Increased lipopolysaccharide-induced tumour necrosis factor-?, interferon-? and interleukin-10 production in atopic dermatitis

Simon, Dagmar; Lr, Braathen; Simon, Hans‐Uwe

doi:10.1111/j.1365-2133.2007.08050.x

Cited by 27 publications

(13 citation statements)

References 13 publications

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“…As noted by Niwa [23]; plasma levels of IL-10 seem to correlate inversely with the severity of AD. However, increased production of IL-10 has been demonstrated by other studies [21, 24]. T cells stimulated with IL-12 showed induction of IL-10 in vitro [25].…”

Section: Resultsmentioning

confidence: 90%

The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced byDermatophagoides farinaeAllergen in NC/Nga Mice

Ignacio

Kwak

Yun

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Hydrogen water (HW) produced by electrolysis of water has characteristics of extremely low oxidation-reduction potential (ORP) value and high dissolved hydrogen (DH). It has been proved to have various beneficial effects including antioxidant and anti-inflammatory effects; however, HW effect on atopic dermatitis (AD), an inflammatory skin disorder, is poorly documented. In the present study, we examined the immunological effect of drinking HW on Dermatophagoides farinae-induced AD-like skin in NC/Nga mice. Mice were administered with HW and purified water (PW) for 25 days. We evaluated the serum concentration of pro-inflammatory (TNF-α), Th1 (IFN-γ, IL-2, and IL-12p70), Th2 (IL-4, IL-5, and IL-10), and cytokine expressed by both subsets (GM-CSF) to assess their possible relationship to the severity of AD. The serum levels of cytokines such as IL-10, TNF-α, IL-12p70, and GM-CSF of mice administered with HW was significantly reduced as compared to PW group. The results suggest that HW affects allergic contact dermatitis through modulation of Th1 and Th2 responses in NC/Nga mice. This is the first note on the drinking effect of HW on AD, clinically implying a promising potential remedy for treatment of AD.

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Section: Resultsmentioning

confidence: 90%

The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced byDermatophagoides farinaeAllergen in NC/Nga Mice

Ignacio

Kwak

Yun

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…We hypothesized that the genetic background, with an important component of African ancestry and a different distribution of susceptibility alleles for eczema could be protective. Also, particular exposures of these children, with early infections as a hallmark, may confer protection, as has been suggested [56,85]. The diagnostic criteria we used [30] are very important when aiming to study this disease in the tropics because infections and other medical conditions producing "itchy skin" are very frequent.…”

Section: Discussionmentioning

confidence: 99%

Particular characteristics of allergic symptoms in tropical environments: follow up to 24 months in the FRAAT birth cohort study

et al. 2012

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Background: Early wheezing and asthma are relevant health problems in the tropics. Mite sensitization is an important risk factor, but the roles of others, inherent in poverty, are unknown. We designed a birth-cohort study in Cartagena (Colombia) to investigate genetic and environmental risk factors for asthma and atopy, considering as particular features perennial exposure to mites, parasite infections and poor living conditions. Methods: Pregnant women representative of the low-income suburbs of the city were randomly screened for eligibility at delivery; 326 mother-infant pairs were included at baseline and biological samples were collected from birth to 24 months for immunological testing, molecular genetics and gene expression analysis. Pre and post-natal information was collected using questionnaires.

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“…In contrast to these findings, other studies have shown either elevated IL-10 levels in PBMC’s isolated from AD patients [148], in lesional skin [149–151], or increased induction of IL-10 in PHA stimulated blood cultures from subjects with AD [152] or PBMC’s [148] and monocytes [151] stimulated with LPS. Elevated numbers of CD4+ and CD8+ cells expressing IL-10 were also observed in patients with AD [79].…”

Section: Th2 Cytokinesmentioning

confidence: 95%

Th2 Cytokines and Atopic Dermatitis

Brandt

Sivaprasad

2011

J Clin Cell Immunol

543

433

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Atopic dermatitis (AD), a chronic relapsing inflammatory skin disease, is increasing in prevalence around the world. Intensive research is ongoing to understand the mechanisms involved in the development of AD and offer new treatment options for patients suffering from AD. In this review, we highlight the importance of allergic Th2 responses in the development of the disease and summarize relevant literature, including genetic studies, studies of human skin and mechanistic studies on keratinocytes and mouse models of AD. We discuss the importance of the skin barrier and review recent findings on the pro-Th2 cytokines TSLP, IL-25, and IL-33, notably their ability to polarize dendritic cells and promote Th2 responses. After a brief update on the contribution of different T-cell subsets to AD, we focus on Th2 cells and the respective contributions of each of the Th2 cytokines (IL-4, IL-13, IL-5, IL-31, and IL-10) to AD. We conclude with a brief discussion of the current gaps in our knowledge and technical limitations.

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Increased lipopolysaccharide-induced tumour necrosis factor-?, interferon-? and interleukin-10 production in atopic dermatitis

Abstract: These results demonstrate that the effects of LPS stimulation depend on both the type of cytokine and the origin of PBMC. Endotoxin exposure is suggested to modulate the disease course of AD.

Cited by 27 publications

References 13 publications

The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced byDermatophagoides farinaeAllergen in NC/Nga Mice

The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced byDermatophagoides farinaeAllergen in NC/Nga Mice

Particular characteristics of allergic symptoms in tropical environments: follow up to 24 months in the FRAAT birth cohort study

Th2 Cytokines and Atopic Dermatitis

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