Increased migraine risk in osteoporosis patients: a nationwide population-based study

Wu, Chieh‐Hsin; Zhang, Zi-Hao; Wu, Ming‐Kung; Wang, Chiu-Huan; Lu, Ying‐Yi; Lin, Chih-Lung

doi:10.1186/s40064-016-3090-8

Cited by 8 publications

(8 citation statements)

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“…Therefore, no available data regarding direct measurements of stroke severity to estimate the association with osteoporosis was also mentioned 29. However, structured reviews have demonstrated high reliability and high validity in previous studies of administrative data 16–19 30. Notably, the validity of our results is increased by the structured methods used to collect data contained in the Taiwan NHIRD.…”

Section: Discussionmentioning

confidence: 93%

Stroke and osteoporosis: a Taiwan cohort study

Zhang

et al. 2020

Postgraduate Medical Journal

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BackgroundOsteoporosis and stroke are major health problems that have potentially overlapping pathophysiological mechanisms. The aim of this study was to estimate osteoporosis risk in Taiwan patientswho had a stroke.MethodThis study retrieved data contained in the Taiwan National Health Insurance Research Database for a population-based sample of consecutive patients either hospitalised for stroke or treated for stroke on an outpatient basis. A total of 7550 newly diagnosed patientswho had a stroke were enrolled during 1996–2010. Osteoporosis risk in these patients was then compared with a matched group of patients who had not had a stroke randomly selected from the database at a ratio of 1:4 (n=30 200). The relationship between stroke history and osteoporosis risk was estimated with Cox proportional hazard regression models.ResultsDuring the follow-up period, osteoporosis developed in 1537 patients who had a stroke and in 5830 patients who had not had a stroke. The incidence of osteoporosis for cohorts with and without stroke was 32.97 and 14.28 per 1000 person-years, respectively. After controlling for covariates, the overall risk of osteoporosis was 1.82-fold higher in the stroke group than in the non-stroke group. The relative osteoporosis risk contributed by stroke had apparently greater impact among male gender and younger age groups.ConclusionHistory of stroke is a risk factor for osteoporosis in Taiwan. Much attention to stroke-targeted treatment modalities might minimise adverse outcomes of osteoporosis.

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Section: Discussionmentioning

confidence: 93%

Stroke and osteoporosis: a Taiwan cohort study

Zhang

et al. 2020

Postgraduate Medical Journal

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“…Nevertheless, the NHIRD has been rigorously examined and extensively used in many studies in recent years. 63–65 Third, despite the relatively low healthcare costs in Taiwan, some patients attempt to eliminate AD and keloids through folk remedies or through private treatment by local pharmacists rather than by medical professionals. Moreover, the NHIRD does not record all information regarding risk factors such as body mass index, blood groups, smoking, alcohol consumption and operation sites, which potentially compromises our results.…”

Section: Discussionmentioning

confidence: 99%

Keloid risk in patients with atopic dermatitis: a nationwide retrospective cohort study in Taiwan

et al. 2018

BMJ Open

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ObjectiveThe pathogenesis of keloid is largely unknown. Because keloid and atopic dermatitis have overlapping pathophysiological mechanisms, we aimed to evaluate keloid risk in patients with atopic dermatitis.Study designPopulation-based retrospective cohort study.SettingThe Taiwan National Health Insurance Research Database was used to analyse data for people who had been diagnosed with atopic dermatitis.ParticipantsWe identified 8371 patients with newly diagnosed atopic dermatitis during 1996–2010. An additional 33 484 controls without atopic dermatitis were randomly identified and frequency matched at a one-to-four ratio.Primary and secondary outcome measureThe association between atopic dermatitis and keloid risk was estimated using Cox proportional hazard regression models.ResultsAfter adjustment for covariates, the atopic dermatitis patients have a 3.19-fold greater risk of developing keloid compared with the non-atopic dermatitis group (3.19vs1.07 per 1000 person-years, respectively). During the study period, 163 patients with atopic dermatitis and 532 patients without atopic dermatitis developed keloid. Notably, keloid risk increased with severity of atopic dermatitis, particularly in patients with moderate to severe atopic dermatitis.ConclusionsOur results indicate that patients with atopic dermatitis had a higher than normal risk of developing keloid and suggest that atopic dermatitis may be an independent risk factor for keloid.

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“…We assumed that inflammation and magnesium both played critical roles in the interplay between osteoporosis and migraine. Combining these results, it can be supposed that people with osteoporosis tend to have trigeminal neuralgia [ 24 ]. Secondly, the correlation of blood pressure regulation and calcium metabolism is a major link between hypertension and BMD.…”

Section: Discussionmentioning

confidence: 99%

The Risk of Trigeminal Neuralgia Following Osteoporosis

Wang

et al. 2022

Medicina

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Background and objectives: Managing people with trigeminal neuralgia (TN) and osteoporosis is challenging due to their debilitating conditions. Currently, the exact association between TN and osteoporosis in patients remains unknown, although there is potential overlapping of pathophysiological mechanisms. In response, we calculated TN risk in patients who have osteoporosis. Materials and Methods: 45,393 patients aged over 50 years diagnosed with osteoporosis were matched with 45,393 non-osteoporosis patients aged over 50 years (1:1 ratio) who were used as the control group, using data from 1996 to 2010 from Taiwan’s National Health Insurance Research Database. The cumulative incidences of subsequent TN and the hazard ratio were estimated using Cox proportional hazards modeling and the Kaplan–Meier method, respectively. Results: Among the total sample, 333 patients were diagnosed with TN during the follow-up period: 205 in the osteoporosis cohort and 128 in the control cohort. Through covariate adjustment, the overall TN incidence showed a 1.80-fold increase in the osteoporosis cohort in comparison with the control cohort (0.60 vs. 0.18 per 1000 person-years, respectively). The High Charlson Comorbidity Index, hypertension, and migraines were risk factors of TN. Conclusions: Osteoporosis patients had a higher TN risk than that of the control cohort. Therefore, early recognition of pain and symptoms in osteoporotic people may help to identify possible TN patients who need prompt therapy.

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Increased migraine risk in osteoporosis patients: a nationwide population-based study

Cited by 8 publications

References 50 publications

Stroke and osteoporosis: a Taiwan cohort study

Stroke and osteoporosis: a Taiwan cohort study

Keloid risk in patients with atopic dermatitis: a nationwide retrospective cohort study in Taiwan

The Risk of Trigeminal Neuralgia Following Osteoporosis

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