-associated microglia expressed strongly TGF-␤1 and TGF-␤1 receptor-R1 and -R2 transcripts, which were increased in the brain of APP Swe /PS1/CCR2 Ϫ/Ϫ mice. Enhanced TGF-␤1 levels have already been described in AD patients (van der Wal et al, 1993; Wyss-Coray et al, 1997; Rota et al, 2006) and in our mouse model of AD (Richard et al, 2008). Although the role of TGF-␤1 in AD pathology remains controversial, this cytokine binds A␤ with high affinity and enhances its oligomerization in vitro (Mousseau et al, 2003).…”

Section: App Swe /Ps1/ccr2supporting

confidence: 57%

CC Chemokine Receptor 2 Deficiency Aggravates Cognitive Impairments and Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

Naert¹,

Rivest²

2011

J. Neurosci.

164

125

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Circulating monocytoid cells have the ability to infiltrate nervous tissue, differentiate into microglia, and clear amyloid-␤ (A␤) from the brain of mouse models of Alzheimer's disease. Interaction between the chemokine CCL2 and its CC chemokine receptor 2 (CCR2) plays a critical role in the recruitment of inflammatory monocytes into the injured/diseased brain. Here, we show that CCR2 deficiency aggravates mnesic deficits and amyloid pathology in transgenic mice expressing the chimeric mouse/human ␤-amyloid precursor protein and presenilin 1 (APP Swe /PS1). Indeed, memory impairment was accelerated and enhanced in APP Swe /PS1/CCR2 Ϫ/Ϫ mice. Apparition of cognitive decline occurred earlier (i.e., at 3 months of age before plaque formation) and correlated with intracellular accumulation of soluble oligomeric forms of A␤. Memory deficits worsened with age and were aggravated in APP Swe /PS1/CCR2 Ϫ/Ϫ mice compared with their respective control groups. Soluble A␤ assemblies increased significantly in APP Swe /PS1 mice in a context of CCR2 deficiency, whereas the plaque load remained relatively similar in the brain of aging APP Swe /PS1 and APP Swe /PS1/CCR2 Ϫ/Ϫ mice. However, CCR2 deficiency stimulated the expression of TGF-␤1, TGF-␤ receptors, and CX 3 CR1 transcripts in plaque-associated microglia, a pattern that is characteristic of an antiinflammatory subset of myeloid cells. A decreased expression of CCR2 could play a potential role in the etiology of Alzheimer's disease, a neurodegenerative pathology that could be treated by a genetic upregulation of the transgene in monocytoid cells.

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Section: App Swe /Ps1/ccr2supporting

confidence: 57%

CC Chemokine Receptor 2 Deficiency Aggravates Cognitive Impairments and Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

Naert¹,

Rivest²

2011

J. Neurosci.

164

125

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“…In view of the data of the current work, rotenone administration for 14 d in ovariectomized rats elevated the level of serum TGF-β1 and MCP-1 significantly. This finding is greatly supported by those of Rota et al [42] and…”

Section: Discussionsupporting

confidence: 82%

Updates in the pathophysiological mechanisms of Parkinson’s disease: Emerging role of bone marrow mesenchymal stem cells

Ahmed¹,

Salem²,

Atta³

et al. 2016

WJSC

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“…However, the CSF levels of IL-10 in patients with neuro-Behçet disease, MS (17), tuberculous meningitis (18), Alzheimer's disease (19) and migraine headache (20) are known to show no elevation.…”

Section: Discussionmentioning

confidence: 99%

Interleukin 10 Level in the Cerebrospinal Fluid as a Possible Biomarker for Lymphomatosis Cerebri

et al. 2015

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A 71-year-old immunocompetent man developed cognitive decline and gait disturbance. Brain magnetic resonance imaging (MRI) revealed bilateral diffuse leukoencephalopathy without a mass lesion. An analysis of the cerebrospinal fluid (CSF) showed elevated levels of interleukin (IL)-10. The condition of the patient progressively deteriorated, and intravenous high-dose steroids proved ineffective. Detection of nondestructive, diffusely infiltrating, large B-cell lymphoma in biopsy and autopsy specimens led to a diagnosis of lymphomatosis cerebri (LC). On serial MRI, the basal ganglia and white matter lesions increased in parallel with the levels of IL-10. These findings suggest that the IL-10 level in the CSF may represent a potentially useful biomarker for the early diagnosis and monitoring of the disease progression in LC.

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Increased intrathecal TGF-β1, but not IL-12, IFN-γ and IL-10 levels in Alzheimer’s disease patients

Cited by 113 publications

References 0 publications

CC Chemokine Receptor 2 Deficiency Aggravates Cognitive Impairments and Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

CC Chemokine Receptor 2 Deficiency Aggravates Cognitive Impairments and Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

Updates in the pathophysiological mechanisms of Parkinson’s disease: Emerging role of bone marrow mesenchymal stem cells

Interleukin 10 Level in the Cerebrospinal Fluid as a Possible Biomarker for Lymphomatosis Cerebri

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