Increased Levels of Serum Uric Acid among Ex-smokers

Tomita, Mizuki; Mizuno, Shoichi; Yokota, Kazuhiko

doi:10.2188/jea.je2006332

Cited by 30 publications

(18 citation statements)

References 5 publications

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“…10 , 47 It has been suggested that smoking may suppress uric acid levels via the action of the superoxides found in cigarette smoke. 16 Given that the effects Total non-occupational physical activity, which included leisure time, daily living, and commuting-related physical activity, was inversely related to the prevalence of hyperuricemia ( Table 3 ). The ORs for ≤3, >3-6, >6-9, >9-12, and >12 non-occupational METs were 1.00, 0.80, 0.73, 0.75, and 0.57 ( P < 0.001), respectively, in fully adjusted analyses (including BMI and WHR), showing a dose-response relationship.…”

Section: Resultsmentioning

confidence: 99%

Prevalence and Determinants of Hyperuricemia in Middle-Aged, Urban Chinese Men

Villegas

Xiang

Cai

et al. 2010

Metabolic Syndrome and Related Disorders

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Background: Hyperuricemia is associated with metabolic syndrome and has emerged as a marker for both type 2 diabetes and cardiovascular disease. We estimated the prevalence and lifestyle risk factors of hyperuricemia in middle-aged, urban Chinese men. Methods: The study included 3,978 urban Chinese men 40-74 years of age from a population-based cohort study, the Shanghai Men's Health Study, who were free of type 2 diabetes at baseline and had provided fasting blood samples. Uric acid concentrations were measured by the uricase method. Hyperuricemia was defi ned as >7.0 mg/dL. Anthropometric measurements and information on lifestyle factors and disease history were collected by in-person interviews. Results: One quarter of the study subjects had hyperuricemia. Participants with metabolic syndrome had a higher prevalence of hyperuricemia. Body mass index (BMI), waist-to-hip ratio (WHR), waist circumference, and weight gain (since age 20) were positively associated with the prevalence of hyperuricemia. Physical activity was inversely related to the prevalence of hyperuricemia. The odds ratios for hyperuricemia for quintiles of nonoccupational physical activity were 1.00, 0.80, 0.73, 0.75, and 0.57 ( P trend <0.001). Participants with hyperuricemia were less likely to be current smokers, but were more likely to drink alcohol regularly. Beer consumption was associated with higher risk of hyperuricemia compared with consumption of wine or liquor. Conclusions: In this representative sample of middle-aged, urban Chinese men, hyperuricemia is highly prevalent. Obesity, weight gain in adulthood, and alcohol intake were associated with a higher prevalence of hyperuricemia, whereas daily physical activity and smoking were inversely related to the prevalence of hyperuricemia.

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Section: Resultsmentioning

confidence: 99%

Prevalence and Determinants of Hyperuricemia in Middle-Aged, Urban Chinese Men

Villegas

Xiang

Cai

et al. 2010

Metabolic Syndrome and Related Disorders

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“…Due to the possible impact of these effects, all patients with diabetes were excluded from the analysis. Although increased levels of SUA among ex-smokers have been previously described [36], an acceptable explanation of this phenomenon has not yet been found. Although several studies [37,38] have partly explained the cardiovascular benefit of the uricosuric effect from fenofibrate, losartan and atorvastatin, our patients were recruited before the losartan and atorvastatin era and, therefore, only a small number of patients (13%) were treated with ACEIs while none were treated with statins.…”

