Increased killer cell activity in aged humans

Bátory, Gabriella; Benczúr, M.; Varga, M; Garam, T; Ónody, Clara; Petrányi, G

doi:10.1016/s0171-2985(81)80010-1

Cited by 31 publications

(4 citation statements)

References 23 publications

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“…Besides unknown factors that may influence the immune system, variation in NK activities has been shown to be due to age (17), pregnancy (18), administration of prostaglandins (19)(20)(21), cytokines (20)(21)(22) and drugs (1,2), and to viral infections (23). In this study, normal subjects and patients with thyroid disease were carefully age-and sex-matched, and individuals known to be pregnant or taking steroids were excluded from the study.…”

Section: Discussionmentioning

confidence: 99%

Natural Killer Cell Activity in Patients with Graves' Disease and Hashimoto's Thyroiditis

Wenzel¹,

Chow²,

Baur³

et al. 1998

Thyroid

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Natural killer (NK) cell activity of peripheral blood lymphocytes (PBL) against k562 human tumor cell targets was studied in patients with Graves' disease and Hashimoto's thyroiditis. NK activity was measured in a standard 4-hour 51chromium (Cr) release assay. Cytotoxicity was expressed as lytic units (LU)/10(6) PBL. Significantly decreased NK cell activity was demonstrated in both groups of patients, with mean (+/- SE) lytic units of 10.3 (+/- 9.1) and 13.3 (+/- 10.3) for patients with Graves' disease and Hashimoto's thyroiditis, respectively, compared with 36.0 (+/- 26.3) for age- and sex-matched normal subjects. When patients with Graves' disease were analyzed according to their thyroid status; NK activity was significantly depressed in (1) hyperthyroid patients before treatment; (2) hyperthyroid patients receiving antithyroid therapy; and (3) euthyroid patients receiving antithyroid therapy, compared with normal subjects. Graves' disease patients who were hypothyroid after radioactive iodine therapy or thyroidectomy had normal NK activity. No significant differences between hyperthyroid and euthyroid patients or between hypothyroid patients and normal subjects were demonstrated. NK activity in patients with Graves' disease did not correlate with serum levels of thyroxine, the presence or severity of ophthalmopathy, or titers of serum thyroid antibodies. In patients with Hashimoto's thyroiditis there was no correlation between NK activity and goiter size, titers of antithyroid antibodies, or thyroid status. These findings suggest that depression of NK activity in both disorders is secondary to abnormalities of thyroid hormone secretion, although an effect of the underlying autoimmune reactions has not been excluded.

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Section: Discussionmentioning

confidence: 99%

Natural Killer Cell Activity in Patients with Graves' Disease and Hashimoto's Thyroiditis

Wenzel¹,

Chow²,

Baur³

et al. 1998

Thyroid

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“…When looking at NK cell number and activity in the spleen from both mice and rats, there is a clear and consistent age-associated decline in NK cell number and activity (Weindruch et al 1983;Saxena et al 1984;Nasrullah & Mazzeo, 1992). However, when examining peripheral-blood NK cell activity in human subjects, it is frequently reported that no age-associated change is found (Ligthart et al 1986;Murasko et al 1986;Ferguson et al 1995), and in some cases increases in NK cell number and activity have been observed (Batory et al 1981;Krishnaraj & Blandford, 1987Sansoni et al 1993;Xu et al 1993). The findings from one study (Facchini et al 1987) indicate that the activity of NK cells (expressed per cell basis) decreases with age.…”

Section: Ageing and Immune Functionmentioning

confidence: 98%

Exercise and immune function: effect of ageing and nutrition

et al. 1999

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fax +45 3545 6648, email bkp@rh.dk Strenuous exercise is followed by lymphopenia, neutrophilia, impaired natural immunity, decreased lymphocyte proliferative responses to mitogens, a low level of secretory immunoglobulin A in saliva, but high circulating levels of pro-and anti-inflammatory cytokines. These exercise-induced immune changes may provide the physiological basis of altered resistance to infections. The mechanisms underlying exercise-induced immune changes are multifactorial and include neuroendocrinological and metabolic mechanisms. Nutritional supplementation with glutamine abolishes the exercise-induced decline in plasma glutamine, but does not influence post-exercise immune impairment. However, carbohydrate loading diminishes most exercise effects of cytokines, lymphocyte and neutrophils. The diminished neutrophilia and elastase (EC 3.4.21.37) responses to eccentric exercise in elderly subjects were enhanced to levels comparable with those of young subjects by fish oil or vitamin E supplements. However, although vitamin C supplementation may diminish the risk of contracting an infection after strenuous exercise, it is not obvious that this effect is linked to an effect of vitamin C on exercise-induced immune changes. In conclusion, it is premature to make recommendations regarding nutritional supplementation to avoid post-exercise impairment of the immune system.

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“…However, a significant age‐dependent decline in 18 hr ADCC as well as monocyte‐mediated spontaneous cytotoxic activity was found in controls but not in patients. Results from other studies on this subject vary 31, 32, 33…”

Section: Discussionmentioning

confidence: 77%

Natural killer (NK) cell function is a strong prognostic factor in colorectal carcinoma patients treated with the monoclonal antibody 17‐1A

Liljefors

Nilsson

Skog

et al. 2003

Intl Journal of Cancer

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Tumor cells might be susceptible to different effector functions of the immune system. This cytotoxic capacity has been utilized to analyze the prognostic significance of peripheral blood mononuclear cells (PBMC) in patients with metastatic colorectal carcinoma (CRC) treated with the monoclonal antibody (MAb)17-1A. Such analysis might form the basis for future patient selection and may lead to improvements in therapeutic strategies. Between 1986 and 1998, 73 patients were treated with regimens containing MAb17-1A. Prior to therapy, the lytic capability of PBMC was assayed against: K562 (4 hr assay), the CRC cell line SW948 (4 hr and 18 hr assays) and antibody-dependent cellular cytotoxicity (ADCC, 18 hr assay). Since the study was performed over 13 years, the assays were checked for time-related bias. Reproducibility over time was satisfactory. Patients exhibited a significantly higher cytotoxic capability in all 4 assays compared to healthy control donors. No correlation to clinical outcome was noted for 18 hr ADCC and 18 hr spontaneous cytotoxicity. Pretreatment natural killer (NK) cell cytotoxicity (K562) was significantly related to overall survival (OS), progression-free survival (PFS), and response rate. OS for patients with high and low NK cell cytotoxicity was 71 vs. 30 weeks, respectively (p ‫؍‬ 0.007). NK cell cytotoxicity (K562) was an independent prognostic factor for OS (p ‫؍‬ 0.016). Pretreatment NK cell activity is a strong prognostic factor for patients with metastatic CRC receiving MAb17-1A therapy and is a predictor for OS, PFS and response. These results should be considered when designing antibody-based therapeutic protocols.

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Increased killer cell activity in aged humans

Cited by 31 publications

References 23 publications

Natural Killer Cell Activity in Patients with Graves' Disease and Hashimoto's Thyroiditis

Natural Killer Cell Activity in Patients with Graves' Disease and Hashimoto's Thyroiditis

Exercise and immune function: effect of ageing and nutrition

Natural killer (NK) cell function is a strong prognostic factor in colorectal carcinoma patients treated with the monoclonal antibody 17‐1A

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