Increased Mean Platelet Volume in Patients with Bell’s Palsy

Özler, Gül Soylu; Okuyucu, Şemsettin

doi:10.5152/iao.2014.250

Cited by 3 publications

(6 citation statements)

References 23 publications

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“…In another study, MPV was found to be high in patients with BP. As a result of that study, the authors concluded that higher MPV values would be a predictor marker for the severity and prognosis of BP [18]. In our study, we did not find higher MPV and PLR values in BP patients than in those controls.…”

contrasting

confidence: 67%

Status of Lactate Dehydrogenase, Neutrophil-lymphocyte Ratio, Mean Platelet Volume, and Platelet-lymphocyte Ratio in Bell’s Palsy

Baklacı

Güler

Kuzucu

et al. 2020

Cureus

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contrasting

confidence: 67%

Status of Lactate Dehydrogenase, Neutrophil-lymphocyte Ratio, Mean Platelet Volume, and Platelet-lymphocyte Ratio in Bell’s Palsy

Baklacı

Güler

Kuzucu

et al. 2020

Cureus

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“…Additionally, they had showed that there was positive correlation between PDW and MPV values with grade of facial paralysis. However, they had reported that there was no correlation between MPV and PDW values and prognosis of facial paralysis [18]. In contrast, Kum et al [4] had reported no correlation with between the MPV value and grade of facial paralysis.…”

Section: Discussionmentioning

confidence: 98%

“…Platelets with a large volume have been showed to be metabolically and enzymatically more active and more tendencies to aggregation compared with the small ones [15][16][17]. Özler et al [18] had showed that the MPV and the PDW values in patients with Bell palsy were higher. Additionally, they had showed that there was positive correlation between PDW and MPV values with grade of facial paralysis.…”

Section: Discussionmentioning

confidence: 99%

The role of inflammation markers in predicting the prognosis of Bell's palsy

Ulusoy

Bozdemir

Kale

et al. 2019

The European Research Journal

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Objectives:This study aimed to investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) and Bell's palsy in addition to the usability of these markers to predict prognosis. Methods: In this prospective study, the patient group included 24 patients that were diagnosed with Bell's palsy and 29 healthy volunteers that had similar characteristics to them regarding age and gender with patient group as the control group. The temporal gadolinium-enhanced magnetic resonance imaging (TGd-MRI) was performed to all patients. The complete blood count was also obtained from both the patient and the control groups, and these two groups were compared for NLR and PLR, mean platelet volume (MPV), platelet distribution width (PDW), and platelet count. The relationship between these markers and Bell's paralysis prognosis was also investigated. Results: The patient and control groups were similar in age and gender (p > 0.05). NLR was significantly higher in the patient group compared with the control group (p = 0.016). There was no correlation between the NLR value and the prognosis of Bell's Palsy. The PDW and white blood cell count (WBC) were significantly higher in the patient group than the control group (p = 0.023 and p = 0.012, respectively). A comparison of the recovered and unrecovered patients revealed that the PDW value was significantly higher and the platelet count was lower in the recovered patients than the unrecovered patients (p = 0.009 and p = 0.003 respectively). The MPV value was higher in the recovered patients, though not statistically significant (p = 0.063). Based on the cut-off values determined in the receiver operator characteristic (ROC) curve analysis, a comparison of the recovered and unrecovered patients reveals that the likelihood of not healing was significantly higher in those that had normal PDW values (p = 0.036). Conclusion: These results might support the theory of inflammation in patients with Bell's palsy.

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“…It is widely known that NLR levels are highly correlated with BP prognosis [ 32 , 38 ]; certain studies have reported a higher NLR in BP patients experiencing poor outcomes [ 38 ], a positive correlation between NLR and disease severity [ 14 , 33 , 36 , 56 ], and longer recovery times in patients with a higher NLR [ 25 ]. Additionally, facial nerve contrast enhancement was confirmed by MRI in patients with a high NLR [ 36 ].…”

Section: Prognostic Biomarkers In Apfpmentioning

confidence: 99%

“…Considering the above-mentioned etiologic factors of APFP development, a laboratory test that evaluates prognosis is considered desirable. Numerous studies have investigated hematologic markers based on inflammatory mediators, vascular failure, oxidative stress, and immunological responses [ 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Biomarkers as Prognostic Factors in Acute Peripheral Facial Palsy

Kim¹,

Yeo²,

Byun³

2021

IJMS

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Acute peripheral facial palsy (APFP), including Bell’s palsy and Ramsay Hunt syndrome, is a disease that affects daily life through facial motor dysfunction, causing psychological problems. Various tests to evaluate prognosis have been studied; however, there are no validated predictive biomarkers to guide clinical decision making. Therefore, specific biomarkers that respond to treatment are required to understand prognostic outcomes. In this review, we discuss existing literature regarding the role of APFP biomarkers in prognosis and recovery. We searched the PubMed, EMBASE, and Cochrane Library databases for relevant papers. Our screening identified relevant studies and biomarkers correlating with the identification of predictive biomarkers. Only studies published between January 2000 and October 2021 were included. Our search identified 5835 abstracts, of which 35 were selected. All biomarker samples were obtained from blood and were used in the evaluation of disease severity and prognosis associated with recovery. These biomarkers have been effective prognostic or predictive factors under various conditions. Finally, we classified them into five categories. There is no consensus in the literature on the correlation between outcomes and prognostic factors for APFP. Furthermore, the correlation between hematologic laboratory values and APFP prognosis remains unclear. However, it is important to identify new methods for improving the accuracy of facial paralysis prognosis prediction. Therefore, we systematically evaluated prognostic and potentially predictive APFP biomarkers. Unfortunately, a predictive biomarker validating APFP prognosis remains unknown. More prospective studies are required to reveal and identify promising biomarkers providing accurate prognosis.

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Increased Mean Platelet Volume in Patients with Bell’s Palsy

Cited by 3 publications

References 23 publications

Status of Lactate Dehydrogenase, Neutrophil-lymphocyte Ratio, Mean Platelet Volume, and Platelet-lymphocyte Ratio in Bell’s Palsy

Status of Lactate Dehydrogenase, Neutrophil-lymphocyte Ratio, Mean Platelet Volume, and Platelet-lymphocyte Ratio in Bell’s Palsy

The role of inflammation markers in predicting the prognosis of Bell's palsy

Role of Biomarkers as Prognostic Factors in Acute Peripheral Facial Palsy

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