Increased levels of cortisol are associated with the severity of experimental visceral leishmaniasis in a Leishmania (L.) infantum-hamster model

Barros-Gonçalves, Tayany de D.; Saavedra, A.; Silva-Couto, Luzinei da; Ribeiro‐Romão, Raquel Peralva; Bezerra-Paiva, Milla; Gomes-Silva, Adriano; Carvalho, Vinícius F.; Da‐Cruz, Alda Maria; Pinto, Eduardo Costa

doi:10.1371/journal.pntd.0009987

Cited by 5 publications

(5 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following this result, Barros‐Goncalves et al. (2021) found that cortisol level is associated with the severity of infection.…”

Section: Discussionmentioning

confidence: 73%

“…Virulence genes did not significantly affect cortisol levels in acute infection, while it does after 6 days; this could be due to the overexpression of virulence factors throughout the disease course. Following this result, Barros-Goncalves et al (2021) found that cortisol level is associated with the severity of infection.…”

Section: Ta B L E 4 Virulence Genes Profile Of the Recovered Aeromona...mentioning

confidence: 73%

See 1 more Smart Citation

The role of Aeromonas genotyping in virulence for Dicentrarchus labrax

Aboyadak,

Soliman,

Nageeb

et al. 2023

Journal of Fish Diseases

View full text Add to dashboard Cite

Aeromonas septicemia still represents a serious challenge facing the global aquaculture sector. In the present study, Aeromonas caviae and A. veronii were isolated from four diseased European seabass (Dicentrarchus labrax) farms experiencing a high mortality rate. Diseased fish showed haemorrhages on the external body surface with exophthalmia, cataracts, scale desquamation, skin ulcers and fin erosions. The most common post‐mortem findings were congested internal organs, particularly the liver and posterior kidney. Twenty‐eight A. Veronii and 11 A. caviae isolates were identified biochemically by the Vitek 2 system and then confirmed by PCR and phylogenetic analysis. Hemolysin (hlyA) and aerolysin (aer) were the most abundant virulence genes in the recovered isolates, followed by cytotoxic enterotoxin (act) and heat‐stable enterotoxin (ast). A. caviae was more virulent than A. veronii for D. labrax fingerlings as LD50 ranging between (>1 × 108–6.2 × 107) for A. veronii and (2.9 × 107–8.3 × 107) for A. caviae. The sensitivity test indicated the effectiveness of norfloxacin, doxycycline and oxytetracycline against the tested isolates. Serum cortisol significantly increased in the infected groups, while catalase and glutathione peroxidase activities significantly decreased at 2 days post‐infection (DPI) and then increased at 6 DPI. The presence of virulence genes was associated with bacterial pathogenicity expressed in fish mortality rate. Virulence genes also drastically affect cortisol levels more than catalase and glutathione peroxidase levels.

show abstract

“…Following this result, Barros‐Goncalves et al. (2021) found that cortisol level is associated with the severity of infection.…”

Section: Discussionmentioning

confidence: 73%

Section: Ta B L E 4 Virulence Genes Profile Of the Recovered Aeromona...mentioning

confidence: 73%

The role of Aeromonas genotyping in virulence for Dicentrarchus labrax

Aboyadak,

Soliman,

Nageeb

et al. 2023

Journal of Fish Diseases

View full text Add to dashboard Cite

show abstract

“…Virulence genes did not significantly affect cortisol levels in acute infection while it does after six days; this could be due to the overexpression of virulence factors throughout the disease course. Following this result, Barros-Goncalves et al (2021) found that cortisol level is associated with the severity of infection.…”

