Increased late preterm birth risk and altered uterine blood flow upon exposure to heat stress

Yüzen, Dennis; Graf, Isabel; Tallarek, Ann‐Christin; Hollwitz, Bettina; Wiessner, Christian; Schleußner, E; Stammer, Detlef; Padula, Amy; Hecher, Kurt; Arck, Petra C.; Diemert, Anke

doi:10.1016/j.ebiom.2023.104651

Cited by 15 publications

(3 citation statements)

References 71 publications

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“…Prenatal stress has been associated with various birth complications, including preterm labour, preterm delivery, low birth weight, shortened gestational length, and a range of long-term effects such as attachment difficulties, stress hyper-responsiveness, cardio-metabolic and neurological disorders, asthma, allergies, difficult temperament, and affective disorders ( 2 , 22 , 23 ).…”

Section: Connections Between Prenatal Stress and Adverse Neonatal And...mentioning

confidence: 99%

Controlling fetal stress for preventing adverse health conditions in neonates and children

Calcaterra,

Zuccotti,

Pelizzo

2024

Front. Pain Res.

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Section: Connections Between Prenatal Stress and Adverse Neonatal And...mentioning

confidence: 99%

Controlling fetal stress for preventing adverse health conditions in neonates and children

Calcaterra,

Zuccotti,

Pelizzo

2024

Front. Pain Res.

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“…Although few studies directly address physiological mechanisms, there are several biologically plausible pathways. Heat stress and dehydration reduce uterine and placental blood flow, possibly affecting uterine contractility and/or hormone levels governing the induction of labor . Heat stress causes oxidative stress and the release of heat shock proteins that may trigger an inflammatory cascade, plausibly affecting the induction of labor .…”

Section: Introductionmentioning

confidence: 99%

“…Heat stress and dehydration reduce uterine and placental blood flow, possibly affecting uterine contractility and/or hormone levels governing the induction of labor. 17 , 18 Heat stress causes oxidative stress and the release of heat shock proteins that may trigger an inflammatory cascade, plausibly affecting the induction of labor. 18 , 19 Extreme heat may also trigger the premature rupture of membranes, 20 leading to labor (spontaneous or medically induced); alternatively, it may motivate a medically indicated delivery by exacerbating maternal morbidities (eg, hypertension) or fetal distress.…”

Section: Introductionmentioning

confidence: 99%

Preterm and Early-Term Delivery After Heat Waves in 50 US Metropolitan Areas

Darrow,

Huang,

Warren

et al. 2024

JAMA Netw Open

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ImportanceHeat waves are increasing in frequency, intensity, and duration and may be acutely associated with pregnancy outcomes.ObjectiveTo examine changes in daily rates of preterm and early-term birth after heat waves in a 25-year nationwide study.Design, Setting, and ParticipantsThis cohort study of singleton births used birth records from 1993 to 2017 from the 50 most populous US metropolitan statistical areas (MSAs). The study included 53 million births, covering 52.8% of US births over the period. Data were analyzed between October 2022 and March 2023 at the National Center for Health Statistics.ExposuresDaily temperature data from Daymet at 1-km2 resolution were averaged over each MSA using population weighting. Heat waves were defined in the 4 days (lag, 0-3 days) or 7 days (lag, 0-6 days) preceding birth.Main Outcomes and MeasuresDaily counts of preterm birth (28 to &lt;37 weeks), early-term birth (37 to &lt;39 weeks), and ongoing pregnancies in each gestational week on each day were enumerated in each MSA. Rate ratios for heat wave metrics were obtained from time-series models restricted to the warm season (May to September) adjusting for MSA, year, day of season, and day of week, and offset by pregnancies at risk.ResultsThere were 53 154 816 eligible births in the 50 MSAs from 1993 to 2017; 2 153 609 preterm births and 5 795 313 early-term births occurring in the warm season were analyzed. A total of 30.0% of mothers were younger than 25 years, 53.8% were 25 to 34 years, and 16.3% were 35 years or older. Heat waves were positively associated with daily rates of preterm and early-term births, showing a dose-response association with heat wave duration and temperatures and stronger associations in the more acute 4-day window. After 4 consecutive days of mean temperatures exceeding the local 97.5th percentile, the rate ratio for preterm birth was 1.02 (95% CI, 1.00-1.03), and the rate ratio for early-term birth was 1.01 (95% CI, 1.01-1.02). For the same exposure, among those who were 29 years of age or younger, had a high school education or less, and belonged to a racial or ethnic minority group, the rate ratios were 1.04 (95% CI, 1.02-1.06) for preterm birth and 1.03 (95% CI, 1.02-1.05) for early-term birth. Results were robust to alternative heat wave definitions, excluding medically induced deliveries, and alternative statistical model specifications.Conclusions and RelevanceIn this cohort study, preterm and early-term birth rates increased after heat waves, particularly among socioeconomically disadvantaged subgroups. Extreme heat events have implications for perinatal health.

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Hitzeaktionspläne in Einrichtungen der Krankenversorgung und Pflege

Niebuhr,

Grewe

2024

Gesundheit Und Nachhaltigkeit

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Increased late preterm birth risk and altered uterine blood flow upon exposure to heat stress

Cited by 15 publications

References 71 publications

Controlling fetal stress for preventing adverse health conditions in neonates and children

Controlling fetal stress for preventing adverse health conditions in neonates and children

Preterm and Early-Term Delivery After Heat Waves in 50 US Metropolitan Areas

Hitzeaktionspläne in Einrichtungen der Krankenversorgung und Pflege

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