Increased levels of circulating intercellular adhesion molecule 1 in the sera of patients with rheumatoid arthritis

Cush, John J.; Rothlein, Robert; Lindsley, Herbert B.; Mainolfi, Elizabeth; Lipsky, Peter E.

doi:10.1002/art.1780360810

Cited by 87 publications

(52 citation statements)

References 15 publications

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“…A variety of serologic markers have been used to monitor the degree of disease activity in RA, and various new markers have been reported (28)(29)(30)(31). In this study, serum levels of MMP-3 were increased in RA and were correlated with disease activity and also with SF levels of MMP-3, whereas such a correlation was not observed for TIMP-I.…”

Section: Discussionmentioning

confidence: 62%

Increased levels of stromelysin‐1 and tissue inhibitor of metalloproteinases–1 in sera from patients with rheumatoid arthritis

Yoshihara

Obata²,

Fujimoto

et al. 1995

Arthritis & Rheumatism

117

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Objective. To evaluate the efficacy of stromelysin-1 (matrix metalloproteinase-3 [MMP3]) and tissue inhibitor of metalloproteinases-1 (TIMP-1) in serum as markers for joint inflammation in rheumatoid arthritis (RA).Methods. Levels of both macromolecules in sera from 97 healthy controls, 109 patients with RA, and 47 patients with osteoarthritis (OA) were measured by respective 1-step sandwich enzyme immunoassays. In the patients with RA, serum levels of MMP-3 and TIMP-1 were investigated in relation to laboratory and clinical measures of disease activity. In addition, the relationships between serum and synovial fluid (SF) levels in paired samples from individual patients were examined.Results. Serum levels of both MMP-3 and TIMP-1 in RA patients were significantly higher than those in OA patients and in healthy controls (P < 0.001), and were shown to correlate with traditional systemic markers of inflammation including the erythrocyte sedimentation rate and C-reactive protein level, and with the Lansbury articular index. In addition, it was noted that serum levels of MMP-3 correlated with the corresponding values in paired SF samples obtained concurrently from patients with RA (r, = 0.588, P <

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Section: Discussionmentioning

confidence: 62%

Increased levels of stromelysin‐1 and tissue inhibitor of metalloproteinases–1 in sera from patients with rheumatoid arthritis

Yoshihara

Obata²,

Fujimoto

et al. 1995

Arthritis & Rheumatism

117

View full text Add to dashboard Cite

show abstract

“…Unlike their levels in biopsy tissues, serum levels of adhesion molecules can be precisely quantified by enzyme-linked immunosorbent assay (ELISA). Circulating forms of E-selectin, ICAM-1, and VCAM-1 have been described (17), and elevated serum concentrations of ICAM-1 and VCAM-1 have been reported for patients with RA (18)(19)(20). In the case of soluble E-selectin, there have been reports of both unchanged (21) and elevated (22) serum levels in RA.…”

mentioning

confidence: 99%

Deactivation of vascular endothelium by monoclonal anti–tumor necrosis factor α antibody in rheumatoid arthritis

Paleolog

Hunt

Elliott

et al. 1996

Arthritis & Rheumatism

227

118

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Objective. To assess whether monoclonal antibody to tumor necrosis factor a (TNFa) reduces endothelial activation in rheumatoid arthritis (RA).Methods. Levels of serum E-selectin, intercellular adhesion molecule 1 (ICAM-l), and vascular cell adhesion molecule 1 (VCAM-l), and circulating leukocytes (differential counts) were measured in RA patients before and up to 4 weeks after infusion of either placebo or chimeric anti-TNFa antibody cA2 (1 or 10 mg/kg).Results. Treatment with anti-TNFa decreased serum E-selectin and ICAM-1 levels, with the earliest detectable changes observed on days 1-3 after anti-TNFa infusion. No effect on VCAM-1 levels was detected. In parallel, there was a rapid and sustained increase in circulating lymphocytes. The extent of the decrease in serum E-selectin and ICAM-1 levels and the increase in lymphocyte counts was significantly higher (P I 0.05) in patients in whom a clinical benefit of anti-TNFa was observed (120% response, by Paulus criteria, at week 4) compared with that in patients who failed to respond to anti-TNFa at this time point.Conclusion. We propose that decreased serum levels of adhesion molecules may reflect diminished activation of endothelial cells in the synovial microvas-

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“…P-selectin (GMP-140, PADGEM protein, orCD62) is a member of the selectin family of adhesion molecules and is a 140 kilodalton membrane protein stored both in the a-granules of platelets and in the Weibel-Palade bodies of endothelial cells (ECs) [1][2][3][4][5][6][7]. Upon the activation of these cells by strong agonists, e.g., thrombin, histamine and in normal human sera and in pathological sera including those of patients with connective tissue diseases and malignan cies [18][19][20][21][22][23]. It was suggested that the measurement of lev els of circulating soluble adhesion molecules is useful as an indicator of inflammatory disease.…”

Section: Introductionmentioning

confidence: 99%

Soluble P-Selectin in the Plasma of Patients with Connective Tissue Diseases

Takeda

Kaise

Nishimaki

et al. 1994

Int Arch Allergy Immunol

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We measured the soluble P-selectin (sP-selectin) in plasma of 54 patients with connective tissue diseases and 12 normal controls by a 2-step sandwich enzyme immunoassay. Our purpose was 2-fold: to determine (1) whether the level of sP-selectin of such patients is higher than normal, and (2), if it is, whether it correlates with any of the laboratory data currently available. The mean levels in patients with systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD) and rheumatoid arthritis (RA) were 306, 1,048 and 844 ng/ml, respectively, compared with 220 ng/ml for controls. The mean levels in patients with SLE and nephropathy, MCTD and either nephropathy or thrombosis, and malignant RA were 351, 1,116 and 1,721 ng/ml, respectively. No correlation was found between the levels of sP-selectin and other laboratory data (WBC, CRP, ESR, antinuclear antibody, RF, aCL) except the number of platelets (y = 0.057, r = 0.37). In the clinical course of patients with lupus nephritis and MCTD with nephropathy, sP-selectin became a sensitive parameter. Thus, the level of sP-selectin is higher than normal in patients with connective tissue diseases, especially when complications exist, and it does not correlate with any of the laboratory data currently available except the number of platelets. Measurement of sP-selectin levels should be included in the laboratory tests of patients with connective tissue diseases, especially when complicated by nephropathy or thrombosis.

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Increased levels of circulating intercellular adhesion molecule 1 in the sera of patients with rheumatoid arthritis

Cited by 87 publications

References 15 publications

Increased levels of stromelysin‐1 and tissue inhibitor of metalloproteinases–1 in sera from patients with rheumatoid arthritis

Increased levels of stromelysin‐1 and tissue inhibitor of metalloproteinases–1 in sera from patients with rheumatoid arthritis

Deactivation of vascular endothelium by monoclonal anti–tumor necrosis factor α antibody in rheumatoid arthritis

Soluble P-Selectin in the Plasma of Patients with Connective Tissue Diseases

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