Increased Levels of Circulating Angiogenic Cells and Signaling Proteins in Older Adults With Cerebral Small Vessel Disease

Kapoor, Arunima; Gaubert, Aimée; Marshall, Amy; Meier, Irene B.; Yew, Belinda; Ho, Jean K.; Blanken, Anna E.; Dutt, Shubir; Sible, Isabel J.; Li, Yanrong; Jang, Jung Yun; Brickman, Adam M.; Rodgers, Kathleen E.; Nation, Daniel A.

doi:10.3389/fnagi.2021.711784

Cited by 24 publications

(17 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other measurements. Blood samples from venipuncture were also used to determine APOE e4 carrier status (≥ 1 e4 allele), as previously prescribed 61 . Genomic DNA was extracted using the PureLink Genomic DNA Mini Kit (Thermo).…”

Section: Methodsmentioning

confidence: 99%

Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults

Sible

Yew

Jang

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Blood pressure variability is an emerging risk factor for Alzheimer’s disease in older adults, independent of average blood pressure levels. Growing evidence suggests increased blood pressure variability is linked to Alzheimer’s disease pathophysiology indexed by cerebrospinal fluid and positron emission tomography markers, but relationships with plasma Alzheimer’s disease markers have not been investigated. In this cross-sectional study of 54 community-dwelling older adults (aged 55–88, mean age 69.9 [8.2 SD]), elevated blood pressure variability over 5 min was associated with lower levels of plasma Aβ1–42 (standardized ß = − 0.36 [95% CI − 0.61, − 0.12]; p = 0.005; adjusted R2 = 0.28) and Aβ1–42: Aβ1–40 ratio (ß = − 0.49 [95% CI − 0.71, − 0.22]; p < 0.001; adjusted R2 = 0.28), and higher levels of total tau (ß = 0.27 [95% CI 0.01, 0.54]; p = 0.04; adjusted R2 = 0.19) and Ptau181:Aβ1–42 ratio (ß = 0.26 [95% CI 0.02, 0.51]; p = 0.04; adjusted R2 = 0.22). Findings suggest higher blood pressure variability is linked to plasma biomarkers of increased Alzheimer’s disease pathophysiology.

show abstract

Section: Methodsmentioning

confidence: 99%

Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults

Sible

Yew

Jang

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Previous studies mainly focused on plasma measurements, which may be less accurate for changes in the central nervous system. 17,39 A weakness is the lack of patients with a diagnosis of vascular dementia. Since the cohort was recruited from a Swedish memory clinic (mainly Copyright © 2023 The Author(s).…”

Section: Growth Factors Of the Vegf Family Play An Important Role In ...mentioning

confidence: 99%

Associations Between CSF Markers of Inflammation, White Matter Lesions, and Cognitive Decline in Individuals Without Dementia

et al. 2023

View full text Add to dashboard Cite

Backgroundand ObjectivesSmall vessel disease (SVD) and neuroinflammation both occur in Alzheimer’s disease (AD), and other neurodegenerative diseases. It is unclear if these processes are related or independent mechanisms in AD, especially in the early stages of disease. We therefore investigated the association between white matter lesions (WML; the most common manifestation of SVD), and CSF biomarkers of neuroinflammation and their effects on cognition in a population without dementia.MethodsIndividuals without dementia from the Swedish BioFINDER study were included. CSF was analyzed for proinflammatory markers (interleukin [IL]–6, IL-8), cytokines (IL-7, IL-15, IL-16), chemokines (interferon-γ–induced protein 10 [IP-10], monocyte chemoattractant protein 1, markers of vascular injury (soluble intercellular adhesion molecule 1, soluble vascular adhesion molecule 1), and markers of angiogenesis (placental growth factor [PlGF], soluble fms-related tyrosine kinase 1 [sFlt-1], vascular endothelial growth factors [VEGF-A, and VEFG-D]), and Aβ42, Aβ40 and P-tau 217. WML volumes were determined at baseline and longitudinally over six years. Cognition was measured at baseline and follow-up over eight years. Linear regression models were used to test associations.Results495 cognitively unimpaired (CU) elderly and 247 patients with mild cognitive impairment (MCI) were included. There was significant worsening in cognition over time, measured by MMSE, CDR and mPACC in CU and MCI, with more rapid worsening in MCI for all cognitive tests. At baseline, higher levels of PlGF (β=0.156, p<0.001), lower levels of sFlt-1 (β=-0.086, p=0.003), and higher levels of IL-8 (β=0.07, p=0.030) were associated with more WML in CU. In MCI, higher levels of PlGF (β=0.172, p=0.001), IL-16 (β=0.125, p=0.001), IL-8 (β=0.096, p=0.013), IL-6 (β=0.088, p=0.023), VEGF-A (β=0.068, p=0.028), and VEGF-D (β=0.082, p=0.028) were associated with more WML. PlGF was the only biomarker that was associated with WML independent of Aβ status and cognitive impairment. Longitudinal analyses of cognition showed independent effects of CSF inflammatory markers and WML on longitudinal cognition, especially in people without cognitive impairment at baseline.DiscussionMost neuroinflammatory CSF biomarkers were associated with WML in individuals without dementia. Our findings especially highlight a role for PlGF, which was associated with WML independent of Aβ status and cognitive impairment.

show abstract

“…Likewise, a reduced number of EPCs has been shown in patients with migraines, especially during attacks ( Rodríguez-Osorio et al, 2012 ). Recently, a relationship has been observed between the elevated levels of EPCs and cerebral small vessel disease burden, which is a risk factor for the development of AD ( Kapoor et al, 2021 ). Curiously, sickle cell anemia (SCA) patients, a monogenic disease that affect erythrocyte membranes, present a high risk to develop a small vessels disease such as ischemic, hemorrhagic, and silent strokes ( Ito et al, 2020 ).…”

Section: Endothelial Progenitor Cells and Their Potential Role In Alz...mentioning

confidence: 99%

Endothelial Progenitor Cells and Vascular Alterations in Alzheimer’s Disease

Custodia

Ouro

Romaus-Sanjurjo

et al. 2022

Front. Aging Neurosci.

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is a neurodegenerative disease representing the most common type of dementia worldwide. The early diagnosis of AD is very difficult to achieve due to its complexity and the practically unknown etiology. Therefore, this is one of the greatest challenges in the field in order to develop an accurate therapy. Within the different etiological hypotheses proposed for AD, we will focus on the two-hit vascular hypothesis and vascular alterations occurring in the disease. According to this hypothesis, the accumulation of β-amyloid protein in the brain starts as a consequence of damage in the cerebral vasculature. Given that there are several vascular and angiogenic alterations in AD, and that endothelial progenitor cells (EPCs) play a key role in endothelial repair processes, the study of EPCs in AD may be relevant to the disease etiology and perhaps a biomarker and/or therapeutic target. This review focuses on the involvement of endothelial dysfunction in the onset and progression of AD with special emphasis on EPCs as a biomarker and potential therapeutic target.

show abstract

Increased Levels of Circulating Angiogenic Cells and Signaling Proteins in Older Adults With Cerebral Small Vessel Disease

Cited by 24 publications

References 36 publications

Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults

Blood pressure variability and plasma Alzheimer’s disease biomarkers in older adults

Associations Between CSF Markers of Inflammation, White Matter Lesions, and Cognitive Decline in Individuals Without Dementia

Endothelial Progenitor Cells and Vascular Alterations in Alzheimer’s Disease

Contact Info

Product

Resources

About