Increased levels of soluble <scp>HLA</scp>‐G molecules in Tunisian patients with chronic hepatitis B infection

Laaribi, Ahmed Baligh; Bortolotti, Daria; Hannachi, Naila; Mehri, A.; Hazgui, Olfa; Yahia, Hamza Ben; Babay, Wafa; Belhadj, M.; Chaouech, H.; Yacoub, S.; Létaief, A.; Ouzari, Hadda‐Imene; Boudabous, Abdellatif; Luca, Dario Di; Boukadida, Jalel; Rizzo, Roberta; Zidi, Inès

doi:10.1111/jvh.12718

Cited by 15 publications

(10 citation statements)

References 42 publications

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“…Thus, most features of the immune response, including differentiation, proliferation, cell lysis, cytokine production, and immunoglobulin release, can be inhibited by sHLA-G [15] , [33] . This is apparent in viral infections and patients infected with human immunodeficiency virus [34] , human cytomegalovirus [35] , herpes simplex type I virus [36] , H1N1 influenza virus [37] or hepatitis B virus [38] have shown up-regulated expression of cell-bound HLA-G or sHLA-G molecules, which were associated with persistent viral infection. On the contrary, a down-regulated expression of the HLA-G5 isoform was found in cervical cancer cases infected with human papillomavirus [39] .…”

Section: Discussionmentioning

confidence: 99%

Soluble HLA-G is upregulated in serum of patients with severe COVID-19

Al-Bayatee

Ad’hiah

2021

Human Immunology

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Soluble HLA-G (sHLA-G) molecules are considered potent immunomodulators, and their dysregulated expression has been implicated in several pathological conditions, including coronavirus disease 19 (COVID-19). Therefore, a case-control study (103 COVID-19 patients and 105 controls) was performed to determine sHLA-G role in severity of COVID-19. Results revealed that median levels of sHLA-G were significantly increased in serum of patients compared to controls (19.3 vs . 12.7 ng/mL; p < 0.001). When patients and controls were stratified by age group, gender, body mass index, chronic disease, or ABO and Rh blood groups, the sHLA-G level did not show a significant difference in each stratum. Logistic regression analysis demonstrated that the up-regulated expression of sHLA-G was associated with an elevated risk of developing COVID-19. Receiver operating characteristic curve analysis showed that sHLA-G was a very good predictor of COVID-19, and at a cut-off value of 15.4 ng/mL, the sensitivity and specificity of sHLA-G were 79.6 and 79.0%, respectively. Spearman rank correlation analysis revealed that sHLA-G was positively correlated with age, erythrocyte sedimentation rate, white blood cell count, and random blood glucose, while a negative correlation was recorded with vitamin D. In conclusion, up-regulated expression of sHLA-G was indicated in patients with severe COVID-19.

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Section: Discussionmentioning

confidence: 99%

Soluble HLA-G is upregulated in serum of patients with severe COVID-19

Al-Bayatee

Ad’hiah

2021

Human Immunology

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“…As described for HCV-infected tissues, HLA-G is expressed at a high frequency in HBV-infected liver biopsies, but not in control hepatocytes ( 106 ). Furthermore, sHLA-G levels were also significantly higher in HBV-infected patients when compared to healthy controls ( 15 , 107 , 108 ). The HBV-mediated induction of HLA-G expression in hepatocytes might be caused by modulation of the hepatocyte expression of miRs, such as downregulation of the HLA-G-regulating miR-152 representing the most HLA-G mRNA affine member of the miR-148 family leading to neoexpression of HLA-G ( 109 ).…”

Section: Role Of Hla-g In Viral Infections – Expression Mechanisms An...mentioning

confidence: 90%

Role of HLA-G in Viral Infections

et al. 2022

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The human leukocyte antigen (HLA)-G is a non-classical HLA class I molecule, which has distinct features to classical HLA-A, -B, -C antigens, such as a low polymorphism, different splice variants, highly restricted, tightly regulated expression and immune modulatory properties. HLA-G expression in tumor cells and virus-infected cells, as well as the release of soluble HLA-G leads to escape from host immune surveillance. Increased knowledge of the link between HLA-G expression, viral infection and disease progression is urgently required, which highlights the possible use of HLA-G as novel diagnostic and prognostic biomarker for viral infections, but also as therapeutic target. Therefore, this review aims to summarize the expression, regulation, function and impact of HLA-G in the context of different viral infections including virus-associated cancers. The characterization of HLA-G-driven immune escape mechanisms involved in the interactions between host cells and viruses might result in the design of novel immunotherapeutic strategies targeting HLA-G and/or its interaction with its receptors on immune effector cells.

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“…The potential advantage of soluble HLA-G as a biomarker has already been proposed in cancer, chronic viral infections and in vitro fertilization 20–22 . Our results are consistent with the potential value of sHLA-G from a public health point of view to identify pregnancies that could result in particularly frail newborns.…”

Section: Discussionmentioning

confidence: 99%

“…The soluble isoforms detected in the plasma are shed HLA-G1 (HLA-G1s) and HLA-G5 11 . Apart from pregnancy, HLA-G has been described associated with chronic viral infections, cancer and in vitro fertilization success 17–22 . During viruses’ infections, HLA-G can be over-expressed by infected cells to create a tolerogenic environment helping the pathogen to escape immune system 23 .…”

Section: Introductionmentioning

confidence: 99%

High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy

d’Almeida

Sadissou

Sagbohan

et al. 2019

Sci Rep

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Placental malaria has been associated with an immune tolerance phenomenon and a higher susceptibility to malaria infection during infancy. HLA-G is involved in fetal maternal immune tolerance by inhibiting maternal immunity. During infections HLA-G can be involved in immune escape of pathogens by creating a tolerogenic environment. Recent studies have shown an association between the risk of malaria and HLA-G at both genetic and protein levels. Moreover, women with placental malaria have a higher probability of giving birth to children exhibiting high sHLA-G, independently of their own level during pregnancy. Our aim was to explore the association between the level of maternal soluble HLA-G and the risk of malaria infection in their newborns. Here, 400 pregnant women and their children were actively followed-up during 24 months. The results show a significant association between the level of sHLA-G at the first antenatal visit and the time to first malaria infection during infancy adjusted to the risk of exposure to vector bites (aHR = 1.02, 95%CI [1.01–1.03], p = 0.014). The level of sHLA-G is a significant predictor of the occurrence of malaria infection during infancy consistent with the hypothesis that mother sHLA-G could be a biomarker of malaria susceptibility in children.

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Increased levels of soluble HLA‐G molecules in Tunisian patients with chronic hepatitis B infection

Cited by 15 publications

References 42 publications

Soluble HLA-G is upregulated in serum of patients with severe COVID-19

Soluble HLA-G is upregulated in serum of patients with severe COVID-19

Role of HLA-G in Viral Infections

High level of soluble human leukocyte antigen (HLA)-G at beginning of pregnancy as predictor of risk of malaria during infancy

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