Increased levels of osteopontin in sputum supernatant of smoking asthmatics

Hillas, Georgios; Loukides, Stelios; Κostikas, Κonstantinos; Simoes, Davina Camargo Madeira; Petta, Vasiliki; Konstantellou, Elissavet; Emmanouil, Philip; Papiris, Spyros; Koulouris, Nikolaos; Bakakos, Petros

doi:10.1016/j.cyto.2012.10.002

Cited by 32 publications

(23 citation statements)

References 36 publications

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“…In contrast, minimally invasive sputum fluids show better amplitude and facilitate the discrimination of the osteopontin levels between mild, moderate and severe/refractory asthma (112). In addition, theses studies showed a highly significant correlation with smoke-induced neutrophilic infiltration, but not with bronchial hyper-responsiveness (113). Furthermore, the MMP-9/TIMP ratio was demonstrated to correlate with disease severity (114,115) or airway remodelling (116), whereas VEGF correlates with airway vascular permeability index even in post-treatment asthmatics (117).…”

Section: Biomarkers Of Airway Remodellingmentioning

confidence: 96%

Current and future biomarkers in allergic asthma

Zissler

Bieren

Jakwerth

et al. 2016

Allergy

107

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Diagnosis early in life, sensitization, asthma endotypes, monitoring of disease and treatment progression are key motivations for the exploration of biomarkers for allergic rhinitis and allergic asthma. The number of genes related to allergic rhinitis and allergic asthma increases steadily; however, prognostic genes have not yet entered clinical application. We hypothesize that the combination of multiple genes may generate biomarkers with prognostic potential. The current review attempts to group more than 161 different potential biomarkers involved in respiratory inflammation to pave the way for future classifiers. The potential biomarkers are categorized into either epithelial or infiltrate-derived or mixed origin, epithelial biomarkers. Furthermore, surface markers were grouped into cell-typespecific categories. The current literature provides multiple biomarkers for potential asthma endotypes that are related to T-cell phenotypes such as Th1, Th2, Th9, Th17, Th22 and Tregs and their lead cytokines. Eosinophilic and neutrophilic asthma endotypes are also classified by epithelium-derived CCL-26 and osteopontin, respectively. There are currently about 20 epithelium-derived biomarkers exclusively derived from epithelium, which are likely to innovate biomarker panels as they are easy to sample. This article systematically reviews and categorizes genes and collects current evidence that may promote these biomarkers to become part of allergic rhinitis or allergic asthma classifiers with high prognostic value.

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Section: Biomarkers Of Airway Remodellingmentioning

confidence: 96%

Current and future biomarkers in allergic asthma

Zissler

Bieren

Jakwerth

et al. 2016

Allergy

107

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“…Th e healthy subjects were recruited from the staff of both departments and have also been used as a control group in previous studies of our group. 5 Th e study was approved by the ethics committees of both hospitals (Sotiria Hospital and Attikon Hospital Ethics Committee No:517/May 2008), and all subjects provided written informed consent.…”

Section: Subjectsmentioning

confidence: 99%

“…4 We have reported that sputum OPN levels are higher in patients with asthma who smoke compared with patients with asthma who are nonsmokers and in patients with severe refractory asthma compared with less severe forms of the disease. 5,6 Th e aim of the present study was to evaluate the levels of OPN in sputum supernatants of patients with COPD in comparison with healthy smokers and nonsmoking subjects. We hypothesized that sputum OPN would be elevated in patients with COPD compared with healthy control subjects and that it would be associated with infl ammatory cells and mediators involved in the ongoing airway infl ammation process observed in COPD.…”

mentioning

confidence: 99%

Increased Levels of Osteopontin in Sputum Supernatant in Patients With COPD

Papaporfyriou

Loukides

Κostikas

et al. 2014

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“…First, the history of cigarette smoking differed between the two groups. Some studies have reported that the sputum OPN level was elevated in patients with smoking-related interstitial lung disease26 and smoking-induced asthma27. They explained that increased OPN in sputum was associated with the accumulation of inflammatory cells such as macrophages or neutrophils.…”

Section: Discussionmentioning

confidence: 99%

Plasma Osteopontin Is a Useful Diagnostic Biomarker for Advanced Non-Small Cell Lung Cancer

et al. 2013

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BackgroundOsteopontin (OPN) and carbonic anhydrase IX (CAIX), which are expressed on the surface of tumor cells, are associated with hypoxia during tumor development and progression. However, the roles of these proteins in the plasma of patients with non-small cell lung cancer (NSCLC) are poorly understood. Herein, we hypothesized that plasma OPN and CAIX levels could be used as diagnostic and prognostic tumor markers in patients with NSCLC.MethodsFifty-three patients with NSCLC and 50 healthy control subjects were enrolled. We selected controls without malignancy and matched them with NSCLC patient cases according to age and gender. Blood samples were collected at the time of diagnosis; the plasma levels of OPN and CAIX were measured by enzyme-linked immunosorbent assays.ResultsThe plasma levels of OPN in the patients with NSCLC were significantly elevated as compared to those in the controls (p=0.016). However, there was no difference in the plasma level of CAIX between the NSCLC patients and controls. NSCLC patients with a distant metastasis had a remarkable increase in plasma OPN compared with patients without metastasis (p=0.026), but no such correlation was found for CAIX. There was no difference in overall survival rates according to the plasma level of OPN between the two groups (by Kaplan-Meier survival analysis).ConclusionPlasma OPN levels were elevated in patients with NSCLC as compared with the controls, with greater elevation of OPN levels in the advanced stages of disease. Therefore, plasma OPN may have utility as a diagnostic, but not prognostic, biomarker of advanced NSCLC.

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Increased levels of osteopontin in sputum supernatant of smoking asthmatics

Cited by 32 publications

References 36 publications

Current and future biomarkers in allergic asthma

Current and future biomarkers in allergic asthma

Increased Levels of Osteopontin in Sputum Supernatant in Patients With COPD

Plasma Osteopontin Is a Useful Diagnostic Biomarker for Advanced Non-Small Cell Lung Cancer

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