Increased Monozygotic Twinning Rate After Ovulation Induction

Derom, Cathérine; Derom, R.; Vlietinck, Robert; Berghe, H.Vanden; Thiéry, Michel

doi:10.1016/s0140-6736(87)92688-2

Cited by 307 publications

(158 citation statements)

References 6 publications

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“…A first set of twins was drawn from the East Flanders Prospective Twin Study (n = 31 pairs), in which zygosity was determined at birth, according to procedures outlined in Derom et al 12 A second set of twins was identified by searching the municipal and parish registers in several Flemish towns and the lists of students in the schools and the University of Leuven (n = 60 pairs). In the latter twin pairs, zygosity was determined according to procedures outlined in Fagard et al 13 Twin members were assigned number 1 or 2 according to the alphabetical order of their first names.…”

Section: Study Populationmentioning

confidence: 99%

The contribution of genes, environment and of body mass to blood pressure variance in young adult males

1999

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Objective: (1) To determine by means of multivariate genetic modelling whether the covariation of blood pressure (BP) and body mass index (BMI) is compatible with a direct effect of BMI on BP, or rather with pleiotropy or environmental association, and (2) to quantify the contribution of such an effect and of heritability and environmental factors to BP variance. Design and methods: Fifty monozygous and 41 dizygous male twin pairs (ages: 17-38 years) were studied. BMI was calculated as weight/height 2 . Blood pressure was the mean of three conventional measurements in the supine position. Estimates for the path coefficients of the three hypothesised models were obtained using Maximum Likelihood Estimation and were used to calculate the predicted covariance matrices for these models. A 2 goodness-of-fit index of P Ͼ 0.05 indicated an adequate fit. Likelihood ratio 2 statistics and the Akaike

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Section: Study Populationmentioning

confidence: 99%

The contribution of genes, environment and of body mass to blood pressure variance in young adult males

1999

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“…derom et al 1 reported an increased incidence of mZT in patients after the induction of ovulation with gonadotrophins or clomifen citrate. They believed that medication can alter the structure of the Zp, making the embryo more vulnerable to icm splitting.…”

Section: Ovulation Inductionmentioning

confidence: 99%

“…monozygotic twinning (mZT) is a relatively rare phenomenon, with an incidence of about 1% of natural conceptions. in assisted conceptions, the risk of monozygotic twinning has been estimated to be about twice as high 1 . multiple births are generally associated with many maternal and fetal complications, which are more severe in mZT that share a single placenta.…”

Section: Introductionmentioning

confidence: 99%

High incidence of monozygotic twinning in infertility treatment

Sobek¹,

Procházka²,

Klásková³

et al. 2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Background. Monozygotic twinning is associated with increased perinatal morbidity and mortality. There is evidence that the number of monozygotic twins increases after assisted reproductive techniques. Methods. We searched PUBMED, MEDLINE, and Scopus from 1987 to 2015 for studies analyzing the incidence and possible etiology of monozygotic twinning in infertility patients and critically reviewed the current state of knowledge. Results and Conclusions. Monozygotic twinning is a rare in natural conception but occurs around twice the normal rate after assisted reproduction. Factors associated with this phenomenon remain speculative, though there is some evidence that micromanipulation techniques, prolonged culture, and genetics are involved. In view of the possible complications, adequate pre-conception counselling is advocated.

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“…Unlike dizygotic twinning, the prevalence of MZ twinning has been remarkably constant worldwide (Dunn and Macfarlane 1996;Guttmacher 1953;Hur et al 1995;MacGillivray 1986;Parazzini et al 1991). However, in the late 1980s, Derom and colleagues reported a 2-fold increase in the MZ twin birth rate among women from their population-based study in East Flanders, Belgium, who had conceived after therapy with an ovulation-inducing medication, compared with the rate among women who conceived naturally (Derom et al 1987). This was the first report that an extrinsic factor might affect zygotic division.…”

Section: Assisted Reproductive Technologiesmentioning

confidence: 99%

Off to a good start: the influence of pre- and periconceptional exposures, parental fertility, and nutrition on children's health.

Chapin

Robbins

Schieve

et al. 2004

Environ Health Perspect

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The scientific community is developing a compelling body of evidence that shows the importance of the in utero environment (including chemical and hormonal levels) to the ultimate health of the child and even of the aging adult. This article summarizes the evidence that shows this impact begins with conception. Only a full life-cycle evaluation will help us understand these impacts, and only such an understanding will produce logically prioritized mitigation strategies to address the greatest threats first. Clearly, the time for analysis begins when the next generation is but a twinkle in the eye.

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Increased Monozygotic Twinning Rate After Ovulation Induction

Cited by 307 publications

References 6 publications

The contribution of genes, environment and of body mass to blood pressure variance in young adult males

The contribution of genes, environment and of body mass to blood pressure variance in young adult males

High incidence of monozygotic twinning in infertility treatment

Off to a good start: the influence of pre- and periconceptional exposures, parental fertility, and nutrition on children's health.

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