Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment

Ribbens, Clio; Porras, Marlon; Franchimont, Nathalie; Kaiser, Marie‐Joëlle; Jaspar, Jean-Marie; Damas, Pierre; Houssiau, Frédéric; Malaise, Michel

doi:10.1136/ard.61.2.161

Cited by 203 publications

(128 citation statements)

References 27 publications

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“…1C, rightmost lane). The enzymes(s) responsible for endogenous IgG cleavage in the protease-rich SF and breast tumor environments (32)(33)(34) were not identified in the present investigation. Also, the rates at which IgG cleavage products are generated or accumulate in vivo were not specifically investigated here, although such determinations are of obvious interest for future study.…”

Section: Acontrasting

confidence: 41%

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

Brezski¹,

Vafa²,

Petrone³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

134

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The successful elimination of pathogenic cells and microorganisms by the humoral immune system relies on effective interactions between host immunoglobulins and Fc␥ receptors on effector cells, in addition to the complement system. Essential Ig motifs that direct those interactions reside within the conserved IgG lower hinge/CH2 interface. We noted that a group of tumor-related and microbial proteases cleaved human IgG1s in that region, and the ''nick'' of just one of the heavy chains profoundly inhibited IgG1 effector functions. We focused on IgG1 monoclonal antibodies (mAbs) since IgG1 is the most abundant human subclass and demonstrates robust Fc-mediated effector functions. The loss of Fc-mediated cell killing activities was correlated with diminished binding to the Fc␥ family of receptors, but a similar decrease in affinity was not observed toward the FcRn receptor that maintains IgG in circulation. Endogenous human IgG cleavage products of comparable size to mAbs with the single cleavage were detected by Western blot analysis in synovial fluid from patients with rheumatoid arthritis and in breast carcinoma extracts. Their detection is problematic under physiological conditions, since there is no loss of structure, and antigen-binding capability is unaffected. These findings suggest that within the hostile proteolytic microenvironments associated with many diseases, key effector functions of host IgGs, or therapeutic Abs, may be compromised.antibody-dependent cellular cytotoxicity ͉ complement-dependent cytotoxicity ͉ Fc gamma Receptors ͉ matrix metalloproteinases ͉ monoclonal antibodies

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Section: Acontrasting

confidence: 41%

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

Brezski¹,

Vafa²,

Petrone³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

134

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“…19,20 A possible correlation between steroid therapy and MMP-3 levels was examined in patients in the present study. All patients with active disease and 4 of 14 patients in remission received corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

Matrix Metalloproteinases as Novel Disease Markers in Takayasu Arteritis

et al. 2003

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Background-Takayasu arteritis (TA) is a chronic vasculitis that primarily affects large elastic arteries. Monitoring of disease activity is crucial because the disease tends to progress despite treatment with glucocorticoid and/or immunosuppressive agents. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) have generally been used as disease activity markers, but these are nonspecific inflammatory markers and lack the sensitivity and specificity to accurately monitor the disease status. Given the histological findings characterized by destruction of elastic fibers, we hypothesized that matrix metalloproteinases (MMPs) could be useful as markers of disease activity in TA. Methods and Results-A consecutive series of 25 patients with TA were enrolled in this study. According to the National Institutes of Health criteria of disease activity, 11 were in an active phase and the remaining 14 were in remission. Circulating levels of MMP-2, MMP-3, and MMP-9 were determined by ELISA in all patients with TA and controls. MMP-2 levels were higher in patients with TA than in controls, but no correlation was found between serum MMP-2 and disease activity score. In contrast, MMP-3 and MMP-9 levels in patients with active disease were higher than in patients in remission and controls, and a positive correlation was demonstrated between circulating levels of MMP-3 or MMP-9 and disease activity score. The high levels of MMP-3 and MMP-9 improved when patients underwent remission. Conclusions-The present results indicate that MMP-2 can be helpful in diagnosing TA and that MMP-3 and MMP-9 can be used as activity markers for TA.

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“…It can degrade various fibronectins and collagens, which are regarded as proteins found in bone and cartilage, such as collagen type IV, VI, and VII (Dhir et al, 2013). MMP-3 is implicated in the degradation of the ECM and tissue remodeling in normal biological processes, including embryonic development and cell reproduction as well as in pathological processes such as tumor metastasis and arthritis (Ribbens et al, 2002;Arends et al, 2011). In addition, MMP-3 is expressed in the serum and joint fluid of patients with AS and its level is closely related to the disease activity (Yang et al, 2004a).…”

Section: Discussionmentioning

confidence: 99%

Serum matrix metalloproteinases-3 levels in patients with ankylosing spondylitis

Jw¹,

Kf²,

Js³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Cumulated evidence indicates that matrix metalloproteinase-3 (MMP-3) is significantly involved in cancer progression. Recent studies yielded conflicting results regarding the association between serum MMP-3 and ankylosing spondylitis (AS). To clarify this correlation, we performed a meta-analysis. Potential relevant studies were identified by searching the following databases: PubMed, Embase, CINAHL, Science Citation Index database, the Cochrane Library, Current Contents Index, Chinese Biomedical, the Chinese Journal Full-Text, and the Weipu Journal. Data from eligible studies were extracted and included into the meta-analysis using a random-effect model. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were used to assess the association between serum MMP-3 levels and AS. Thirteen case-control studies, including 707 AS cases and 442 healthy controls, were selected for the meta-analysis. The results indicate a significantly higher serum MMP-3 level in patients with AS than that in the controls (cases vs controls: SMD = 1.31, 95%CI = 0.84-1.78, P < 0.001). Ethnicity-subgroup analysis indicated a higher MMP-3 level in Asian and Caucasian patients with AS (all P < 0.05). This meta-analysis indicates that increased serum MMP-3

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Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment

Cited by 203 publications

References 27 publications

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

Matrix Metalloproteinases as Novel Disease Markers in Takayasu Arteritis

Serum matrix metalloproteinases-3 levels in patients with ankylosing spondylitis

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