Increased mortality in COPD among construction workers exposed to inorganic dust

Bergdahl, Ingvar A.; Torén, Kjell; Eriksson, Kristina; Hedlund, Ulf; Nilsson, Tohr; Flodin, R; Järvholm, Bengt

doi:10.1183/09031936.04.00034304

Cited by 178 publications

(132 citation statements)

References 35 publications

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“…In miners and construction workers, dust exposure tends to increase the incidence for chronic bronchitis Bergdahl et al 2004) as well as for asthma Karjalainen et al 2002a). An interesting question is why some individuals show higher risks of developing asthma and yet others develop chronic bronchitis after exposure to irritants.…”

Section: Synthesis With Previous Knowledgementioning

confidence: 99%

“…Our first study was performed on cases diagnosed 1950 -1990 in two communities with dominating wood industry (Flodin et al 1996), the second study encompassed cases of asthma diagnosed 1960 -1997 in a metal industry dominated community ( Flodin et al 2004). Those two studies found an significant excess risk for asthma in subjects having worked for at least tree years in non sensitising air polluted workshops.…”

Section: Introductionmentioning

confidence: 99%

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Non-sensitising air pollution at workplaces and adult-onset asthma in the beginning of this millennium

Graff¹,

Fredrikson²,

Jonsson³

et al. 2011

Int Arch Occup Environ Health

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Non-sensitising air pollution at workplaces and adult onset asthma -2- AbstractPurpose This case-control study was undertaken to elucidate the controversy concerning whether low level, long-term exposure to non-sensitising air pollution at workplaces may cause asthma.Methods A case-control study of 192 adult onset asthma cases aged 20 -65 years and 323 controls was conducted in the southeast of Sweden. Cases were identified from computerised registers from the region, diagnosed 2000-2004 and diagnoses were confirmed via medical files. Referents were randomised from the population register of the region. Exposure was monitored by a 16-page questionnaire. Special attention was devoted to identifying and in the final analyses excluding subjects exposed to sensitising agents.Results Three years or more of occupational exposure to air pollution from dust, smoke, fumes or vapours before the year of diagnosis by analyses adjusting for age yielded an increased risk for asthma (OR =2.3, 95 % CI 1.2-4.2) in males, while in females no risk was seen. In a multiple logistic regression analysis in males without allergy in childhood, a significant risk was seen (OR=2.8, 95 % CI 1.07 -7.4), when subjects exposed to identified allergens were excluded. In females no excess risk was observed from occupational air pollution. ConclusionThe results of this study support an association between occupational exposure to low level non-sensitising air pollution and adult onset asthma in males.Non-sensitising air pollution at workplaces and adult onset asthma -3-

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Section: Synthesis With Previous Knowledgementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Non-sensitising air pollution at workplaces and adult-onset asthma in the beginning of this millennium

Graff¹,

Fredrikson²,

Jonsson³

et al. 2011

Int Arch Occup Environ Health

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“…Además, los menores valores de flujo espiratorio pico se asociaban a la condición socioeconómica (45), a un mayor tiempo de residencia en el barrio y a la exposición ocupacional previa (46)(47)(48).…”

Section: Discussionunclassified

Impacto de un sitio de disposición final de residuos sólidos en la salud respiratoria de los adultos mayores