Section: Oreochromis Niloticusmentioning

confidence: 73%

The role of Aeromonas genotyping in virulence for Dicentrarchus labrax

Aboyadak,

Soliman,

Nageeb

et al. 2023

Preprint

View full text Add to dashboard Cite

Aeromonas septicemia still represents a serious challenge facing the global aquaculture sector. In the present study, Aeromonas caviae and Aeromonas veronii were isolated from four diseased European seabass (Dicentrarchus labrax) farms with a high mortality rate. Diseased fish showed haemorrhages on the external body surface with exophthalmia, cataract, scale desquamation, skin ulcers and fin erosions. The most common post-mortem findings were congested internal organs, particularly the liver and posterior kidney. Twenty-eight A. Veronii and 11 A. caviae isolates were identified biochemically by the Vitek 2 system and then confirmed by PCR and phylogenetic analysis. Hemolysin (hlyA) and aerolysin (aer) were the most abundant virulence genes in the recovered isolates followed by cytotoxic enterotoxin (act) and heat-stable enterotoxin (ast). A. caviae was more virulent than A. veronii for D. labrax fingerlings as LD50 ranging between (> 1 × 108 - 6.2 × 107) for A. veronii and (2.9 × 107 - 8.3 × 107) for A. caviae. Norfloxacin, doxycycline, and oxytetracycline are the most effective antibacterial drugs against the tested isolates. Serum cortisol significantly increased in the infected groups, while catalase and glutathione peroxidase activities significantly decreased at 2-day post-infection (DPI) and then increased at 6 DPI. Plasma cortisol level was affected by the virulence genes profile of challenging isolates meanwhile, liver catalase and glutathione peroxidase activities were not.

show abstract

“…For example, in case of African Trypanosomes HAT patients display higher serum levels of cortisol as compared to controls, probably reflecting a stress response to the ongoing inflammation ( 141 , 142 ). Similarly, modulations of cortisol levels and GC synthesis were documented to occur during experimental Leishmaniasis and Chagas disease ( 143 – 145 ). More recently SARS-Cov-2 infection was suggested to affect GC synthesis since cortisol levels were found to be lower in critically ill patients with COVID-19 as compared to those of non-COVID-19 critically ill patients.…”

Section: The Mif/glucocorticoid Dyadmentioning

confidence: 89%

The Role of MIF and IL-10 as Molecular Yin-Yang in the Modulation of the Host Immune Microenvironment During Infections: African Trypanosome Infections as a Paradigm

et al. 2022

View full text Add to dashboard Cite

African trypanosomes are extracellular flagellated unicellular protozoan parasites transmitted by tsetse flies and causing Sleeping Sickness disease in humans and Nagana disease in cattle and other livestock. These diseases are usually characterized by the development of a fatal chronic inflammatory disease if left untreated. During African trypanosome infection and many other infectious diseases, the immune response is mediating a see-saw balance between effective/protective immunity and excessive infection-induced inflammation that can cause collateral tissue damage. African trypanosomes are known to trigger a strong type I pro-inflammatory response, which contributes to peak parasitaemia control, but this can culminate into the development of immunopathologies, such as anaemia and liver injury, if not tightly controlled. In this context, the macrophage migration inhibitory factor (MIF) and the interleukin-10 (IL-10) cytokines may operate as a molecular “Yin-Yang” in the modulation of the host immune microenvironment during African trypanosome infection, and possibly other infectious diseases. MIF is a pleiotropic pro-inflammatory cytokine and critical upstream mediator of immune and inflammatory responses, associated with exaggerated inflammation and immunopathology. For example, it plays a crucial role in the pro-inflammatory response against African trypanosomes and other pathogens, thereby promoting the development of immunopathologies. On the other hand, IL-10 is an anti-inflammatory cytokine, acting as a master regulator of inflammation during both African trypanosomiasis and other diseases. IL-10 is crucial to counteract the strong MIF-induced pro-inflammatory response, leading to pathology control. Hence, novel strategies capable of blocking MIF and/or promoting IL-10 receptor signaling pathways, could potentially be used as therapy to counteract immunopathology development during African trypanosome infection, as well as during other infectious conditions. Together, this review aims at summarizing the current knowledge on the opposite immunopathological molecular “Yin-Yang” switch roles of MIF and IL-10 in the modulation of the host immune microenvironment during infection, and more particularly during African trypanosomiasis as a paradigm.

show abstract

Increased levels of cortisol are associated with the severity of experimental visceral leishmaniasis in a Leishmania (L.) infantum-hamster model

Cited by 5 publications

References 49 publications

The role of Aeromonas genotyping in virulence for Dicentrarchus labrax

The role of Aeromonas genotyping in virulence for Dicentrarchus labrax

The role of Aeromonas genotyping in virulence for Dicentrarchus labrax

The Role of MIF and IL-10 as Molecular Yin-Yang in the Modulation of the Host Immune Microenvironment During Infections: African Trypanosome Infections as a Paradigm

Contact Info

Product

Resources

About