Increased Levels and Activity of Matrix Metalloproteinase-9 in Obstructive Sleep Apnea Syndrome

Takagi, Toshiyuki; Minoguchi, Kenji; Yokoe, Takuya; Samson, Karen Thursday; Minoguchi, Hideko; Tanaka, Akihiko; Watanabe, Yoshio; Adachi, Mitsuru

doi:10.1164/rccm.200402-193oc

Cited by 86 publications

(82 citation statements)

References 39 publications

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“…In agreement with Tazaki, Ye, Feng and Volna [9,32,35,41], we observed in the whole group of OSAS subjects a positive correlation between MMP-9 and AHI, and between MMP-9 and ODI and also a negative correlation between MMP-9 and mSO 2 . In this study no significant correlation among MMP-2, TIMP-1, TIMP-2 and polysomnographic parameters was demonstrated.…”

Section: Discussionsupporting

confidence: 92%

“…The behavior of MMP-2 and MMP-9 agrees partially with the results observed by other authors [3,9,32,41] while our data regarding the tissue inhibitors are different from those of others [3,32] who did not find any variation of these TIMPs between OSAS subjects and control groups. In agreement with Tazaki, Ye, Feng and Volna [9,32,35,41], we observed in the whole group of OSAS subjects a positive correlation between MMP-9 and AHI, and between MMP-9 and ODI and also a negative correlation between MMP-9 and mSO 2 .…”

Section: Discussionsupporting

confidence: 82%

“…An altered expression of MMPs and TIMPs has been observed in OSAS. Tazaki et al observed a significant increase in MMP-9, but not in TIMP-1, serum levels in obese OSAS subjects compared to obese controls [32]. In addition, they found higher serum levels and activity of MMP-9 in subjects with moderate to severe OSAS than in subjects with mild disease [32].…”

Section: Introductionmentioning

confidence: 96%

“…In addition, they found higher serum levels and activity of MMP-9 in subjects with moderate to severe OSAS than in subjects with mild disease [32]. MMP-9 concentration and activity were significantly correlated with AHI, BMI and inflammatory cytokines, such as IL-6 and TNF-α [32]. Similarly, Ye et al [41] described elevated serum levels of MMP-9 in OSAS subjects in comparison with obese controls, correlated with OSAS severity and C-reactive protein levels.…”

Section: Introductionmentioning

confidence: 96%

“…Tazaki et al observed a significant increase in MMP-9, but not in TIMP-1, serum levels in obese OSAS subjects compared to obese controls [32]. In addition, they found higher serum levels and activity of MMP-9 in subjects with moderate to severe OSAS than in subjects with mild disease [32]. MMP-9 concentration and activity were significantly correlated with AHI, BMI and inflammatory cytokines, such as IL-6 and TNF-α [32].…”

Section: Introductionmentioning

confidence: 97%

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Gelatinases and their tissue inhibitors in a group of subjects with obstructive sleep apnea syndrome

Hopps¹,

Canino²,

Montana

et al. 2016

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Abstract. Obstructive sleep apnea syndrome (OSAS) is associated with an elevated risk of cardiovascular events and stroke. Matrix metalloproteinases (MMPs) are endopeptidases involved in extracellular matrix degradation and then in the development and progression of cardiovascular diseases. Our aim was to evaluate plasma levels of gelatinases (MMP-2 and MMP-9) and their tissue inhibitors (TIMP-1 and TIMP-2) in a group of subjects with OSAS. We enrolled 48 subjects (36 men and 12 women; mean age 49.7 ± 14.68 yrs) with OSAS diagnosed with a 1-night cardiorespiratory study and then we subdivided these subjects into two subgroups according to the apnea/hypopnea index (AHI): Low (L = 21 subjects with AHI <30) and High (H = 27 subjects with AHI >30). We measured plasma concentration of the gelatinases and their inhibitors using ELISA kits. We observed a significant increase in plasma concentration of MMP-9, MMP-2, TIMP-1 and TIMP-2 in the entire group of OSAS subjects and in the two subgroups, with higher levels in the H in comparison with the L subgroup. In the whole group of OSAS subjects we also noted a significant decrease in MMP-9/TIMP-1 ratio in comparison with normal controls. Only MMP-9 was significantly correlated with the severity of the disease, expressed as AHI, with the oxygen desaturation index and also with the mean oxygen saturation. MMPs pattern is altered in OSAS and significantly influenced by the severity of the disease; it probably contributes to the vascular remodeling that leads to the atherosclerotic disease and cardiovascular complications.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 97%