2011

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Introducción. El objetivo de este estudio fue evaluar el impacto de un sitio de disposición final de residuos sólidos sobre la salud respiratoria de adultos mayores de 50 años, residentes en su área de influencia. Materiales y métodos. Se llevó a cabo un estudio de cohortes que incluyó un grupo de 313 adultos mayores de 50 años expuestos al Botadero de Navarro y otro de 359 no expuestos, seguidos durante seis meses, para comparar la incidencia mensual de síntomas respiratorios y alteraciones en el flujo espiratorio pico. Resultados. Después de ajustar por edad, sexo, escolaridad, humedad, afiliación a salud, enfermedades concomitantes, tabaquismo y exposición ocupacional previa, la exposición al Botadero de Navarro se asoció con la presencia de uno o más síntomas respiratorios (OR=1,25; IC 95% : 1,01-1,56), síntomas respiratorios moderados (OR=1,28; IC 95% : 0,98-1,66), pero no se encontró asociación con síntomas respiratorios graves (OR= 1,16; IC 95% : 0,89-1,50). Se evidenció una mayor recurrencia de síntomas en los adultos de la zona expuesta (coeficiente de correlación=0,29, IC 95% : 0,23-0,33, p=0,000). En los adultos expuestos al Botadero de Navarro, se encontró en la función pulmonar una reducción significativa del flujo espiratorio pico (-15,19 L/minuto; IC 95% : -30,16-0,22). Conclusión. Este estudio muestra que, independientemente de los potenciales factores de confusión, la salud respiratoria de los adultos mayores de 50 años expuestos al Botadero de Navarro está afectada con una mayor presencia y cronicidad de síntomas respiratorios moderados y una disminución de la función pulmonar.Palabras clave: eliminación de residuos sólidos, contaminación ambiental, botaderos a cielo abierto, sistema respiratorio, anciano. Impact of a waste disposal site on adult respiratory healthIntroduction. This study evaluated the impact of the presence of a dump on respiratory health in adults older than 50 years of age, living in its area of influence. Materials and methods. A cohort study was conducted with 313 adults older than 50 years of age living near the Navarro Dump (Cali, Colombia) and compared with 359 adults in an unexposed area. Each was examined monthly during a 6 month period to compare the incidence of respiratory symptoms and alterations in peak expiratory flow. Results. Exposure to the Navarro Dump was associated with occurrence of respiratory symptoms (odds ratio=1.25, 95% C.I. 1.01-1.56), in particular with mild respiratory symptoms (odds ratio=1.28, 95% C.I. 0.98-1.66). This result was obtained after adjusting for age, sex, education level, humidity, health insurance, comorbidity, smoking and previous occupational exposure. A higher recurrence of symptoms was found in adults in the area of exposure (correlation coefficient=0.29, 95% C.I. 0.23-0.33, p<0.001) and a significant reduction in the lung function defined by peak expiratory flow; the average decrease was15.2 L/min (95% C.I. -30.2 to +0.22). Conclusion. Independent of potential confounding factors, the respiratory health of adults exposed to th...

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“…Industryand population-based epidemiological studies have reported increased risk of COPD due to occupational exposures or due to employment in certain industries or job categories. Occupational groups reported to have increased risk of COPD include coal miners, hard rock miners, tunnel workers, concretemanufacturing workers, construction workers, agricultural workers, and some manufacturing workers [2,3,[6][7][8][9]. COPD etiology is multi-factorial in nature and is strongly associated with non-occupational factors such as tobacco smoking.…”

Section: Introductionmentioning

confidence: 99%

“…Although cigarette smoking is the most important risk factor worldwide for COPD, occupational exposures to mineral and organic dusts, irritant gases and fumes, and to other industrially produced or used agents have been established as risk factors for COPD [2][3][4][5][6][7][8][9][10][11][12][13][14]. Industryand population-based epidemiological studies have reported increased risk of COPD due to occupational exposures or due to employment in certain industries or job categories.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Lifetime Occupational Exposure in an Epidemiologic Study of COPD

Graziani¹,

Doney²,

Hnizdo³

et al. 2012

TOEPIJ

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Ascertainment of lifetime occupational exposures in an epidemiological study of chronic obstructive pulmonary disease (COPD) is important in order to investigate its effect on the disease and develop prevention strategies. The aim of our paper is to describe and evaluate a methodology used to assign lifetime occupational exposure to participants in a case-control study of COPD where lifetime occupational history was ascertained through telephone questionnaire interviews.The methodology involved assigning to each individual a qualitative index of potential exposure to eight occupational hazards, summarized individually overall the job categories reported by the individual, and an overall qualitative index of lifetime exposure to all eight hazards. The eight occupational hazards scored were mineral dusts, metal dusts/fumes, organic dusts, irritant gases/vapors, sensitizers, organic solvents, diesel exhaust, and environmental tobacco smoke (ETS). Two industrial hygienists independently assigned the above indices based on: their expert opinion, a priori knowledge based on literature review, and study participants' responses to interviewer questions regarding types and duration of exposure. To evaluate agreement of the assigned scores, we used the Kappa statistic to test the agreement between the two scorers on each of the indices. The Kappa statistic generally indicated good agreement between the industrial hygienists' scores but varied by exposure from 0.42 to 0.86. Although the exposure scoring is somewhat subjective, it is based on experience of experts and review of the literature. This method, with subject interviews providing qualitative lifetime exposure data when air monitoring has not been conducted, is useful for reconstructing lifetime exposures.

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Increased mortality in COPD among construction workers exposed to inorganic dust

Cited by 178 publications

References 35 publications

Non-sensitising air pollution at workplaces and adult-onset asthma in the beginning of this millennium

Non-sensitising air pollution at workplaces and adult-onset asthma in the beginning of this millennium

Impacto de un sitio de disposición final de residuos sólidos en la salud respiratoria de los adultos mayores

Assessment of Lifetime Occupational Exposure in an Epidemiologic Study of COPD

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