Increased level of YKL-40 in sera from patients with early rheumatoid arthritis: a new marker for disease activity

Peltomaa, Ritva; Paimela, Leena; Harvey, Sheryl; Helve, T; Leirisalo‐Repo, Marjatta

doi:10.1007/s002960100115

Cited by 57 publications

(51 citation statements)

References 14 publications

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“…Furthermore, the serum fibrosis markers tested are produced in multiple tissues throughout the body which can lead to spurious elevations. For example, serum HA and YKL-40 levels increase in subjects with active rheumatological conditions and in subjects with renal insufficiency 39 ; however, both conditions were rare in our population. Moreover, the serum markers evaluated, which reflect active fibrogenesis and/ or fibrolysis rather than the static amount of collagen or scar that has accumulated in the liver, are not as good at estimating disease stage.…”

Section: Discussionmentioning

confidence: 59%

Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis C

Fontana¹,

Goodman²,

Dienstag³

et al. 2008

Hepatology

165

117

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This study determined the utility of a panel of serum fibrosis markers along with routine laboratory tests in estimating the likelihood of histological cirrhosis in a cohort of prior nonresponders with chronic hepatitis C. The relationship between serum markers and quantitative hepatic collagen content was also determined. Liver biopsy samples from 513 subjects enrolled in the HALT-C trial were assigned Ishak fibrosis scores. The collagen content of 386 sirius-red stained, nonfragmented biopsy samples was quantified using computerized morphometry. Serum tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), amino-terminal peptide of type III procollagen (PIIINP), hyaluronic acid (HA), and YKL-40 levels were determined using commercially available assays.Sixty-two percent of patients had noncirrhotic fibrosis (Ishak stage 2-4) whereas 38% had cirrhosis (

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Section: Discussionmentioning

confidence: 59%

Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis C

Fontana¹,

Goodman²,

Dienstag³

et al. 2008

Hepatology

165

117

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“…These typically reflect different aspects of both synthesis and degradation of matrix components and include markers of bone formation and resorption, cartilage turnover and/or degradation, and synovial hyperplasia and/or inflammation. Examples include serum cartilage oligomeric matrix protein (COMP) (13), human cartilage gp-39 (YKL-40) (14), which reflects cartilage remodeling and synovial hyperplasia, and serum matrix metalloproteinase 3 (MMP-3) (15,16), which primarily reflects synovial inflammation. Other categories of biomarkers shown to independently predict joint damage in patients with RA include cytokines that regulate the process of osteoclast activation, such as RANKL and soluble osteoprotegerin (OPG) (17).…”

mentioning

confidence: 99%

Serum matrix metalloproteinase 3 is an independent predictor of structural damage progression in patients with ankylosing spondylitis

Maksymowych¹,

Landewé²,

Conner‐Spady³

et al. 2007

Arthritis & Rheumatism

154

100

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Objective. In prospective studies, only baseline radiographic damage has been identified as an independent predictor of radiographic progression in ankylosing spondylitis (AS). Several biomarkers have been identified as independent predictors of radiographic progression in rheumatoid arthritis, however, and these may be of use in AS. This study was undertaken to analyze serologic biomarkers as predictors of radiographic progression in AS.Methods. We measured a panel of biomarkers reflecting cartilage turnover and osteoclasis. These biomarkers were cartilage oligomeric matrix protein, human cartilage gp-39 (YKL-40), type II collagen epitopes detected by the C2C and C1,2C degradation assays and the CPII synthesis assay, aggrecan 846 epitope, osteoprotegerin, and matrix metalloproteinase 3 (MMP-3). The analysis was performed in a cohort of AS patients from the Netherlands, Belgium, and France enrolled in a longitudinal study, the Outcome Assessments in Ankylosing Spondylitis International Study. We examined 2-year radiographic progression data scored using the modified Stoke AS Spine Score (mSASSS).Results. Complete data were available on 97 patients. Only the biomarkers YKL-40 and MMP-3 showed weak to moderate univariate correlation with 2-year progression. After adjustment for sex, age, disease duration, C-reactive protein level, and baseline mSASSS, only MMP-3 was significantly associated with 2-year progression (␤ ‫؍‬ 0.29, P ‫؍‬ 0.004). Logistic regression analysis revealed MMP-3 (cutoff 68 ng/ml; odds ratio 9.4 [95% confidence interval 1.6-56]) and baseline mSASSS (cutoff 10 mSASSS units; odds ratio 18.6 [95% confidence interval 2.5-138]) as the only independent predictors of 2-year progression (cutoff 3 mSASSS units; model R 2 ‫؍‬ 50%). MMP-3 was primarily contributory in patients who already had substantial baseline damage (>10 mSASSS units).Conclusion. These results indicate that MMP-3 is a significant independent predictor of radiographic progression in patients with AS, particularly in those with preexisting radiographic damage.Ankylosing spondylitis (AS) is characterized by the presence of inflammation in the spine and the development of ankylosis in the facet joints and intervertebral discs, which leads to immobility and functional impairment. The degree and rate of progression of radiographic changes can be reliably assessed using a validated scoring method, the modified Stoke AS Spine Score (mSASSS), which records structural changes in

