Increased Levels of miRNA-146a in Serum and Histologic Samples of Patients with Uveal Melanoma

Russo, Andrea; Caltabiano, Rosario; Longo, Antonio; Avitabile, Teresio; Franco, Livio; Bonfiglio, Vincenza; Puzzo, Lidia; Reibaldi, Michele

doi:10.3389/fphar.2016.00424

Cited by 32 publications

(29 citation statements)

References 41 publications

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“…It has been established that aberrant expression of miRNAs leads to progression and metastasis of several cancers. In the past decade, several studies have examined the role of microRNAs in pathogenesis and progression of UM by utilizing plasma [24], serum [25], cell lines [26][27][28][29], and clinical tissue specimens [21][22][23]30]. Uveal melanoma is a very rare cancer, making it difficult to obtain a large number of samples from a single institution.…”

Section: Discussionmentioning

confidence: 99%

Changes in microRNA expression associated with metastasis and survival in patients with uveal melanoma

2020

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Uveal melanoma (UM) is a major intraocular cancer that is molecularly distinct from cutaneous melanoma. Approximately half of patients with UM eventually develop metastasis. The prognosis of metastatic UM is poor, with a median overall survival (OS) of less than a year. In this study, we sought to identify microRNAs (miRNAs) associated with metastasis and OS in UM. We analyzed the miRNA expression and clinical outcomes data from The Cancer Genome Atlas (TCGA) dataset for UM. Differential expression analyses were conducted for each miRNA with respect everdevelopment of metastasis. Multiple survival analyses were done, using the Cox proportional hazards model, to evaluate interactions between miRNA expression, metastasis, and OS. A total of 22 miRNAs (3 upregulated and 19 downregulated) were differentially expressed between patients with vs. without metastatic UM. These 22 miRNAs could be grouped into four clusters based on similarities in expression patterns. Of the 22 miRNAs differentially expressed with respect to metastasis, 21 were significantly associated with OS. The expression of multiple miRNAs was significantly associated with metastasis and overall survival in patients with UM. Further investigation of these miRNAs as biomarkers and/or therapeutic targets is warranted in the push to improve outcomes for patients with metastatic UM.

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Section: Discussionmentioning

confidence: 99%

Changes in microRNA expression associated with metastasis and survival in patients with uveal melanoma

2020

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“…At the time of metastasis, miR-20a, miR-125b, miR-146a, miR-155 and miR-223 plasma levels had increased, and miR-181a decreased [117]. In serum samples from UM patients undergoing enucleation, eight differentially expressed miRNAs were identified (miR-146a, miR-523 upregulated; miR-19a, miR-30d, miR-127, miR-451, miR-518f and miR-1274B downregulated) compared with normal controls [118]. Furthermore, miR-146a was validated in formalin-fixed paraffin-embedded (FFPE) UM samples and confirmed to be upregulated [118].…”

Section: Blood Biomarkers In Ummentioning

confidence: 98%

MicroRNAs and Uveal Melanoma: Understanding the Diverse Role of These Small Molecular Regulators

Aughton

Kalirai

Coupland

2020

IJMS

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Uveal melanoma (UM) is a rare tumour of the eye, characterised by a high propensity to metastasise in half of all patients, most frequently to the liver. Although there are effective treatment options for the primary tumour, once metastasis has occurred prognosis is poor, with overall survival limited to months. Currently, there are no effective treatments for metastatic UM, despite the tumour having a well-defined signalling pathway to which many therapies have been directed. In an effort to develop novel treatment approaches, understanding the role of other signalling molecules, such as microRNAs, is fundamental. MicroRNAs (miRNAs) are small non-coding RNA molecules involved in posttranscriptional gene regulation, resulting in reduced target gene expression and subsequent protein translation. In UM, several dysregulated miRNAs have been proposed to play a functional role in disease progression, whereas others have been put forward as clinical biomarkers of high-risk disease following isolation from blood, plasma and exosomes. Most recently, analyses of large datasets have identified promising prognostic miRNA signatures and panels. This review navigates the plethora of aberrant miRNAs disclosed so far in UM, and maps these to signalling pathways, which could be targeted in future therapies for the disseminated disease.

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“…MiR-155 expression is upregulated in lung cancer, and it is positively correlated with the prognosis. [8][9][10][11][12][13][14][15] Therefore, it is speculated that miRNA is likely to be associated with some human tumors, a variety of miRNA expression abnormalities in malignant tumors, but most of the relationship between miRNA and cancer remains to be further studied.…”

Section: Introductionmentioning

confidence: 99%

miR-337 can be a key negative regulator in melanoma

Xiao

Yao

Zheng

et al. 2017

Cancer Biology & Therapy

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Incidence of melanoma is increasing annually worldwide. There remains a lack of suitable treatment methods which can significantly improve the 5-year survival rates of patients. It is established that micro RNAs (miRNAs) have important roles in the diagnosis and treatment of cancer. MiR-337 had been reported to regulate the development of variety of cancers, as a cancer suppressive factor. In our research we found that miR-337 had a lower expression in melanoma than adjacent tissues. The patients who had a lower miR-337 also got a worse survival. MiR-337 could target STAT3 to regulate the occurrence and development of melanoma. In summary, our findings suggest that the miR-337/STAT3 axis may serve as a potential target for the treatment of melanoma.

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Increased Levels of miRNA-146a in Serum and Histologic Samples of Patients with Uveal Melanoma

Cited by 32 publications

References 41 publications

Changes in microRNA expression associated with metastasis and survival in patients with uveal melanoma

Changes in microRNA expression associated with metastasis and survival in patients with uveal melanoma

MicroRNAs and Uveal Melanoma: Understanding the Diverse Role of These Small Molecular Regulators

miR-337 can be a key negative regulator in melanoma

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