Increased Levels and Pulsatility of Follicle-Stimulating Hormone in Mothers of Hereditary Dizygotic Twins

Lambalk, C.B.

doi:10.1210/jc.83.2.481

Cited by 35 publications

(25 citation statements)

References 13 publications

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“…Additionally, in mothers of familial dizygotic twins, higher FSH levels are associated with an increase in secretory drive of FSH instead of limitations in hormonal feedback, which is the case with reproductive aging (54).…”

Section: Hendriks Meta-analysis Of Afc Fertil Steril 2005mentioning

confidence: 99%

Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: A meta-analysis and comparison with basal follicle-stimulating hormone level

Hendriks

Mol

Bancsi

et al. 2005

Fertility and Sterility

344

191

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Result(s):We identified 11 studies on AFC and an updated total of 32 studies on basal FSH from the literature on the basis of preset criteria. The estimated summary receiver operating characteristic (ROC) curves showed AFC to perform well in the prediction of poor ovarian response. Also, prediction of poor ovarian response seemed to be more accurate with AFC compared with basal FSH. The estimated summary ROC curves for the prediction of nonpregnancy indicated a poor performance for both AFC and basal FSH. Conclusion(s):Transvaginal ultrasonography is an easy-to-perform and noninvasive method that provides essential predictive information on ovarian responsiveness. The predictive performance of AFC toward poor response is significantly better than that of basal FSH. Therefore, AFC might be considered the test of first choice in the assessment of ovarian reserve prior to IVF. (Fertil Steril 2005;83:291-301 Reproductive aging is associated with a reduction of the primordial follicle pool and loss of oocyte quality (1). The number of follicles leaving the pool of resting follicles to enter the growth phase toward the antral stages of development decreases with increasing age (2).In an IVF program, ovarian aging is characterized by decreased ovarian responsiveness to gonadotropin administration and lowered pregnancy rates. Correct identification of patients at risk of poor ovarian response by assessment of ovarian reserve before entering an IVF program is important.It can help physicians to tailor their advice to individual couples and help patients to decide whether to proceed with a costly and often demanding and disappointing IVF treatment.A recent meta-analysis on the performance of basal FSH level in the prediction of poor ovarian response and failure to become pregnant after IVF showed that a possible clinical application of basal FSH refers to only a minority of patients with extremely high basal FSH levels (3). However, to date basal FSH is still widely used in many fertility centers.Several other endocrine ovarian reserve tests have been proposed as predictors for IVF outcome in the past decade (4). In the field of quantitative ultrasonography, achievements in the development of tests that assess ovarian reserve have also been reported. After the initial reports by Reuss et al. (5) and Scheffer et al. (6) that transvaginal ultrasonography could detect age-related decreases in follicle counts,

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Section: Hendriks Meta-analysis Of Afc Fertil Steril 2005mentioning

confidence: 99%

Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: A meta-analysis and comparison with basal follicle-stimulating hormone level

Hendriks

Mol

Bancsi

et al. 2005

Fertility and Sterility

344

191

View full text Add to dashboard Cite

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“…The concentrations of follicle-stimulating hormone (FSH) above some threshold at the critical phase of the menstrual cycle contribute to selection of the dominant follicle (Baird, 1983;Macklon & Fauser, 2000) and paracrine signaling within the ovary influences FSH action in the follicle to regulate granulosa cell differentiation, follicle development and twinning rate (Erickson & Shimasaki, 2001;Matzuk et al, 2002). Concentrations of FSH are higher in mothers of DZ twins (MODZT) in some (Lambalk et al, 1998;Martin et al, 1984), but not all (Gilfillan et al, 1996) studies. No obvious differences were seen in concentrations of inhibin A or B in MODZT with or without double ovulations (Gilfillan et al, 2003), suggesting changes in endocrine signaling to the ovary may not be the primary mechanism responsible for DZ twinning.…”

mentioning

confidence: 99%

A Deletion Mutation in GDF9 in Sisters with Spontaneous DZ Twins

Montgomery¹,

Zhao²,

Marsh³

et al. 2004

Twin res.

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“…These observations lead to the hypothesis that there may be genetic factors responsible for both DZ twinning and larger testis size. The folliclestimulating hormone (FSH) may play a role in the association: mothers of DZ twins have shown increased FSH concentrations (Lambalk et al, 1998;Martin et al, 1984;Nylander, 1974), and smaller testes have been observed in men who lack a functional FSH receptor (Tapanainen et al, 1997). However, results from a study using a mouse model for the Fragile X syndrome (Slegtenhorst-Eegdeman et al, 1998), showed that macro-orchidism is caused by an increased rate of Sertoli cell proliferation in the Note: -2LL = -2 log likelihood, df = degrees of freedom, χ 2 = chi-square statistic, Δdf = difference in degrees of freedom, c.t.m.…”

Section: Discussionmentioning

confidence: 99%

Heritability of Testis Size

Burk

Bartels

Waal³

et al. 2009

Twin Res Hum Genet

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T estis size is an important feature of male pubertal development. The genetic and environmental contributions to variation in human testis size have hardly been studied. We estimated the heritability of human testicular size in a group of mono-and dizygotic twins and their non-twin brothers (145 twins and 20 brothers from 95 families). Participants were 18 years old on average and all had reached Tanner development stage 4 or higher. Dizygotic twins and their siblings had a larger mean testis volume than monozygotic twins and their siblings. There was significant familial resemblance, with higher correlations in monozygotic twin pairs (0.59) than in dizygotic twin and sibling pairs (0.34). Heritability was estimated at 59% (95% CI = 37-75%), but a model that excluded genetic influences and attributed all familial resemblance to shared environment, fitted the data only marginally worse. The finding of larger mean testis volume in dizygotic twins may be of interest for future research into the mechanisms underlying dizygotic twinning.

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Increased Levels and Pulsatility of Follicle-Stimulating Hormone in Mothers of Hereditary Dizygotic Twins

Cited by 35 publications

References 13 publications

Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: A meta-analysis and comparison with basal follicle-stimulating hormone level

Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: A meta-analysis and comparison with basal follicle-stimulating hormone level

A Deletion Mutation in GDF9 in Sisters with Spontaneous DZ Twins

Heritability of Testis Size

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