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“…On the basis of correlation studies between serum and synovial fluid concentrations of YKL-40, serum YKL-40 might reflect articular cartilage degradation and the degree of synovial inflammation in RA (32). In this regard, serum YKL-40 levels increase even in early RA patients (22,33). In a recent study, it has been proposed that a »multi-biomarker disease activity score« which was calculated using the concentrations of twelve biomarkers, including YKL-40, measured disease activity (34,35).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, in terms of the disease prediction, CHIT was superior to YKL-40. Previously, serum YKL-40 levels were determined to assess its usefulness as a marker in RA pathogenesis (22,28). However, serum CHIT activity was not evaluated in any RA cohort and, to our knowledge, this is the first study in the literature to present elevated CHIT acti vities in patients with RA.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, in normal human cartilage there was no expression of YKL-40. Later, several studies specified that not only synovial YKL-40 levels, but also serum levels were found correlated with the disease activity (22,23). Although CHIT activity in serum was evaluated in several inflammatory diseases, besides lysosomal storage diseases, there is only one study which evaluated the activity of CHIT in the context of rheumatologic disease.…”

Section: Introductionmentioning

confidence: 99%

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Increased Chitotriosidase Activities in Patients with Rheumatoid Arthritis: A Possible Novel Marker?

Başok¹,

Kuçur²,

Kızılgül³

et al. 2014

Journal of Medical Biochemistry

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SummaryBackground: Chitotriosidase and YKL-40 are well-known in humans as Glyco_18 domain-containing proteins that are the common feature of mammalian chitinases and chitinaselike proteins. Previously, increased levels of YKL-40 were found correlated with the disease activity of rheumatoid arthritis. However, serum chitotriosidase activity in rheumatoid arthritis is not known yet. The aim of this study was to determine YKL-40 and chitotriosidase in patients with rheumatoid arthritis and to compare these markers with traditional ones such as C-reactive protein and erythrocyte sedimentation rate. Methods: Chitotriosidase, YKL-40 and C-reactive protein were measured in serum samples from 27 patients with rheumatoid arthritis and 27 healthy people. Chitotriosidase, YKL-40, C-reactive protein, and erythrocyte sedimentation rate were determined by a fluorometer, ELISA, nephelometer, and Western Green method, respectively. Results: Serum chitotriosidase activities and YKL-40 levels were higher in rheumatoid arthritis group than in control. A significant positive correlation was found between chitotriosidase and YKL-40. In ROC analysis, the areas under curves for chitotriosidase, C-reactive protein, erythrocyte sedimen-

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Increased level of YKL-40 in sera from patients with early rheumatoid arthritis: a new marker for disease activity

Cited by 57 publications

References 14 publications

Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis C

Relationship of serum fibrosis markers with liver fibrosis stage and collagen content in patients with advanced chronic hepatitis C

Serum matrix metalloproteinase 3 is an independent predictor of structural damage progression in patients with ankylosing spondylitis

Increased Chitotriosidase Activities in Patients with Rheumatoid Arthritis: A Possible Novel Marker?

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