Section: Discussionmentioning

confidence: 99%

Serum Uric Acid for Risk Stratification of Patients with Coronary Artery Disease

et al. 2009

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Objectives: In patients with coronary artery disease (CAD), elevated serum uric acid (SUA) levels may predict worse cardiovascular outcomes. It is known that SUA levels are influenced by renal function. We aimed to assess the predictive value of SUA while taking into account patients’ renal function. Methods: The primary end point (PEP) risk, including fatal or nonfatal myocardial infarction (MI) or sudden death, was assessed by SUA quintiles before and after adjustment for the estimated glomerular filtration rate (eGFR) in 2,796 nondiabetic CAD patients enrolled in the Bezafibrate Infarction Prevention study. Results: The PEP risk increased from the lowest (11.8%) to highest SUA quintile (18.0%), p < 0.005, respectively. After adjustment for age, sex, smoking, prior MI, metabolic syndrome variables, NYHA classes II–IV, heart rate and treatment with bezafibrate, diuretics, angiotensin-converting enzyme inhibitors, β-blockers, calcium channel blockers and antiplatelets, the highest SUA quintile exhibited the highest PEP risk [hazard ratio (HR): 1.47 (95% CI: 1.06–2.04)]. Patients in the highest – compared with those in the lowest – quintiles continued to demonstrate an increased PEP risk [HR: 1.46 (95% CI: 1.04–2.06)], even after additional adjustment for the eGFR. Conclusion: In nondiabetic patients with CAD, elevated SUA levels are associated with an increased risk of cardiac events, independent of renal function.

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“…Its serum levels (SUA), governed by the production (liver) and elimination (mainly the kidney) rates, are influenced by genetically determined factors (eg, activity of synthesizing enzymes or renal transporter systems), racial and demographic characteristics (eg, sex, gonadal function in women, obesity), diet (eg, purine-rich foods, fructose, alcohol), habits (eg, SUA is lower in smokers and increases after quitting), morbidity (eg, heart or renal failure, malignancies), and medications (eg, diuretics, cytotoxic agents) (1)(2)(3)(4). The role of SUA in cardiovascular and renal diseases has been intensively investigated, although not without controversy (5).…”

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confidence: 99%

Higher Serum Uric Acid on Admission Is Associated with Higher Short-term Mortality and Poorer Long-term Survival After Myocardial Infarction: Retrospective Prognostic Study

Car

Trkulja

2009

Croat Med J

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Aim To assess serum uric acid (SUA) levels determined on admission as a potential predictor of short-term mortality and long-term survival in acute myocardial infarction (AMI) patients.Method Data for this retrospective prognostic study were drawn from the patient database of the Varaždin County General Hospital in Varaždin, Croatia. We included consecutive patients with verified AMI admitted within 48 hours since the symptom onset during the period between 1 January 1996 and 31 December 2001. Long-term survival/mortality data were collected through direct contacts with patients and search of the community death registries. Relative risks (RR) and hazard ratios (HR) by 10 µmol/ L increase in SUA were determined using modified Poisson regression with robust error variance and proportional hazard regression, respectively. Results A total of 621 patients (age 27-90 years, 64.7% men, 77.5% AMI with ST elevation, SUA 63-993 µmol/L) were included. Higher SUA on admission was independently associated with higher in-hospital mortality (RR, 1.016; 95% confidence interval [CI], 1.001-1.031, P = 0.043) and higher thirty-day mortality (RR, 1.016; 95% CI, 1.003-1.029, P = 0.018). Considered covariates were demographics, preindex event cardiovascular morbidity and treatment, onadmission serum creatinine, total cholesterol and triglycerides, AMI characteristics, and peak creatine phosphokinase. Higher SUA on admission was also independently associated with poorer long-term survival (ie, higher all-cause mortality) (HR, 1.105; 95% CI, 1.020-1.195, P = 0.010). Considered covariates were demographics, laboratory variables on admission, AMI characteristics, peak creatine phosphokinase, acute complications, and treatment at discharge. ConclusionHigher serum uric acid determined on admission is associated with higher in-hospital mortality and thirty-day mortality and poorer long-term survival after AMI.

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Increased Levels of Serum Uric Acid among Ex-smokers

Cited by 30 publications

References 5 publications

Prevalence and Determinants of Hyperuricemia in Middle-Aged, Urban Chinese Men

Prevalence and Determinants of Hyperuricemia in Middle-Aged, Urban Chinese Men

Serum Uric Acid for Risk Stratification of Patients with Coronary Artery Disease

Higher Serum Uric Acid on Admission Is Associated with Higher Short-term Mortality and Poorer Long-term Survival After Myocardial Infarction: Retrospective Prognostic Study

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