Increased level of cAMP in the rat intestinal musosa caused by sodium lauryl sulphate

Briseid, Gudrun; I, Oye; Briseid, Kjell

doi:10.1007/bf00500898

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…In the present work, these two possibilities have been explored by studying the influence of theophylline and DOSS on the abovementioned absorption processes in vivo. Another anionic surfactant, dodecylsulphate (=DDS), was also included, since this drug may induce some increased formation of CAMP (Briseid et al 1976(Briseid et al & 1977Sund & Hillestad 1981). A short account of this study has been presented elsewhere (Sund & Olsen 1978).…”

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confidence: 99%

Net Sodium and Glucose Transport in the Jejunum, Ileum and Colon of Anaesthetized Rats in Response to Intraluminal Theophylline and Anionic Surfactants

Sund

Olsen

1981

Acta Pharmacologica et Toxicologica

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Osmotically balanced solutions of sodium chloride and glucose (5-150 mmol/l) were instilled into rats prepared with two tied intestinal loops (jej-col or il-col). Luminal accumulation or disappearance of Na and glucose after 15 min. was determined, and the parameters of the linear regression lines of net Na flux (y) with initial Na concentration (x) calculated. Control cation and glucose transport were changed by dioctylsulphosuccinate and dodecylsulphate in the way described by Sund & Matheson (1978). Theophylline (10-25 mmol/l) on the other hand did not alter glucose disappearance, and had a distinctly dissimilar effect onnet Na transport compared to the surfactants. This could be described as aparallel displacement ofthe control regression lines to the right, without improvement in correlation. This effect of theophylline was greatest in the ileum, where mean luminal Na concentration corresponding to zero net transport was raised from about 70 mmol/l under control condition to values above 200 mmol/l. The results are consistent with the view that theophylline mainly affects transcellular and the surfactants mainly paracellular sodium transport, and do not support the theory that the effect of dioctylsulphosuccinate on intestinal transport is related to an activation of the mucosal adenylate cyclase/cAMP system, at least not in short term experiments.

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confidence: 99%

Net Sodium and Glucose Transport in the Jejunum, Ileum and Colon of Anaesthetized Rats in Response to Intraluminal Theophylline and Anionic Surfactants

Sund

Olsen

1981

Acta Pharmacologica et Toxicologica

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confidence: 99%

On the Inducibility of Cytosolic and Microsomal Carboxylesterase by Phenobarbital in Rat Tissues

Nousiainen

Hänninen

1981

Acta Pharmacologica et Toxicologica

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“…During the last decade it has been shown that the potent hydragogue toxin from Vibrio cholera causes stimulation of the mucosal adenylate cyclase/cAMP system; this in turn leads t o luminal water and electrolyte accumulation probably by stimulation of cellular anion efflux or inhibition of coupled sodium-anion influx. The question has been raised if also hydragogue drugs may act o n this system, and research along this line has been stimulated Briseid et al 1976Briseid et al & 1977Conley et al 1976a & b;Coyne et al 1976Coyne et al & 1977Donowitz & Binder 1975;Gaginella et ai. 1978;Loeschke 1979;Simon et al 1978;S i m o n & Kather 1980;S u n d & Hillestad 1978), with different results a s t o the significance of t h e system f o r t h e hydragogue effects.…”

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confidence: 99%

Studies on Hydragogue Drugs: Effect of Surfactants on cAMP Levels in the Rat Jejunal Mucosa in Short Time Experiments in Vivo

Sund

Hillestad

1981

Acta Pharmacologica et Toxicologica

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Theophylline and the surface active agents specified below were instilled into the jejunum of anaesthetized rats, and the cAMP levels in the mucosal tissue determined after 7 1/2 and 15 min. incubation in vivo. Most experiments were done in rats prepared with two tied intestinal loops; one of these served as the control loop and the other as the stimulated loop. The surfactants (mmol/l) included dodecylsulphate (17), dioctylsulphosuccinate (5.6), cetrimonium bromide (4.1), deoxycholic acid (2.4 and 3.6) and Lubrol WX (0.5% w/v). Theophylline (10 mmol/l) caused a substantial increase in cAMP (110%±17, n=7 and 60%±8.9, n=10, respectively) and dodecylsulphate a minor and transitory increase (28.1%±3.8, n=10 and 11.7%±4.9, n=8). The other agents were without stimulatory effect on cAMP, allthough like dodecylsulphate they may significantly affect normal intestinal cation and glucose transport under these conditions. The results, therefore, do not suggest that stimulation of cAMP and intestinal secretion induced thereby is any significant phenomenon in the overall hydragogue effect of these agents, at least not in short term jejunal experiments.

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Increased level of cAMP in the rat intestinal musosa caused by sodium lauryl sulphate

Cited by 7 publications

References 15 publications

Net Sodium and Glucose Transport in the Jejunum, Ileum and Colon of Anaesthetized Rats in Response to Intraluminal Theophylline and Anionic Surfactants

Net Sodium and Glucose Transport in the Jejunum, Ileum and Colon of Anaesthetized Rats in Response to Intraluminal Theophylline and Anionic Surfactants

On the Inducibility of Cytosolic and Microsomal Carboxylesterase by Phenobarbital in Rat Tissues

Studies on Hydragogue Drugs: Effect of Surfactants on cAMP Levels in the Rat Jejunal Mucosa in Short Time Experiments in Vivo

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