Increased levels of MIP-1<i>α</i>in CSF and serum of ALS

Yang, Xi; Gao, Lina; Wu, Xiaoshu; Zhang, Y.; Zang, Dawei

doi:10.1111/ane.12513

Cited by 18 publications

(18 citation statements)

References 27 publications

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“…In addition, similar conclusions were reached in our previous report that MIP-1α is likely neuroprotective and possibly can monitor disease progression (Yang et al, 2016). Finally, MIP-1β was noted as exerting an unimpressive influence in neuroinflammation as observed by elevation only in the CSF.…”

Section: F I G U R E 3 Correlations Between the Level Of Biomarkers Insupporting

confidence: 88%

“…In the light of previous results demonstrating a correlation between MCP‐1 levels and disease severity (Tateishi et al., 2010), our study suggests that MCP‐1 has a predictive value for ALS progression and is possibly neurotoxic. In addition, similar conclusions were reached in our previous report that MIP‐1α is likely neuroprotective and possibly can monitor disease progression (Yang et al., 2016). Finally, MIP‐1β was noted as exerting an unimpressive influence in neuroinflammation as observed by elevation only in the CSF.…”

Section: Discussionmentioning

confidence: 99%

“…We previously reported that several cytokines are elevated in the CSF and serum of ALS patients (Gao, Zhou, Cai, Gong, & Zang, 2014; Gong, Gao, Guo, Lu, & Zang, 2015; Liu, Gao, & Zang, 2015; Yang, Gao, Wu, Zhang, & Zang, 2016). Here we expand on our earlier results by measuring a panel of factors in the CSF and serum from a larger group of ALS patients to intuitively and comprehensively show the differences in the factor levels between ALS patients and control subjects.…”

Section: Introductionmentioning

confidence: 99%

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Evaluating the levels of CSF and serum factors in ALS

et al. 2017

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ObjectivesThe aim of this study was to identify CSF and serum factors as biomarkers that may aid in distinguishing ALS patients from control subjects and predicting ALS progression as well as prognosis.MethodsSerum and CSF samples from 105 patients with ALS and 56 control subjects were analyzed for 13 factors using ELISA. The revised ALS functional rating scale (ALSFRS‐r) was used to evaluate the overall functional status of ALS patients, and we also followed up with ALS patients either by phone or with clinic visits for five years after enrollment in this study. Finally, we examined the correlations between factor levels and various clinical parameters and evaluated the predictive value for prognosis through a multivariate statistic model.ResultsA total of eight factors were obviously elevated in CSF, and twelve markers were increased in serum. In the correlation analyses, there were trends toward higher bFGF, VEGF, MIP‐1α levels in ALS with a longer disease duration and slower disease progression in both CSF and serum. Higher MCP‐1 levels were associated with worse disease severity and faster progression, and the IFN‐γ levels were positively associated with disease progression in either CSF or serum. Finally, a better prognosis was observed with higher levels bFGF in CSF and VEGF in CSF and serum; conversely, patients with higher levels of IFN‐γ in the CSF had shorter overall survival.ConclusionsWe demonstrated that a factor profile of ALS patients is distinct from control subjects and may be useful in clinical practice and therapeutic trials.

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Section: F I G U R E 3 Correlations Between the Level Of Biomarkers Insupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Evaluating the levels of CSF and serum factors in ALS

et al. 2017

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“…In patients with ALS, levels of several chemokines are increased in the serum or CSF, among which CCL3, CCL4 and CXCL10 showed a negative correlation with the disease progression rate of ALS (Table 2). [47][48][49][50] These results imply that T cells play a neuroprotective role even in patients with ALS. Previous studies showed that the elimination of functional T cells in SOD1 mice through deletion of RAG2, CD4 or T-cell receptor-b shortened survival times through modifying microglial functions (Table 1).…”

Section: Adaptive Immunity In Alsmentioning

confidence: 78%

“…Circulating T cells in the peripheral blood are recruited to the CNS likely through upregulation of chemokines mainly produced by activated microglia in ALS. In patients with ALS, levels of several chemokines are increased in the serum or CSF, among which CCL3, CCL4 and CXCL10 showed a negative correlation with the disease progression rate of ALS (Table ) . These results imply that T cells play a neuroprotective role even in patients with ALS.…”

Section: Adaptive Immunity In Alsmentioning

confidence: 87%

Neuroinflammation in motor neuron disease

Endo

Komine

Yamanaka

2016

Clinical & Exp Neuroim

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Increasing evidence suggests that the pathogenesis of neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) is not restricted to the neurons but attributed to the abnormal interactions of neurons and surrounding glial and lymphoid cells. These findings led to the concept of non-cell autonomous neurodegeneration. Neuroinflammation, which is mediated by activated glial cells and infiltrated lymphocytes and accompanied by the subsequent production of proinflammatory cytokines and neurotoxic or neuroprotective molecules, is characteristic to the pathology in ALS and is a key component for non-cell autonomous neurodegeneration. This review covers the involvement of microglia and astrocytes in the ALS mouse models and human ALS, and it also covers the deregulated pathways in motor neurons, which are involved in initiating the disease. Based on the cell-type specific pathomechanisms of motor neuron disease, targeting of neuroinflammation could lead to future therapeutic strategies for ALS and could be potentially applied to other neurodegenerative diseases.

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Normal aging, motor neurone disease, and Alzheimer’s disease are characterized by cortical changes in inflammatory cytokines

Tennakoon

Katharesan

Musgrave

et al. 2021

J of Neuroscience Research

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The role of increased brain inflammation in the development of neurodegenerative diseases is unclear. Here, we have compared cytokine changes in normal aging, motor neurone disease (MND), and Alzheimer's disease (AD). After an initial analysis, six candidate cytokines, interleukin (IL)-4, 5, 6, 10, macrophage inhibitory protein (MIP)-1α, and fibroblast growth factor (FGF)-2, showing greatest changes were assayed in postmortem frozen human superior frontal gyri (n = 12) of AD patients, aging and young adult controls along with the precentral gyrus (n = 12) of MND patients. Healthy aging was associated with decreased anti-inflammatory IL-10 and FGF-2 levels. AD prefrontal cortex was associated with increased levels of IL-4, IL-5, and FGF-2, with the largest increase seen for FGF-2. Notwithstanding differences in the specific frontal lobe gyrus sampled, MND patients' primary motor cortex (precentral gyrus) was associated with increased levels of IL-5, IL-6, IL-10, and FGF-2 compared to the aging prefrontal cortex (superior frontal gyrus). Immunocytochemistry showed that FGF-2 is expressed in neurons, astrocytes, and microglia in normal aging prefrontal cortex, AD prefrontal cortex, and MND motor cortex. We report that healthy aging and agerelated neurodegenerative diseases have different cortical inflammatory signatures that are characterized by increased levels of anti-inflammatory cytokines and call into question the view that increased inflammation underlies the development of agerelated neurodegenerative diseases.

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Increased levels of MIP-1αin CSF and serum of ALS

Abstract: MIP-1α levels increased in both CSF and serum of patients with ALS, and it may be a potential neuroprotective biomarker in ALS.

Cited by 18 publications

References 27 publications

Evaluating the levels of CSF and serum factors in ALS

Evaluating the levels of CSF and serum factors in ALS

Neuroinflammation in motor neuron disease

Normal aging, motor neurone disease, and Alzheimer’s disease are characterized by cortical changes in inflammatory cytokines

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