Increased levels of serum interleukin-12 in Graves' disease

Tamaru, Masaaki; Matsuura, Bunzo; Onji, Morikazu

doi:10.1530/eje.0.1410111

Cited by 34 publications

(30 citation statements)

References 34 publications

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“…ported in patients with GD [21][22][23]. The increased expression of IL-12 mRNA in thyroid and orbital fat tissues has been reported in GD and in active GO, respectively [24,25].…”

Section: Discussionmentioning

confidence: 91%

“…IL-12 induces IL-2, IFN-γ and TNF-β from Th1 cells and IFN-γ from NK (natural killer) cells. Increased serum levels of IL-12 have been reported in GD [21][22][23]. Furthermore, IL-12B mRNA expression has been demonstrated in thyroid tissues from patients with GD [24] and in orbital fat tissues from patients with active GO [25], but not in extraocular muscle tissues (EOM), or EOM-derived T cell lines from patients with GO undergoing corrective strabismus surgery [26].…”

mentioning

confidence: 99%

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Interleukin-12B Gene Polymorphism does not Confer Susceptibility to Graves' Ophthalmopathy in Japanese Population

et al. 2006

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Abstract. Graves' disease (GD) is an autoimmune disorder with genetic predisposition and frequently associated with Graves' ophthalmopathy (GO). Interleukin 12 (IL-12) is an important mediator of inflammatory immune responses and is expressed in the thyroid and orbit. IL-12B gene, which encodes the p40 subunit of IL-12, is located at chromosome 5q31-33. The aim of the present study was to investigate whether IL-12B gene polymorphism is associated with the development of GD or GO. IL-12B gene polymorphism was studied in Japanese GD patients (n = 329) and healthy control subjects without anti-thyroid autoantibodies or a family history of autoimmune disorders (n = 226). The A/C polymorphism at position 1188 of the 3' untranslated region (3'UTR) of the IL-12B gene was analyzed using the polymerase chain reaction -restriction fragment length polymorphism method. There was no difference in allele or genotype frequency of the IL-12B gene polymorphism (1188A/C) between GD patients and control subjects. There was no association of the IL-12B gene polymorphism with ophthalmopathy, severity of hyperthyroidism or serum IgE levels. There was no association of the IL-12B gene polymorphism with serum IL-12 levels, which were significantly elevated in hyperthyroid phase of GD. In conclusion, IL-12B gene 1188A/C polymorphism is not associated with GD or GO susceptibility in Japanese.

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“…ported in patients with GD [21][22][23]. The increased expression of IL-12 mRNA in thyroid and orbital fat tissues has been reported in GD and in active GO, respectively [24,25].…”

Section: Discussionmentioning

confidence: 91%

mentioning

confidence: 99%

Interleukin-12B Gene Polymorphism does not Confer Susceptibility to Graves' Ophthalmopathy in Japanese Population

et al. 2006

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“…Increased serum levels of IL-12 have been reported in patients with Graves' disease as well as those with silent thyroiditis [25,26]. It was also reported that IL-12 is involved in the development of animal experimental AITD [27].…”

Section: Discussionmentioning

confidence: 97%

Lack of Association between IL-12B Gene Polymorphism and Autoimmune Thyroid Disease in Japanese Patients

et al. 2004

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Abstract. Interleukin (IL)-12 is a key factor in cell-mediated immunity that drives the development of Th1 cells and stimulates T lymphocytes and natural killer cells to produce interferon (INF)-g. The IL-12B gene, which encodes the p40 subunit of IL-12, is located at chromosome 5q31-33 and a linkage finding for autoimmune thyroid disease (AITD) on 5q31-33 in a Japanese population has been reported. It is also reported that the A/C polymorphism in the 3' untranslated region (UTR) of the IL-12B gene (1188A/C) is associated with IL12B mRNA expression levels. We attempted to determine whether genetic polymorphisms of the IL-12B gene are associated with AITD. One hundred three patients with Hashimoto's thyroiditis, 90 patients with Graves' disease, and 123 healthy control subjects were recruited. We detected the 1188A/C polymorphism using a PCR-RFLP method and the A/T polymorphism in intron 4 of the IL-12B gene using a cycle sequencing method. These IL-12B gene polymorphisms showed strong linkage disequilibrium, and their genotype and allele frequencies in the patients did not differ from those in the control subjects. Our results suggest that IL-12B gene polymorphisms were unlikely to have an effect on the development of Hashimoto's thyroiditis or Graves' disease in Japanese patients.

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“…Serum levels of IL-18 have consistently been reported to be elevated in patients with type 2 diabetes mellitus [20,23,24]. Previously, we reported the levels of several cytokines such as IL-12 and IL-18 to be increased in hyperthyroid Graves' disease [8,25]. A previous study reported that serum levels of IL-18 increase in patients with Graves' ophthalmopathy [26]; induces insulin resistance in mice.…”

Section: Fig 2 Serial Changes In Serum Il-18 Levels In Patients Withmentioning

confidence: 99%

Interleukin-18 induces insulin resistance in the hyperthyroid state

et al. 2013

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Increased levels of serum interleukin-12 in Graves' disease

Cited by 34 publications

References 34 publications

Interleukin-12B Gene Polymorphism does not Confer Susceptibility to Graves' Ophthalmopathy in Japanese Population

Interleukin-12B Gene Polymorphism does not Confer Susceptibility to Graves' Ophthalmopathy in Japanese Population

Lack of Association between IL-12B Gene Polymorphism and Autoimmune Thyroid Disease in Japanese Patients

Interleukin-18 induces insulin resistance in the hyperthyroid state

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