See 3 more Smart Citations

Gelatinases and their tissue inhibitors in a group of subjects with obstructive sleep apnea syndrome

Hopps¹,

Canino²,

Montana

et al. 2016

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Association of matrix metalloproteinase‐9 and nitric oxide with hypertension in obstructive sleep apnea

Zeng

Tang

et al. 2022

Laryngoscope Investig Oto

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Background Patients with obstructive sleep apnea (OSA) are more likely to suffer from hypertension. At the same time, the serum levels of matrix metalloproteinase‐9 (MMP‐9) and nitric oxide (NO) in patients with OSA are also changed in OSA patients. We investigated the correlation between serum levels of MMP‐9, NO in patients with OSA and their association with hypertension in those patients, and the effects of continuous positive airway pressure therapy (CPAP) on these serum biomarkers and blood pressure. Methods Serum MMP‐9 and NO levels and blood pressure of 57 patients with newly diagnosed OSA and 30 controls were measured; among them, 30 patients with moderate to severe OSA underwent 3‐month CPAP treatment. Results In comparison to the control group, the MMP‐9 serum levels were higher (232.8 ± 103.2 ng/ml versus 161.6 ± 56.5 ng/ml, p < .001*), there was no statistical significance difference among serum NO (26.7 ± 9.1 IU/ml versus 31.0 ± 11.7 IU/ml, p = .06), and MMP‐9 was negatively correlated to NO, especially in patients with hypertension (r = −.644, p = .02*). MMP‐9, NO, and blood pressure were significantly recovered in the patients with OSA after CPAP treatment for 3 months (p < .05*). Conclusion The MMP‐9 level and the NO level were altered in OSA patients. The relationship between the two especially in patients with hypertension suggests the potential mechanism of OSA‐induced hypertension.

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Adiposity and low‐grade systemic inflammation modulate matrix metalloproteinase‐9 levels in Greek children with sleep apnea

Kaditis

Alexopoulos

Karathanasi

et al. 2010

Pediatric Pulmonology

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BackgroundMatrix metalloproteinase‐9 (MMP‐9) plasma levels correlate with C‐reactive protein (CRP) concentrations and they are both increased in adults with obstructive sleep apnea (OSA). No studies have evaluated MMP‐9 levels in children with sleep apnea and CRP is not consistently elevated in pediatric OSA. The aim of this investigation was to evaluate the association of severity of OSA, adiposity, and CRP with MMP‐9 plasma levels in Greek children.MethodsConsecutive children with snoring who underwent polysomnography and were found to have OSA (obstructive apnea–hypopnea index—OAHI ≥ 1 episode/hr) were recruited. Subjects without OSA (OAHI < 1 episode/hr) were included for comparison. Morning plasma MMP‐9 and CRP were measured.ResultsTwenty‐nine children with moderate‐to‐severe OSA (age 5.4 ± 1.5 years; OAHI 13.9 ± 13.0 episodes/hr), 55 participants with mild OSA (6.4 ± 2.6 years; OAHI 2.4 ± 1.1 episodes/hr) and 22 subjects without OSA (6.8 ± 2.6 years; OAHI 0.6 ± 0.2 episodes/hr) were studied. Children with moderate‐to‐severe OSA were similar to those with mild OSA or without OSA regarding ln‐transformed MMP‐9 values (5.87 ± 0.60 vs. 5.84 ± 0.55 vs. 5.80 ± 0.46; P > 0.05) and CRP concentrations (0.22 ± 0.29 mg/dl vs. 0.21 ± 0.36 vs. 0.13 ± 0.16 mg/dl; P > 0.05). In multiple linear regression, body mass index (P = 0.027) and CRP levels (P = 0.008), but not OAHI or SpO2 nadir (P > 0.05), were significantly related to MMP‐9 values.ConclusionsAdiposity and systemic inflammation unrelated to OSA severity, modulate MMP‐9 levels in Greek children. Pediatr Pulmonol. 2010; 45:693–699. © 2010 Wiley‐Liss, Inc.

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Increased Levels and Activity of Matrix Metalloproteinase-9 in Obstructive Sleep Apnea Syndrome

Cited by 86 publications

References 39 publications

Gelatinases and their tissue inhibitors in a group of subjects with obstructive sleep apnea syndrome

Gelatinases and their tissue inhibitors in a group of subjects with obstructive sleep apnea syndrome

Association of matrix metalloproteinase‐9 and nitric oxide with hypertension in obstructive sleep apnea

Adiposity and low‐grade systemic inflammation modulate matrix metalloproteinase‐9 levels in Greek children with sleep apnea

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