Increased level of cardiorespiratory fitness blunts the inflammatory response in metabolic syndrome

Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training

“…For instance, greater white blood cell count is noted in subjects with MS factors and low CRF (517). In another example, Pitsavos et al (505) noted that after controlling for various potential confounders, physically active individuals with MS had lower levels of CRP, white blood cells, serum amyloid A, TNFα, and IL-6 when compared to sedentary subjects.…”

Does Good Aerobic Capacity Attenuate the Effects of Aging on Cardiovascular Risk Factors? Results from a Cross-Sectional Study in a Latino Population

“…In 2007, Anderssen and colleagues reported that school children aged 9 to 15 with low aerobic capacity had the highest clustering of CVD risk factors (total-C : HDL-C ratio, high plasma triglycerides, sum of 4 skin folds, and SBP) [13]. Another study showed that increased cardiorespiratory fitness (>13 METs) in adult men with the metabolic syndrome was associated with beneficial effects on inflammation [14]. This report also demonstrated that exercise improved insulin resistance, dyslipidemia, hypertension, and platelet function in this cohort [14].…”

“…Another study showed that increased cardiorespiratory fitness (>13 METs) in adult men with the metabolic syndrome was associated with beneficial effects on inflammation [14]. This report also demonstrated that exercise improved insulin resistance, dyslipidemia, hypertension, and platelet function in this cohort [14]. Similar findings were reported by Mora and colleagues in 2007: regular physical activity in a group of 27,055 healthy women was associated with moderate reductions in C-reactive protein, soluble intracellular adhesion molecule-1, and vascular adhesion molecules [15].…”

The impact of cardiorespiratory fitness on inflammatory markers in patients with metabolic syndrome

“…They have shown a strong inverse trent toward decreasing CRP levels with increasing fitness quartiles in subjects without metabolic abnormalities, subjects with one or two metabolic abnormalities and subjects with the metabolic syndrome. In contrary, Rana et al [5] have not reported such a significant association in patients without metabolic syndrome. The use of different biomarkers to measure the status of inflammation may partially explain this difference.…”

“…Recently, I read the article with a great interest reported by Rana et al and published in International Journal of Cardiology [5]. In their study, they have investigated another aspect of this subject that is the impact of cardiorespiratory fitness on inflammatory response in patients with metabolic syndrome.…”